BRPI0614039A2 - inibidores isotopicamente substituìdos da bomba de prótons - Google Patents

inibidores isotopicamente substituìdos da bomba de prótons Download PDF

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Publication number
BRPI0614039A2
BRPI0614039A2 BRPI0614039-4A BRPI0614039A BRPI0614039A2 BR PI0614039 A2 BRPI0614039 A2 BR PI0614039A2 BR PI0614039 A BRPI0614039 A BR PI0614039A BR PI0614039 A2 BRPI0614039 A2 BR PI0614039A2
Authority
BR
Brazil
Prior art keywords
methoxy
formula
benzimidazole
compounds
hydrogen
Prior art date
Application number
BRPI0614039-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Bernhard Kohl
Bernd Mueller
Dieter Haag
Wolfgang-Alexander Simon
Karl Zech
Michael David
Richter Oliver Von
Felix Huth
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of BRPI0614039A2 publication Critical patent/BRPI0614039A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/69Two or more oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BRPI0614039-4A 2005-07-26 2006-07-26 inibidores isotopicamente substituìdos da bomba de prótons BRPI0614039A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106868.2 2005-07-26
EP05106868 2005-07-26
PCT/EP2006/064666 WO2007012650A1 (en) 2005-07-26 2006-07-26 Isotopically substituted proton pump inhibitors

Publications (1)

Publication Number Publication Date
BRPI0614039A2 true BRPI0614039A2 (pt) 2011-03-09

Family

ID=35734406

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614039-4A BRPI0614039A2 (pt) 2005-07-26 2006-07-26 inibidores isotopicamente substituìdos da bomba de prótons

Country Status (17)

Country Link
EP (1) EP1910293A1 (ru)
JP (1) JP5448448B2 (ru)
KR (1) KR101358509B1 (ru)
CN (2) CN101268051B (ru)
AR (1) AR054584A1 (ru)
AU (1) AU2006274036B2 (ru)
BR (1) BRPI0614039A2 (ru)
CA (1) CA2615670C (ru)
EA (1) EA016814B1 (ru)
HK (2) HK1125098A1 (ru)
IL (1) IL188773A (ru)
MX (1) MX2008000901A (ru)
NO (1) NO20080839L (ru)
NZ (1) NZ565078A (ru)
TW (1) TWI394750B (ru)
WO (1) WO2007012650A1 (ru)
ZA (1) ZA200800303B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101268050B (zh) * 2005-07-26 2012-11-28 奈科明有限责任公司 同位素取代的泮托拉唑
WO2007041630A1 (en) 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US20080255200A1 (en) * 2007-04-11 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
WO2008127640A2 (en) * 2007-04-11 2008-10-23 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
KR20120114356A (ko) 2010-02-12 2012-10-16 에스티브 퀴미카 에스.에이. 에스오메프라졸 나트륨염의 제조공정
CN104530003A (zh) * 2014-06-10 2015-04-22 广东东阳光药业有限公司 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
BR9507200A (pt) * 1994-03-25 1997-09-16 Isotechnika Inc Melhora da eficácia de drogas por deuteração
US6884429B2 (en) * 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE10123129A1 (de) * 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10162121A1 (de) * 2001-12-12 2003-06-18 Berolina Drug Dev Ab Svedala Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel
CN101268050B (zh) * 2005-07-26 2012-11-28 奈科明有限责任公司 同位素取代的泮托拉唑

Also Published As

Publication number Publication date
AU2006274036B2 (en) 2012-05-24
EA016814B1 (ru) 2012-07-30
HK1160126A1 (en) 2012-08-10
WO2007012650A1 (en) 2007-02-01
TWI394750B (zh) 2013-05-01
MX2008000901A (es) 2008-03-26
NO20080839L (no) 2008-02-18
AU2006274036A1 (en) 2007-02-01
HK1125098A1 (en) 2009-07-31
CA2615670A1 (en) 2007-02-01
TW200714596A (en) 2007-04-16
IL188773A (en) 2014-02-27
AR054584A1 (es) 2007-06-27
KR20080037676A (ko) 2008-04-30
CN101268051B (zh) 2011-08-31
AU2006274036A2 (en) 2008-03-20
CN102134232A (zh) 2011-07-27
EP1910293A1 (en) 2008-04-16
EA200800203A1 (ru) 2008-08-29
CA2615670C (en) 2015-01-20
JP2009502871A (ja) 2009-01-29
CN101268051A (zh) 2008-09-17
JP5448448B2 (ja) 2014-03-19
ZA200800303B (en) 2009-01-28
CN102134232B (zh) 2012-11-21
NZ565078A (en) 2010-03-26
IL188773A0 (en) 2008-08-07
KR101358509B1 (ko) 2014-02-05

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: TAKEDA GMBH (DE)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.