BRPI0506883A - miméticos de smac conformacionalmente comprimidos e seus usos - Google Patents
miméticos de smac conformacionalmente comprimidos e seus usosInfo
- Publication number
- BRPI0506883A BRPI0506883A BRPI0506883-5A BRPI0506883A BRPI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A
- Authority
- BR
- Brazil
- Prior art keywords
- compressed
- smac mimetics
- conformational
- mimetics
- smac
- Prior art date
Links
- 229940075439 smac mimetic Drugs 0.000 title abstract 3
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 abstract 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 abstract 1
- 230000001640 apoptogenic effect Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001235 sensitizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Abstract
MIMéTICOS DE SMAC CONFORMACIONALMENTE COMPRIMIDOS E SEUS USOS A invenção refere-se a miméticos de Smac conformacionalmente comprimidos que funcionam como inibidores de Proteínas Inibidoras de Apoptose. A invenção também se refere ao uso destes miméticos para indução de morte celular apoptótica e para sensibilizar células indutoras de apoptose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53714004P | 2004-01-16 | 2004-01-16 | |
PCT/US2005/001406 WO2005069894A2 (en) | 2004-01-16 | 2005-01-18 | Conformationally constrained smac mimetics and the uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506883A true BRPI0506883A (pt) | 2007-05-29 |
Family
ID=34807084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506883-5A BRPI0506883A (pt) | 2004-01-16 | 2005-01-18 | miméticos de smac conformacionalmente comprimidos e seus usos |
Country Status (9)
Country | Link |
---|---|
US (1) | US7932382B2 (pt) |
EP (1) | EP1718300A4 (pt) |
JP (1) | JP2007522116A (pt) |
CN (1) | CN1960728A (pt) |
AU (1) | AU2005206929B2 (pt) |
BR (1) | BRPI0506883A (pt) |
CA (1) | CA2553874A1 (pt) |
MX (1) | MXPA06008095A (pt) |
WO (1) | WO2005069894A2 (pt) |
Families Citing this family (92)
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MX2007000490A (es) * | 2004-07-12 | 2007-06-11 | Idun Pharmaceuticals Inc | Analogos de tetrapeptido. |
EP1773766B1 (en) | 2004-07-15 | 2014-04-02 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
CN101146803A (zh) | 2004-12-20 | 2008-03-19 | 健泰科生物技术公司 | Iap的吡咯烷抑制剂 |
DK1851200T3 (da) | 2005-02-25 | 2014-04-14 | Tetralogic Pharm Corp | Dimere iap-inhibitorer |
AU2006255084A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | Organic compounds |
CN101374829A (zh) | 2005-12-19 | 2009-02-25 | 健泰科生物技术公司 | Iap的抑制剂 |
BRPI0620058A2 (pt) | 2005-12-20 | 2011-11-01 | Novartis Ag | combinação farmacêutica compreendendo compostos inibidores da ligação da proteìna smac a proteìnas inibidoras de apoptose, e um taxano, bem como uso da mesma |
US8202902B2 (en) | 2006-05-05 | 2012-06-19 | The Regents Of The University Of Michigan | Bivalent SMAC mimetics and the uses thereof |
CA2651206C (en) | 2006-05-05 | 2013-11-12 | Shaomeng Wang | Bivalent smac mimetics and the uses thereof |
WO2008014229A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
AR064235A1 (es) | 2006-07-24 | 2009-03-25 | Tetralogic Pharmaceuticals Cor | Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer |
EP2049563B1 (en) | 2006-07-24 | 2014-03-12 | Tetralogic Pharmaceuticals Corporation | Dimeric iap antagonists |
HUE024142T2 (en) * | 2007-04-13 | 2016-02-29 | Univ Michigan Regents | Bicyclic diazo-SMAC mimetics and their use |
NZ598890A (en) | 2007-04-30 | 2013-10-25 | Genentech Inc | Inhibitors of iap |
JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてTNFα遺伝子の発現を用いる方法 |
EP2058312A1 (en) * | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
JP5887134B2 (ja) * | 2008-04-11 | 2016-03-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ヘテロアリールによって置換されている二環式のSmacの模倣物 |
AU2009279924B2 (en) * | 2008-08-02 | 2014-10-02 | Genentech, Inc. | Inhibitors of IAP |
CN105574346A (zh) * | 2008-09-05 | 2016-05-11 | 新基阿维罗米克斯研究公司 | 多肽偶联物与不可逆抑制剂的设计方法和检测方法 |
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WO2014085489A1 (en) * | 2012-11-30 | 2014-06-05 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
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GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
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US20150375009A1 (en) * | 2014-06-28 | 2015-12-31 | Eugene R. Moore | Treating and preventing virus infections in animals |
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MX2017009454A (es) | 2015-01-20 | 2017-10-20 | Arvinas Inc | Compuestos y metodos para la degradacion dirigida de receptor de androgenos. |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
IT1277405B1 (it) | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
US6608026B1 (en) * | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
ES2524449T3 (es) | 2004-07-02 | 2014-12-09 | Genentech, Inc. | Inhibidores de IAP |
-
2005
- 2005-01-18 MX MXPA06008095A patent/MXPA06008095A/es not_active Application Discontinuation
- 2005-01-18 CA CA002553874A patent/CA2553874A1/en not_active Abandoned
- 2005-01-18 EP EP05711521A patent/EP1718300A4/en not_active Ceased
- 2005-01-18 JP JP2006549661A patent/JP2007522116A/ja not_active Withdrawn
- 2005-01-18 AU AU2005206929A patent/AU2005206929B2/en not_active Ceased
- 2005-01-18 US US10/586,271 patent/US7932382B2/en active Active
- 2005-01-18 BR BRPI0506883-5A patent/BRPI0506883A/pt not_active IP Right Cessation
- 2005-01-18 CN CNA200580008403XA patent/CN1960728A/zh active Pending
- 2005-01-18 WO PCT/US2005/001406 patent/WO2005069894A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US7932382B2 (en) | 2011-04-26 |
JP2007522116A (ja) | 2007-08-09 |
AU2005206929B2 (en) | 2008-01-24 |
WO2005069894A2 (en) | 2005-08-04 |
MXPA06008095A (es) | 2007-03-28 |
WO2005069894A3 (en) | 2005-10-06 |
EP1718300A4 (en) | 2008-05-14 |
CN1960728A (zh) | 2007-05-09 |
US20080269140A1 (en) | 2008-10-30 |
EP1718300A2 (en) | 2006-11-08 |
CA2553874A1 (en) | 2005-08-04 |
AU2005206929A1 (en) | 2005-08-04 |
WO2005069894A8 (en) | 2007-01-04 |
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