BRPI0818672B8 - composições, composições farmacêuticas e usos de 2'flúor-2'-desoxitetra-hidrouridinas - Google Patents

composições, composições farmacêuticas e usos de 2'flúor-2'-desoxitetra-hidrouridinas

Info

Publication number
BRPI0818672B8
BRPI0818672B8 BRPI0818672A BRPI0818672A BRPI0818672B8 BR PI0818672 B8 BRPI0818672 B8 BR PI0818672B8 BR PI0818672 A BRPI0818672 A BR PI0818672A BR PI0818672 A BRPI0818672 A BR PI0818672A BR PI0818672 B8 BRPI0818672 B8 BR PI0818672B8
Authority
BR
Brazil
Prior art keywords
compositions
pharmaceutical compositions
deoxytetrahydrouridines
fluor
compounds
Prior art date
Application number
BRPI0818672A
Other languages
English (en)
Inventor
Duvall Bridget
V Ferraris Dana
S Hamilton Gregory
Lapidus Rena
Tsukamoto Takashi
Original Assignee
Eisai Inc
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Inc, Otsuka Pharma Co Ltd filed Critical Eisai Inc
Publication of BRPI0818672A2 publication Critical patent/BRPI0818672A2/pt
Publication of BRPI0818672B1 publication Critical patent/BRPI0818672B1/pt
Publication of BRPI0818672B8 publication Critical patent/BRPI0818672B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

compostos 2'-flúor-2'-desoxitetra-hidrouridinas, uso dos mesmos e composições farmacêuticas. a presente invenção refere-se a alguns compostos de derivados de tetra-hidrouridina, a composições farmacêuticas e a kits que compreendem tais compostos e a métodos de fabricação e uso de tais compostos.
BRPI0818672A 2007-10-16 2008-10-16 composições, composições farmacêuticas e usos de 2'flúor-2'-desoxitetra-hidrouridinas BRPI0818672B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98039707P 2007-10-16 2007-10-16
US60/980,397 2007-10-16
PCT/US2008/080163 WO2009052287A1 (en) 2007-10-16 2008-10-16 2 ' -flu0r0-2 ' -deoxytetrahydrouridines as cytidine deaminase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0818672A2 BRPI0818672A2 (pt) 2015-04-14
BRPI0818672B1 BRPI0818672B1 (pt) 2020-10-20
BRPI0818672B8 true BRPI0818672B8 (pt) 2021-05-25

Family

ID=40251685

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0818672A BRPI0818672B8 (pt) 2007-10-16 2008-10-16 composições, composições farmacêuticas e usos de 2'flúor-2'-desoxitetra-hidrouridinas

Country Status (39)

Country Link
US (4) US8268800B2 (pt)
EP (2) EP2447272B1 (pt)
JP (2) JP5496899B2 (pt)
KR (1) KR101543049B1 (pt)
CN (1) CN101827856B (pt)
AT (1) ATE548374T1 (pt)
BR (1) BRPI0818672B8 (pt)
CA (1) CA2702274C (pt)
CO (1) CO6270330A2 (pt)
CR (1) CR11427A (pt)
CY (3) CY1112781T1 (pt)
DK (1) DK2207786T3 (pt)
EA (1) EA018757B1 (pt)
EC (1) ECSP10010095A (pt)
ES (2) ES2384011T3 (pt)
FI (2) FIC20230040I1 (pt)
FR (2) FR23C1052I1 (pt)
GT (1) GT201000088A (pt)
HK (1) HK1146410A1 (pt)
HR (1) HRP20120419T1 (pt)
HU (2) HUS2300045I1 (pt)
IL (1) IL204732A (pt)
JO (1) JO2778B1 (pt)
ME (1) ME00997B (pt)
MX (1) MX2010004109A (pt)
MY (1) MY147970A (pt)
NI (1) NI201000055A (pt)
NL (1) NL301256I2 (pt)
NO (2) NO2023047I1 (pt)
NZ (1) NZ584229A (pt)
PL (1) PL2207786T3 (pt)
PT (1) PT2207786E (pt)
RS (1) RS52323B (pt)
SA (1) SA08290661B1 (pt)
SI (1) SI2207786T1 (pt)
TW (1) TWI445539B (pt)
UA (1) UA99476C2 (pt)
WO (1) WO2009052287A1 (pt)
ZA (1) ZA201002178B (pt)

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NZ584229A (en) 2012-06-29
CA2702274A1 (en) 2009-04-23
ZA201002178B (en) 2011-05-25
NI201000055A (es) 2010-08-13
EP2447272A1 (en) 2012-05-02
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