BRPI0923786C8 - compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostos - Google Patents
compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostosInfo
- Publication number
- BRPI0923786C8 BRPI0923786C8 BRPI0923786A BRPI0923786A BRPI0923786C8 BR PI0923786 C8 BRPI0923786 C8 BR PI0923786C8 BR PI0923786 A BRPI0923786 A BR PI0923786A BR PI0923786 A BRPI0923786 A BR PI0923786A BR PI0923786 C8 BRPI0923786 C8 BR PI0923786C8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- phenylbenzo
- dihydro
- pharmaceutical compositions
- isoquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos. a presente invenção refere-se a compostos 5,6-dihidro-6-fenilbenzo [f] isoquinolin-2-amina substituídos e aos métodos de sintetizar esses compostos. a presente invenção também se relaciona com composições farmacêuticas contendo compostos 5,6-dihidro-6-fenilbenzo [f] isoquinolin-2-amina substituídos e métodos de tratamento de distúrbios de proliferação celular, tais como câncer, pela administração desses compostos e composições farmacêuticas a indivíduos em necessidade do mesmo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14143908P | 2008-12-30 | 2008-12-30 | |
US61/141.439 | 2008-12-30 | ||
US26050509P | 2009-11-12 | 2009-11-12 | |
US61/260.505 | 2009-11-12 | ||
PCT/US2009/069813 WO2010078421A1 (en) | 2008-12-30 | 2009-12-30 | Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0923786A2 BRPI0923786A2 (pt) | 2016-07-26 |
BRPI0923786B1 BRPI0923786B1 (pt) | 2020-11-24 |
BRPI0923786C1 BRPI0923786C1 (pt) | 2021-05-11 |
BRPI0923786C8 true BRPI0923786C8 (pt) | 2021-05-25 |
Family
ID=41682678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0923786A BRPI0923786C8 (pt) | 2008-12-30 | 2009-12-30 | compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostos |
Country Status (14)
Country | Link |
---|---|
US (1) | US8357694B2 (pt) |
EP (1) | EP2379506B1 (pt) |
JP (1) | JP5739820B2 (pt) |
KR (1) | KR101714799B1 (pt) |
CN (1) | CN102325755B (pt) |
BR (1) | BRPI0923786C8 (pt) |
CA (1) | CA2748491C (pt) |
DK (1) | DK2379506T3 (pt) |
ES (1) | ES2554623T3 (pt) |
IL (1) | IL213787A (pt) |
MX (1) | MX2011006959A (pt) |
TW (1) | TWI461410B (pt) |
WO (1) | WO2010078421A1 (pt) |
ZA (1) | ZA201104706B (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
US8716297B2 (en) | 2011-07-15 | 2014-05-06 | Abbvie Inc. | Chemical entities to be used for Wee1 inhibition for the treatment of cancer |
GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
ME03300B (me) | 2012-06-13 | 2019-07-20 | Incyte Holdings Corp | Supsтituisana triciklična jedinjenja као inhibiтori fgfr |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
SG11201700703XA (en) | 2014-08-18 | 2017-03-30 | Eisai R&D Man Co Ltd | Salt of monocyclic pyridine derivative and crystal thereof |
EP3189036B1 (en) | 2014-09-05 | 2023-07-19 | ArQule, Inc. | Compositions and methods for treating proliferation disorders |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
JP2018537499A (ja) | 2015-12-17 | 2018-12-20 | アークル インコーポレイテッド | 置換5,6−ジヒドロ−6−フェニルベンゾ[f]イソキノリン−2−アミン化合物の固体形態 |
EP4015508A1 (en) * | 2015-12-17 | 2022-06-22 | ArQule, Inc. | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
SG11202007591RA (en) | 2018-03-28 | 2020-09-29 | Eisai R&D Man Co Ltd | Therapeutic agent for hepatocellular carcinoma |
US11466004B2 (en) | 2018-05-04 | 2022-10-11 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
EA202092649A1 (ru) | 2018-05-04 | 2021-06-21 | Инсайт Корпорейшн | Соли ингибитора fgfr |
CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
CA3114147A1 (en) | 2018-09-27 | 2020-04-02 | Betta Pharmaceuticals Co., Ltd | Fgfr4 inhibitor and use thereof |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
IL291901A (en) | 2019-10-14 | 2022-06-01 | Incyte Corp | Bicyclyl heterocycles as fgr suppressors |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
CN116601155A (zh) * | 2020-11-26 | 2023-08-15 | 成都赛璟生物医药科技有限公司 | 杂芳基并喹唑啉类化合物作为蛋白激酶抑制剂 |
AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
CN113354630B (zh) * | 2021-06-30 | 2022-11-01 | 江南大学 | 一种5,6-二氢苯并[h]喹唑啉类化合物及其应用 |
WO2023072913A1 (en) * | 2021-10-25 | 2023-05-04 | Twentyeight-Seven, Inc. | Benzo[h]quinazoline-4-amine derivatives for the treatment of cancer |
WO2023196629A1 (en) * | 2022-04-07 | 2023-10-12 | Redona Therapeutics, Inc. | Benzo[h]quinazoline-4-amine derivatives for the treatment of cancer |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2623846A1 (de) * | 1976-05-28 | 1977-12-15 | Hoechst Ag | 4-chinazolinyl-guanidine und verfahren zu ihrer herstellung |
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
IT1154024B (it) | 1982-09-22 | 1987-01-21 | Lepetit Spa | Derivati pridinici e procedimento per la loro produzione |
US4625026A (en) | 1982-12-30 | 1986-11-25 | Biomeasure, Inc. | 2-amino-4-oxo-tricyclicpyrimidines having antiviral activities against herpes simplex virus type II infections |
US4814335A (en) | 1982-12-30 | 1989-03-21 | Biomeasure, Incorporated | Antiviral compounds |
DD240010A1 (de) | 1985-03-22 | 1986-10-15 | Univ Berlin Humboldt | Verfahren zur herstellung von substituierten 2-imino-1h-pyridin-1-aminen |
SU1540240A1 (ru) | 1988-05-16 | 1995-09-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 5-ЗАМЕЩЕННЫЕ 1-АМИНО -8,9-ДИГИДРО -8,8-ДИМЕТИЛ-3, 6Н- ПИРАЗОЛО [3,4-B] ПИРАНО[[4′,3′-d]] ПИРИДИНА ИЛИ ИХ ГИДРОХЛОРИДЫ, ОБЛАДАЮЩИЕ ПРОТИВОСУДОРОЖНОЙ АКТИВНОСТЬЮ |
DD280109A1 (de) | 1989-02-22 | 1990-06-27 | Univ Berlin Humboldt | Verfahren zur herstellung substituierter 1.2.4-triazolo/1.5-a/-pyridine |
SU1626648A1 (ru) | 1989-07-20 | 1995-09-27 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 1-амино-8,9- дигидро-5,8,8- триметил-3,6н- пиразоло[3,4-b] тиопирано [4,3-d]пиридин или его гидрохлорид, обладающие противосудорожной активностью |
DE4117802A1 (de) | 1991-05-30 | 1992-12-03 | Berlin Chemie Ag | 2-aminopyridin-3-carbonitrile als selektive hemmstoffe des humanen cytomegalievirus |
AU7831694A (en) | 1993-09-24 | 1995-04-10 | Du Pont Merck Pharmaceutical Company, The | Improved methods for preparing bis-imide compounds |
US6046206A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
US6262059B1 (en) * | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
NZ319158A (en) * | 1995-10-02 | 1999-10-28 | Hoffmann La Roche | Pyrimidine derivatives as 5ht2c-receptor antagonists |
US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
GB9713087D0 (en) | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
US6191123B1 (en) | 1999-03-19 | 2001-02-20 | Parker Hughes Institute | Organic-arsenic compounds |
GB9929685D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
AU2001244688A1 (en) | 2000-03-31 | 2001-10-08 | Nippon Shinyaku Co. Ltd. | Heterocycle derivatives and drugs |
RU2003130752A (ru) | 2001-03-19 | 2005-03-10 | Ниппон Синяку Ко., Лтд. (Jp) | Противозудные средства |
WO2005014727A1 (en) * | 2003-07-17 | 2005-02-17 | Ciba Specialty Chemicals Holding Inc. | Black pigment compositions |
EP1648455A4 (en) | 2003-07-23 | 2009-03-04 | Exelixis Inc | MODULATORS OF ALK PROTEIN (ANAPLASTIC LYMPHOMA KINASE) AND METHODS OF USE |
CN1897950A (zh) * | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
KR100887264B1 (ko) | 2003-12-02 | 2009-03-06 | 테바 파마슈티컬 인더스트리즈 리미티드 | 로수바스타틴의 특성화를 위한 기준 표준물 |
US7169802B2 (en) * | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
ATE455777T1 (de) * | 2004-07-23 | 2010-02-15 | Medicines Co Leipzig Gmbh | Substituierte pyridoä3',2':4,5üthienoä3,2- düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü- pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung |
ZA200706530B (en) | 2005-02-09 | 2009-01-28 | Arqule Inc | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
MX2008002648A (es) | 2005-08-24 | 2008-03-14 | Protherics Medicines Dev Ltd | Escision de compuestos antifolato. |
ES2473344T3 (es) | 2006-02-15 | 2014-07-04 | Abbvie Inc. | Las pirazoloquinolonas son potentes inhibidoras de la PARP |
US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
US8906922B2 (en) | 2006-12-29 | 2014-12-09 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as AXl inhibitors |
-
2009
- 2009-12-30 JP JP2011544603A patent/JP5739820B2/ja active Active
- 2009-12-30 ES ES09793690.0T patent/ES2554623T3/es active Active
- 2009-12-30 KR KR1020117017777A patent/KR101714799B1/ko active IP Right Grant
- 2009-12-30 CA CA2748491A patent/CA2748491C/en active Active
- 2009-12-30 MX MX2011006959A patent/MX2011006959A/es active IP Right Grant
- 2009-12-30 WO PCT/US2009/069813 patent/WO2010078421A1/en active Application Filing
- 2009-12-30 DK DK09793690.0T patent/DK2379506T3/en active
- 2009-12-30 TW TW098145881A patent/TWI461410B/zh active
- 2009-12-30 EP EP09793690.0A patent/EP2379506B1/en active Active
- 2009-12-30 CN CN200980156889.XA patent/CN102325755B/zh active Active
- 2009-12-30 US US12/649,573 patent/US8357694B2/en active Active
- 2009-12-30 BR BRPI0923786A patent/BRPI0923786C8/pt active IP Right Grant
-
2011
- 2011-06-24 ZA ZA2011/04706A patent/ZA201104706B/en unknown
- 2011-06-27 IL IL213787A patent/IL213787A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ES2554623T3 (es) | 2015-12-22 |
IL213787A (en) | 2014-08-31 |
AU2009335010A1 (en) | 2011-07-21 |
JP5739820B2 (ja) | 2015-06-24 |
CA2748491A1 (en) | 2010-07-08 |
MX2011006959A (es) | 2011-12-06 |
EP2379506A1 (en) | 2011-10-26 |
JP2012514045A (ja) | 2012-06-21 |
TW201035055A (en) | 2010-10-01 |
AU2009335010A8 (en) | 2011-08-11 |
BRPI0923786C1 (pt) | 2021-05-11 |
TWI461410B (zh) | 2014-11-21 |
DK2379506T3 (en) | 2015-12-14 |
CN102325755A (zh) | 2012-01-18 |
WO2010078421A1 (en) | 2010-07-08 |
WO2010078421A8 (en) | 2011-10-27 |
ZA201104706B (en) | 2012-08-29 |
KR20110099790A (ko) | 2011-09-08 |
CN102325755B (zh) | 2015-07-01 |
US20100239525A1 (en) | 2010-09-23 |
IL213787A0 (en) | 2011-07-31 |
US8357694B2 (en) | 2013-01-22 |
BRPI0923786A2 (pt) | 2016-07-26 |
CA2748491C (en) | 2019-08-06 |
EP2379506B1 (en) | 2015-09-02 |
KR101714799B1 (ko) | 2017-03-09 |
BRPI0923786B1 (pt) | 2020-11-24 |
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