BRPI0517035A - novos compostos - Google Patents

novos compostos

Info

Publication number
BRPI0517035A
BRPI0517035A BRPI0517035-4A BRPI0517035A BRPI0517035A BR PI0517035 A BRPI0517035 A BR PI0517035A BR PI0517035 A BRPI0517035 A BR PI0517035A BR PI0517035 A BRPI0517035 A BR PI0517035A
Authority
BR
Brazil
Prior art keywords
compounds
new compounds
preparing
pharmaceutical compositions
processes
Prior art date
Application number
BRPI0517035-4A
Other languages
English (en)
Inventor
Balint Gabos
Michael Lundkvist
Igor Shamovsky
Munck Af Rosenschoeld
Pavol Zlatoidsky Magnus
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0517035A publication Critical patent/BRPI0517035A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

NOVOS COMPOSTOS. A presente invenção proporciona compostos de fórmula (1) onde R˜, R , A, A˜ e B são como definido no presente relatório descritivo. A invenção também proporciona processos para preparação de tais compostos, composições farmacêuticas contendo os mesmos, processo para preparação das composições farmacêuticas e seu uso em terapia. Os presentes compostos são de utilidade como inibidores de metaloproteinases (MMP).
BRPI0517035-4A 2004-12-17 2005-12-14 novos compostos BRPI0517035A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0403085A SE0403085D0 (sv) 2004-12-17 2004-12-17 Novel componds
PCT/SE2005/001917 WO2006065215A1 (en) 2004-12-17 2005-12-14 Novel compounds

Publications (1)

Publication Number Publication Date
BRPI0517035A true BRPI0517035A (pt) 2008-09-30

Family

ID=34075235

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517035-4A BRPI0517035A (pt) 2004-12-17 2005-12-14 novos compostos

Country Status (23)

Country Link
US (2) US7655664B2 (pt)
EP (1) EP1831199B1 (pt)
JP (1) JP2008524210A (pt)
KR (1) KR20070090924A (pt)
CN (1) CN101119987A (pt)
AR (1) AR051795A1 (pt)
AT (1) ATE545642T1 (pt)
AU (1) AU2005317286B2 (pt)
BR (1) BRPI0517035A (pt)
CA (1) CA2590845A1 (pt)
ES (1) ES2380670T3 (pt)
IL (1) IL183599A (pt)
MX (1) MX2007007023A (pt)
MY (1) MY147770A (pt)
NO (1) NO20073572L (pt)
NZ (1) NZ555831A (pt)
RU (1) RU2376301C2 (pt)
SA (1) SA05260409B1 (pt)
SE (1) SE0403085D0 (pt)
TW (1) TW200635917A (pt)
UA (1) UA90285C2 (pt)
WO (1) WO2006065215A1 (pt)
ZA (1) ZA200705075B (pt)

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SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
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SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
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TW200740769A (en) * 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
KR101271219B1 (ko) * 2011-01-27 2013-06-07 광주과학기술원 신규한 하이단토인 유도체 및 이의 용도
RU2650678C2 (ru) * 2013-12-31 2018-04-17 Ипсен Фарма С.А.С. Новые производные имидазолидин-2,4-дионов
JPWO2018117196A1 (ja) 2016-12-20 2019-10-31 大日本住友製薬株式会社 がん幹細胞を標的とする医薬
TW202202495A (zh) 2020-03-26 2022-01-16 匈牙利商羅特格登公司 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物
WO2023231964A1 (zh) * 2022-05-30 2023-12-07 赛诺哈勃药业（成都）有限公司 四氢萘啶衍生物在制备防治粘连相关疾病的药物中的应用

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Also Published As

Publication number Publication date
KR20070090924A (ko) 2007-09-06
EP1831199A1 (en) 2007-09-12
CA2590845A1 (en) 2006-06-22
AU2005317286B2 (en) 2009-02-05
MX2007007023A (es) 2007-09-11
AR051795A1 (es) 2007-02-07
RU2007126746A (ru) 2009-01-27
TW200635917A (en) 2006-10-16
US20080293743A1 (en) 2008-11-27
IL183599A0 (en) 2007-09-20
ZA200705075B (en) 2008-12-31
NO20073572L (no) 2007-09-12
WO2006065215A1 (en) 2006-06-22
RU2376301C2 (ru) 2009-12-20
AU2005317286A1 (en) 2006-06-22
EP1831199B1 (en) 2012-02-15
ATE545642T1 (de) 2012-03-15
CN101119987A (zh) 2008-02-06
JP2008524210A (ja) 2008-07-10
ES2380670T3 (es) 2012-05-17
US20100256166A1 (en) 2010-10-07
SE0403085D0 (sv) 2004-12-17
UA90285C2 (ru) 2010-04-26
NZ555831A (en) 2011-01-28
SA05260409B1 (ar) 2009-03-14
MY147770A (en) 2013-01-31
IL183599A (en) 2012-02-29
US7655664B2 (en) 2010-02-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.