BRPI0506765A - composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composição - Google Patents
composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composiçãoInfo
- Publication number
- BRPI0506765A BRPI0506765A BRPI0506765-0A BRPI0506765A BRPI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- compound
- phenyl
- lower alkyl
- composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
COMPOSTO OU UM SEU SAL, HIDRATO E/OU PRó-DROGAFARMACêUTICAMENTE ACEITáVEIS, COMPOSIçãO FARMACêUTICA, MéTODOS PARA INIBIR A PRODUçãO DE BETA-AMILóIDE EM UM PACIENTE E PARA TRATAR DE UMA DOENçA, KIT FARMACêUTICO, USO DE UM COMPOSTO OU DE UMA COMPOSIçãO Composto úteis para reduzir os níveis da beta - amilióde são providos. Os compostos têm a estrutura de fórmula Ia: em que R~ 1~ é alquila inferior, alquila inferior substituída fenila,fenila substituída, benzila, benzila substituída, benzilóxi, benzilóxi substituído, ou SO~ 2~ R~ 5~; R~ 5~ é fenila, fenila substituída, heterociclo, heterociclo susbstituído, alquila ou alquila substituída; R~ 2~é alquila inferior, alquila inferior substituída, CF~ 3~ alquenila, alquenila substituída, alquinila, alquinila substitúida, fenila, fenila substituída ou cicloalquila;R~ 3~ é hidrogênio, alquila inferior ou alquila inferior substituída; R~4~ é fenila, fenila substituída, heteroclico, heteroclicosubstituído, tiofeno ou tiofeno substituído; R~ 6~ é hidrogênio, alquila inferior, alquila inferior substituída, CF~ 3~, alquenila, alquenila substituída,alquinila,alquinila substituída, fenila, fenila substituída, cicloalquila ou cicloalquila substituída W,X,Y são independentes CR~ 7~ ou N; e R~ 7~ é hidrogênio, halogênio, alquila inferior ou alquila inferior substituída
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53708604P | 2004-01-16 | 2004-01-16 | |
PCT/US2005/001082 WO2005073198A1 (en) | 2004-01-16 | 2005-01-13 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506765A true BRPI0506765A (pt) | 2007-05-22 |
Family
ID=34825912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506765-0A BRPI0506765A (pt) | 2004-01-16 | 2005-01-13 | composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composição |
Country Status (11)
Country | Link |
---|---|
US (3) | US7399778B2 (pt) |
EP (1) | EP1709003B1 (pt) |
JP (1) | JP2007517905A (pt) |
CN (1) | CN1910158A (pt) |
AT (1) | ATE443701T1 (pt) |
AU (1) | AU2005207835A1 (pt) |
BR (1) | BRPI0506765A (pt) |
CA (1) | CA2552558A1 (pt) |
DE (1) | DE602005016775D1 (pt) |
ES (1) | ES2330451T3 (pt) |
WO (1) | WO2005073198A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2321394C2 (ru) * | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
WO2004092155A1 (en) * | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
MXPA06014909A (es) * | 2004-06-18 | 2007-02-28 | Chiron Corp | Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer. |
RU2008129797A (ru) * | 2006-02-17 | 2010-03-27 | Вайет (Us) | Способы получения сульфонамид-замещенных спиртов и их промежуточных соединений |
CN101384579A (zh) * | 2006-02-17 | 2009-03-11 | 惠氏公司 | 2-氨基三氟烷基取代的醇的选择性n-磺酰化 |
EP2013184A1 (en) * | 2006-04-21 | 2009-01-14 | AstraZeneca AB | Sulfonamide compounds useful as edg receptor modulators |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
CA2649396A1 (en) * | 2006-04-21 | 2007-11-08 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
CA2667802A1 (en) * | 2006-11-03 | 2008-05-29 | Northwestern University | Multiple sclerosis therapy |
CL2008002059A1 (es) * | 2007-07-16 | 2008-11-14 | Wyeth Corp | Método de preparación de sulfonamidas heterocíclicas; los compuestos intermediarios usados en el método descrito; y los métodos de preparación de dichos intermediarios. |
EP2193117A1 (en) * | 2007-07-16 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Inhibitors of beta amyloid production |
AR067534A1 (es) * | 2007-07-16 | 2009-10-14 | Wyeth Corp | Proceso para la preparacion de trifluoroalquil - fenil sulfonamidas y de sulfonamidas heterociclicas |
AR070120A1 (es) * | 2008-01-11 | 2010-03-17 | Wyeth Corp | Derivados de aril sulfonamida que contienen o-sulfato y o-fosfato, utiles como inhibidores de beta-amiloide, proceso de preparacion de los mismos y composiciones farmaceuticas que los contienen. |
CA2718411C (en) | 2008-03-27 | 2016-02-16 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
MX2012003207A (es) | 2009-09-18 | 2012-05-29 | Chase Pharmaceuticals Corp | Metodo y composicion para tratar la demencia de tipo alzheimer. |
JP2011043839A (ja) * | 2010-09-29 | 2011-03-03 | Panasonic Corp | レジスト材料及びそれを用いたパターン形成方法 |
CN102786447A (zh) * | 2011-08-01 | 2012-11-21 | 四川大学 | N,n-二取代芳基磺酰胺类化合物及其制备方法和用途 |
CN104768540A (zh) | 2012-09-05 | 2015-07-08 | 才思制药公司 | 抗胆碱能神经保护组合物和方法 |
CA2951784C (en) * | 2014-06-10 | 2022-05-31 | Ube Industries, Ltd. | N-substituted sulfonamide compound and method for producing same |
US10774072B2 (en) | 2014-06-10 | 2020-09-15 | Ube Industries, Ltd. | Crystal of N-substituted sulfonamide compound |
JP6572890B2 (ja) | 2014-06-10 | 2019-09-11 | 宇部興産株式会社 | ヘテロ芳香族スルホンアミド化合物の製造方法 |
WO2016179558A1 (en) | 2015-05-06 | 2016-11-10 | The Regents Of The University Of California | K-ras modulators |
CA3059943A1 (en) | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
WO2019204505A2 (en) * | 2018-04-18 | 2019-10-24 | Theras, Inc. | K-ras modulators with a vinyl sulfonamide moiety |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9200209D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
NZ264143A (en) | 1993-08-09 | 1996-11-26 | Lilly Co Eli | Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production |
CA2238175A1 (en) * | 1995-11-28 | 1997-06-19 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
HUP0001383A3 (en) | 1996-11-22 | 2001-11-28 | Lilly Co Eli | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use |
WO1999012910A1 (fr) * | 1997-09-11 | 1999-03-18 | Nissan Chemical Industries, Ltd. | Composes a base de pyrazole et agent de lutte contre les maladies vegetales |
AU773273B2 (en) | 1999-02-26 | 2004-05-20 | Bristol-Myers Squibb Company | Novel sulfonamide compounds and uses thereof |
BR0013143A (pt) * | 1999-08-12 | 2002-06-11 | Pharmacia Italia Spa | Derivados de 3 (5) amino pirazol, processo para sua preparação e uso dos mesmos como agentes antitumorais |
EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
EP1222176A1 (en) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
JP2003528076A (ja) | 2000-03-20 | 2003-09-24 | メルク シャープ エンド ドーム リミテッド | スルホンアミド置換架橋ビシクロアルキル誘導体 |
AU2001264872A1 (en) * | 2000-06-05 | 2001-12-17 | Ortho-Mcneil Pharmaceutical, Inc. | Method for synthesis of substituted azole libraries |
NZ526213A (en) * | 2000-12-13 | 2005-05-27 | Wyeth Corp | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US6657070B2 (en) * | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
JP4615861B2 (ja) | 2001-12-11 | 2011-01-19 | ワイス・エルエルシー | キラル的に純粋なα−アミノ酸およびN−スルホニルα−アミノ酸の生産 |
DE10163582A1 (de) * | 2001-12-21 | 2003-07-03 | Thomson Brandt Gmbh | Automatische Verstärkungsregelung für einen Tuner |
WO2004092155A1 (en) * | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
-
2005
- 2005-01-13 CA CA002552558A patent/CA2552558A1/en not_active Abandoned
- 2005-01-13 AU AU2005207835A patent/AU2005207835A1/en not_active Abandoned
- 2005-01-13 US US11/035,005 patent/US7399778B2/en not_active Expired - Fee Related
- 2005-01-13 CN CNA2005800025879A patent/CN1910158A/zh active Pending
- 2005-01-13 JP JP2006549589A patent/JP2007517905A/ja active Pending
- 2005-01-13 BR BRPI0506765-0A patent/BRPI0506765A/pt not_active IP Right Cessation
- 2005-01-13 ES ES05705638T patent/ES2330451T3/es active Active
- 2005-01-13 AT AT05705638T patent/ATE443701T1/de not_active IP Right Cessation
- 2005-01-13 EP EP05705638A patent/EP1709003B1/en active Active
- 2005-01-13 DE DE602005016775T patent/DE602005016775D1/de active Active
- 2005-01-13 WO PCT/US2005/001082 patent/WO2005073198A1/en not_active Application Discontinuation
-
2008
- 2008-06-19 US US12/142,306 patent/US7674813B2/en not_active Expired - Fee Related
-
2010
- 2010-02-19 US US12/708,557 patent/US20100144812A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1910158A (zh) | 2007-02-07 |
ES2330451T3 (es) | 2009-12-10 |
EP1709003A1 (en) | 2006-10-11 |
US20100144812A1 (en) | 2010-06-10 |
DE602005016775D1 (de) | 2009-11-05 |
CA2552558A1 (en) | 2005-08-11 |
ATE443701T1 (de) | 2009-10-15 |
US7674813B2 (en) | 2010-03-09 |
AU2005207835A1 (en) | 2005-08-11 |
EP1709003B1 (en) | 2009-09-23 |
US20080249150A1 (en) | 2008-10-09 |
US7399778B2 (en) | 2008-07-15 |
WO2005073198A1 (en) | 2005-08-11 |
US20050171180A1 (en) | 2005-08-04 |
JP2007517905A (ja) | 2007-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |