BRPI0520587A2 - uso de derivados de ftalida e composição farmacêutica contendo os mesmos - Google Patents

uso de derivados de ftalida e composição farmacêutica contendo os mesmos

Info

Publication number
BRPI0520587A2
BRPI0520587A2 BRPI0520587-5A BRPI0520587A BRPI0520587A2 BR PI0520587 A2 BRPI0520587 A2 BR PI0520587A2 BR PI0520587 A BRPI0520587 A BR PI0520587A BR PI0520587 A2 BRPI0520587 A2 BR PI0520587A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
composition containing
derivatives
phthalide derivatives
phthalide
Prior art date
Application number
BRPI0520587-5A
Other languages
English (en)
Inventor
Fei Chen
Tao Wang
Original Assignee
Fei Chen
Tao Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fei Chen, Tao Wang filed Critical Fei Chen
Publication of BRPI0520587A2 publication Critical patent/BRPI0520587A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USO DE DERIVADOS DE FTALIDA E COMPOSIçãO FARMACêUTICA CONTENDO OS MESMOS. A presente invenção refere-se a derivados de ftalida e o uso dos mesmos na fabricação de sensibilizadores ou reversores de fármacos antitumorais. Os derivados de ftalida da presente invenção podem superar ou aliviar resistência a múltiplos fármacos, aumentar a inibição a crescimento induzido por fármacos quimioterapêuticos em 5-30 vezes, e também promover significativamente a morte de células tumorais induzida por fármacos quimioterapêuticos.
BRPI0520587-5A 2005-09-30 2005-09-30 uso de derivados de ftalida e composição farmacêutica contendo os mesmos BRPI0520587A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2005/001627 WO2007036074A1 (fr) 2005-09-30 2005-09-30 Utilisation de dérivés du phthalide

Publications (1)

Publication Number Publication Date
BRPI0520587A2 true BRPI0520587A2 (pt) 2009-05-19

Family

ID=37899346

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520587-5A BRPI0520587A2 (pt) 2005-09-30 2005-09-30 uso de derivados de ftalida e composição farmacêutica contendo os mesmos

Country Status (9)

Country Link
US (1) US8445532B2 (pt)
EP (1) EP1932527A4 (pt)
JP (1) JP5356029B2 (pt)
CN (1) CN101272779B (pt)
AU (1) AU2005336866B2 (pt)
BR (1) BRPI0520587A2 (pt)
CA (1) CA2624150A1 (pt)
MX (1) MX2008004244A (pt)
WO (1) WO2007036074A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2106795A4 (en) * 2007-01-19 2010-09-08 Chen Fei USE OF PHTHALID DIPOLYMERS AGAINST TUMORS
US10987339B2 (en) 2015-08-19 2021-04-27 Everfront Biotech Inc. Uses of butylidenephthalide
CN106466315B (zh) * 2015-08-19 2021-04-06 长弘生物科技股份有限公司 亚丁基苯酞的用途
CN111825646B (zh) * 2019-04-17 2022-12-09 江苏康缘药业股份有限公司 一种丁基苯肽类化合物及其制备方法和应用
US20230092846A1 (en) * 2020-01-14 2023-03-23 Everfront Biotech Inc. Combination for the treatment of cancer and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2792010B2 (ja) * 1989-11-14 1998-08-27 カゴメ株式会社 フタリド誘導体及びこれを有効成分とする子宮頚癌細胞の殺細胞剤
CN1052407C (zh) * 1992-11-25 2000-05-17 黑龙江省肿瘤医院 一种肿瘤化疗中药增效剂及其制备方法
JP3157379B2 (ja) * 1994-02-18 2001-04-16 長谷川香料株式会社 外観、食感の改善された粉末食品素材
CN1064836C (zh) * 1997-04-24 2001-04-25 中国医学科学院医药生物技术研究所 当归内酯作为生物反应调节剂在制备抗肿瘤药物中的应用
US20040092583A1 (en) * 2001-01-02 2004-05-13 Elizabeth Shanahan-Prendergast Treatment for inhibiting neoplastic lesions
ATE319462T1 (de) * 2001-04-02 2006-03-15 Hongfen Li Antineoplastisches arzneimittel
DE60330679D1 (de) * 2002-08-20 2010-02-04 Univ Singapore Phytoprogestogenen extrakten aus rhizoma ligusticum chuanxiong und ihre verwendungszwecke
CN1569848A (zh) 2003-07-14 2005-01-26 中国中医研究院中药研究所 治疗缺血性心脏病的川芎内酯及其制备方法
CN1331469C (zh) * 2004-04-05 2007-08-15 王弢 一种苯酞类二聚体的用途
US20060110469A1 (en) * 2004-10-08 2006-05-25 Buddhist Tzu Chi General Hospital Angelicae sinensis extracts useful for treatment of cancers

Also Published As

Publication number Publication date
JP2009511436A (ja) 2009-03-19
MX2008004244A (es) 2009-02-04
JP5356029B2 (ja) 2013-12-04
CN101272779A (zh) 2008-09-24
EP1932527A4 (en) 2010-01-27
CA2624150A1 (en) 2007-04-05
US20080255061A1 (en) 2008-10-16
CN101272779B (zh) 2012-09-05
AU2005336866B2 (en) 2012-06-14
EP1932527A1 (en) 2008-06-18
US8445532B2 (en) 2013-05-21
WO2007036074A1 (fr) 2007-04-05
AU2005336866A1 (en) 2007-04-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.