BRPI0907974A2 - Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças - Google Patents

Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças

Info

Publication number: BRPI0907974A2
Authority: BR; Brazil
Prior art keywords: compound; treating; pharmaceutical composition; preventing disease; disease
Prior art date: 2008-03-07

Application number

BRPI0907974-2A

Other languages

English (en)

Inventor

Angelo Guglielmotti

Guido Furlotti

Giorgina Mangano

Nicola Cazzolla

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-07

Filing date

2009-03-05

Publication date

2015-08-04

2009-03-05 Application filed by Acraf filed Critical Acraf

2015-08-04 Publication of BRPI0907974A2 publication Critical patent/BRPI0907974A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Surgery (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)

BRPI0907974-2A 2008-03-07 2009-03-05 Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças BRPI0907974A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08425140		2008-03-07
PCT/EP2009/052588 WO2009109616A2 (en)	2008-03-07	2009-03-05	Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40

Publications (1)

Publication Number	Publication Date
BRPI0907974A2 true BRPI0907974A2 (pt)	2015-08-04

Family

ID=39672136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0907974-2A BRPI0907974A2 (pt)	2008-03-07	2009-03-05	Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças

Country Status (25)

Country	Link
US (2)	US8461194B2 (pt)
EP (1)	EP2262778B8 (pt)
JP (1)	JP5509100B2 (pt)
KR (1)	KR101640844B1 (pt)
CN (1)	CN101965337B (pt)
AR (1)	AR070812A1 (pt)
AU (1)	AU2009221087B2 (pt)
BR (1)	BRPI0907974A2 (pt)
CA (1)	CA2714436C (pt)
CY (1)	CY1122349T1 (pt)
DK (1)	DK2262778T5 (pt)
EA (1)	EA018976B1 (pt)
ES (1)	ES2753149T3 (pt)
GE (1)	GEP20135927B (pt)
HR (1)	HRP20191953T8 (pt)
HU (1)	HUE047318T2 (pt)
IL (1)	IL207277A (pt)
LT (1)	LT2262778T (pt)
MX (1)	MX2010009625A (pt)
PL (1)	PL2262778T3 (pt)
PT (1)	PT2262778T (pt)
SG (1)	SG188178A1 (pt)
SI (1)	SI2262778T1 (pt)
UA (1)	UA103609C2 (pt)
WO (1)	WO2009109616A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8461194B2 (en) *	2008-03-07	2013-06-11	Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
BRPI0908883A2 (pt)	2008-03-07	2015-09-15	Acraf	composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
JP5509099B2 (ja) *	2008-03-07	2014-06-04	アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ	新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体並びにそのＭＣＰ−１、ＣＸ３ＣＲ１およびｐ４０の発現に基づく疾患の治療への使用
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
WO2012078633A2 (en)	2010-12-07	2012-06-14	Philadelphia Health And Education Corporation, D/B/A Drexel University College Of Medicene	Methods of inhibiting metastasis from cancer
EP2850062B1 (en)	2012-05-18	2017-07-19	Sanofi	Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
US9346762B2 (en)	2012-05-18	2016-05-24	Sanofi	Pyrazole derivatives and their use as LPAR5 antagonists
SG11201407775WA (en)	2012-05-25	2014-12-30	Berg Llc	Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
CA2874919A1 (en) *	2012-06-01	2013-12-05	Nogra Pharma Limited	Bicyclic heterocycles capable of modulating t-cell responses, and methods of using same
US9013997B2 (en)	2012-06-01	2015-04-21	Broadcom Corporation	System for performing distributed data cut-through
US10023864B2 (en)	2014-06-06	2018-07-17	Berg Llc	Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
EP3310353A4 (en) *	2015-06-16	2019-02-06	Translatum Medicus, Inc.	COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF EYE DISEASES
CA2999769A1 (en) *	2015-09-28	2017-04-06	Genentech, Inc.	Therapeutic compounds and methods of use thereof
WO2018204370A1 (en)	2017-05-02	2018-11-08	Drexel University	Cx3cr1 small molecule antagonists, and methods using same
EP3990433A4 (en) *	2019-06-25	2023-07-26	Translatum Medicus Inc.	METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1230441B (it)	1989-02-07	1991-10-23	Acraf	Eteri della serie dell'indazolo
IT1253703B (it)	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it)	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
EP1185528A4 (en)	1999-06-17	2003-03-26	Shionogi Biores Corp	INHIBITORS OF IL-12 PRODUCTION
EP1188438A1 (en)	2000-09-15	2002-03-20	Warner-Lambert Company	Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en)	2000-09-15	2002-04-24	Warner-Lambert Company	Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
CA2440744C (en)	2001-03-15	2009-12-08	Seikagaku Corporation	Il-12 expression controlling agent
JP2005519034A (ja)	2001-11-30	2005-06-30	シンタファーマシューティカルズコーポレーション	ピリミジン化合物
MXPA06003792A (es)	2003-10-07	2006-06-14	Astrazeneca Ab	Nuevas 4-amino-tiazolo[4,5-d]-pirimidinas 2-sustituidas, utiles como antagonistas del receptor de quimiocina, especialmente cx3cr1.
US20070043057A1 (en) *	2005-02-09	2007-02-22	Threshold Pharmaceuticals, Inc.	Lonidamine analogs
US20070015771A1 (en)	2004-07-29	2007-01-18	Threshold Pharmaceuticals, Inc.	Lonidamine analogs
US7514463B2 (en) *	2004-08-20	2009-04-07	University Of Kansas	Lonidamine analogues and their use in male contraception and cancer treatment
DE102004043005A1 (de) *	2004-09-02	2006-03-09	Biotronik Vi Patent Ag	Signalverarbeitungsvorrichtung für physiologische Signale
WO2006053227A2 (en)	2004-11-10	2006-05-18	Synta Pharmaceuticals Corp.	Il-12 modulatory compounds
JP2006137718A (ja) *	2004-11-12	2006-06-01	Astellas Pharma Inc	インドール若しくはインダゾール誘導体
AU2005310143A1 (en)	2004-11-19	2006-06-08	Synta Pharmaceuticals Corp.	Pyrimidine compounds and uses thereof
AR053347A1 (es)	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en)	2005-04-06	2010-05-25	Астразенека Аб	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
US7858645B2 (en) *	2006-11-01	2010-12-28	Hoffmann-La Roche Inc.	Indazole derivatives
CN101074208A (zh) *	2007-06-29	2007-11-21	方炳良	吲哚衍生物的制备方法
JP5509099B2 (ja) *	2008-03-07	2014-06-04	アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ	新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体並びにそのＭＣＰ−１、ＣＸ３ＣＲ１およびｐ４０の発現に基づく疾患の治療への使用
BRPI0908883A2 (pt) *	2008-03-07	2015-09-15	Acraf	composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
US8461194B2 (en) *	2008-03-07	2013-06-11	Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
CA2765700C (en) *	2009-06-16	2021-01-05	Opko Curna, Llc	Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
EP2462119B1 (en) *	2009-08-03	2014-06-11	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.	Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

2009
- 2009-03-05 US US12/865,792 patent/US8461194B2/en not_active Expired - Fee Related
- 2009-03-05 LT LT09718483T patent/LT2262778T/lt unknown
- 2009-03-05 JP JP2010549145A patent/JP5509100B2/ja active Active
- 2009-03-05 EP EP09718483.2A patent/EP2262778B8/en active Active
- 2009-03-05 ES ES09718483T patent/ES2753149T3/es active Active
- 2009-03-05 SG SG2013013131A patent/SG188178A1/en unknown
- 2009-03-05 CN CN2009801068437A patent/CN101965337B/zh not_active Expired - Fee Related
- 2009-03-05 MX MX2010009625A patent/MX2010009625A/es active IP Right Grant
- 2009-03-05 SI SI200932007T patent/SI2262778T1/sl unknown
- 2009-03-05 DK DK09718483.2T patent/DK2262778T5/da active
- 2009-03-05 AU AU2009221087A patent/AU2009221087B2/en not_active Ceased
- 2009-03-05 PL PL09718483T patent/PL2262778T3/pl unknown
- 2009-03-05 HU HUE09718483A patent/HUE047318T2/hu unknown
- 2009-03-05 GE GEAP200911964A patent/GEP20135927B/en unknown
- 2009-03-05 BR BRPI0907974-2A patent/BRPI0907974A2/pt not_active IP Right Cessation
- 2009-03-05 KR KR1020107019965A patent/KR101640844B1/ko active IP Right Grant
- 2009-03-05 WO PCT/EP2009/052588 patent/WO2009109616A2/en active Application Filing
- 2009-03-05 CA CA2714436A patent/CA2714436C/en not_active Expired - Fee Related
- 2009-03-05 EA EA201071039A patent/EA018976B1/ru not_active IP Right Cessation
- 2009-03-05 PT PT97184832T patent/PT2262778T/pt unknown
- 2009-03-06 AR ARP090100802A patent/AR070812A1/es unknown
- 2009-05-03 UA UAA201009901A patent/UA103609C2/uk unknown
2010
- 2010-07-29 IL IL207277A patent/IL207277A/en not_active IP Right Cessation
2013
- 2013-05-21 US US13/898,950 patent/US9255073B2/en not_active Expired - Fee Related
2019
- 2019-10-28 HR HRP20191953TT patent/HRP20191953T8/hr unknown
- 2019-11-18 CY CY20191101210T patent/CY1122349T1/el unknown

Also Published As

Publication number	Publication date
KR20100133970A (ko)	2010-12-22
IL207277A0 (en)	2010-12-30
CA2714436A1 (en)	2009-09-11
PT2262778T (pt)	2019-11-19
WO2009109616A2 (en)	2009-09-11
WO2009109616A8 (en)	2010-08-12
CY1122349T1 (el)	2020-11-25
HRP20191953T1 (hr)	2020-01-24
MX2010009625A (es)	2010-09-28
IL207277A (en)	2015-03-31
US8461194B2 (en)	2013-06-11
CA2714436C (en)	2017-06-27
JP2011513366A (ja)	2011-04-28
CN101965337B (zh)	2013-11-06
US20110082141A1 (en)	2011-04-07
US9255073B2 (en)	2016-02-09
ES2753149T3 (es)	2020-04-07
EA018976B1 (ru)	2013-12-30
GEP20135927B (en)	2013-10-10
LT2262778T (lt)	2019-11-11
SI2262778T1 (sl)	2019-12-31
EP2262778B8 (en)	2020-01-01
DK2262778T5 (da)	2020-06-08
EA201071039A1 (ru)	2011-02-28
CN101965337A (zh)	2011-02-02
US20130267704A1 (en)	2013-10-10
HUE047318T2 (hu)	2020-04-28
AR070812A1 (es)	2010-05-05
AU2009221087B2 (en)	2013-12-05
EP2262778B1 (en)	2019-08-21
EP2262778A2 (en)	2010-12-22
WO2009109616A3 (en)	2009-12-10
UA103609C2 (en)	2013-11-11
PL2262778T3 (pl)	2020-02-28
KR101640844B1 (ko)	2016-07-19
HRP20191953T8 (hr)	2021-06-25
JP5509100B2 (ja)	2014-06-04
DK2262778T3 (da)	2019-11-18
AU2009221087A1 (en)	2009-09-11
SG188178A1 (en)	2013-03-28

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-01-02	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 10A ANUIDADE.
2019-02-12	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-04-24	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2504 DE 02-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0917458A2 (pt)	2015-12-01	composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto
BRPI0907976A2 (pt)	2015-08-04	Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
BRPI0818244A2 (pt)	2015-06-16	Composto, composição farmacêutica, uso de um composto, e, método para tratamento de um distúrbio ou doença
BRPI0907974A2 (pt)	2015-08-04	Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
BRPI0913585A2 (pt)	2015-10-27	composto, método para fabricar um composto, composição farmacêutica, uso de um composto, e, método para o tratamento ou prevenção de distúrbios
BRPI0912348A2 (pt)	2015-10-13	composto de 3-aminocarbazol, composição farmacêutica, método para preparar um composto de 3-aminocarbazol, uso de um composto de 3-aminocarbazol, e, método para tratar ou prevenir doenças
BRPI0922475A2 (pt)	2017-06-06	composto, composição farmacêutica , método para tratar câncer, e, uso de um composto.
BRPI0908883A2 (pt)	2015-09-15	composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
BRPI0917705A2 (pt)	2016-02-16	composto, pró-droga, composição farmacêutica, método para tratar ou prevenir uma doença ou condição, e, uso do composto
BRPI0819799A2 (pt)	2015-05-26	Composto, intermediário, uso de um composto, composição farmacêutica, e, método para prevenir, tratar ou melhorar uma doença
BRPI1013984A2 (pt)	2018-06-19	composto , composição farmacêutica, método para tratamento ou profilaxia de uma doença ou condição, e, uso de um composto.
BRPI1008383A2 (pt)	2016-02-23	composto, composição farmacêutica, método para prevenir, inibir ou tratar uma condição, e, uso de um composto
BRPI0911685A2 (pt)	2015-10-13	composto, método para o tratamento de uma doença, uso de um composto, composição farmacêutica, e, kit
BRPI0819755A2 (pt)	2018-07-17	composto, composição farmacêutica, processos para a preparação de um composto e de uma composição farmacêutica, uso de um composto, e, método para tratar ou reduzir o risco de uma doença ou uma condição inflamatória
BRPI0815591A2 (pt)	2015-03-03	Composto, composição farmacêutica, uso de um composto, e, método para tratar uma doença, condição ou distúrbio.
BR122020011920A2 (pt)	2020-08-25	composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e processos para a preparação de um composto, e para a fabricação de um composto
BRPI0917138A2 (pt)	2015-11-17	composto, métodos para tratar doenças alérgicas e outras condições inflamatórias, rinite alérgica, e para tratar ou prevenir doença, composição farmacêutica, uso de um composto, e, combinação.
BRPI0816881A2 (pt)	2015-03-17	Composto, composição farmacêutica, uso de um composto, e, métodos para tratar doenças ou distúrbios e para preparar um composto.
BR112014011671A2 (pt)	2017-05-30	composto, composição farmacêutica, método para o tratamento de uma doença ou condição, e, uso de um composto
BRPI0917013A2 (pt)	2016-02-16	métodos para tratar doenças alérgicas e outras condições inflamatórias, e para tratar ou prevenir doença, composto, composição farmacêutica, e, uso de um composto
BRPI0906786A2 (pt)	2015-07-14	Composto, processo para a preparação de um composto, uso de um composto, método para o tratamento de uma doença ou condição, composição farmacêutica, processo para a preparação de uma composição farmacêutica, produto, e, kit.
BRPI0909768A2 (pt)	2015-10-06	composto, composição farmacêutica, método para o tratamento ou prevenção de uma doença ou distúrbio mediados pela ativação de b3-adrenoceptor, e, uso de um composto""composto, composição farmacêutica, método para o tratamento ou orevenção de uma doença ou distúrbio mediados pela ativação de b3-adrenoceptor, e, uso de um composto
BRPI0821299A2 (pt)	2015-06-16	Composto, processo para preparar o mesmo, composição farmacêutica, processo para preparar a mesma, uso de um composto, e, método para tratar, ou reduzir o risco de, uma doença ou condição.
BRPI0718587A2 (pt)	2014-03-11	Uso de um composto, compostos, método de tratamento ou prevenção de doenças, processos para a preparação do composto e composição farmacêutica contendo o mesmo
BRPI0912539A2 (pt)	2015-10-13	composto, composição farmacêutica , método para tratar uma doença, e, uso do composto.