HUP0001383A3 - N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use - Google Patents
N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their useInfo
- Publication number
- HUP0001383A3 HUP0001383A3 HU0001383A HUP0001383A HUP0001383A3 HU P0001383 A3 HUP0001383 A3 HU P0001383A3 HU 0001383 A HU0001383 A HU 0001383A HU P0001383 A HUP0001383 A HU P0001383A HU P0001383 A3 HUP0001383 A3 HU P0001383A3
- Authority
- HU
- Hungary
- Prior art keywords
- heteroaryl
- aryl
- amino acid
- same
- pharmaceutical compositions
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75533496A | 1996-11-22 | 1996-11-22 | |
PCT/US1997/018704 WO1998022493A2 (en) | 1996-11-22 | 1997-11-20 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001383A1 HUP0001383A1 (en) | 2001-05-28 |
HUP0001383A3 true HUP0001383A3 (en) | 2001-11-28 |
Family
ID=25038718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001383A HUP0001383A3 (en) | 1996-11-22 | 1997-11-20 | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0942923A2 (en) |
JP (1) | JP2001519769A (en) |
CN (1) | CN1237978A (en) |
AU (1) | AU5354398A (en) |
BR (1) | BR9714358A (en) |
CA (1) | CA2270876A1 (en) |
HU (1) | HUP0001383A3 (en) |
ID (1) | ID22275A (en) |
IL (1) | IL129477A0 (en) |
NO (1) | NO992426L (en) |
NZ (1) | NZ335157A (en) |
TR (1) | TR199901132T2 (en) |
WO (1) | WO1998022493A2 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
WO2000019210A2 (en) | 1998-09-30 | 2000-04-06 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
AU778005B2 (en) | 1998-12-24 | 2004-11-11 | Bristol-Myers Squibb Pharma Company | Succinoylamino benzodiazepines as inhibitors of Abeta protein production |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
EP1218377A1 (en) | 1999-10-08 | 2002-07-03 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
AU2001239791A1 (en) | 2000-02-17 | 2001-08-27 | Du Pont Pharmaceuticals Company | Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production |
CA2404023A1 (en) | 2000-04-03 | 2001-10-11 | Richard E. Olson | Cyclic lactams as inhibitors of a.beta. protein production |
WO2001074784A1 (en) | 2000-04-03 | 2001-10-11 | Dupont Pharmaceuticals Company | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION |
CA2404273A1 (en) | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
CN1386118A (en) | 2000-06-01 | 2002-12-18 | 布里斯托尔-迈尔斯斯奎布药品公司 | Lactams substituted by cyclic succinates as inhibitors of A beta protein production |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
HU230581B1 (en) | 2000-08-24 | 2017-01-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thioflavin derivatives and their use in diagnosis and treatment of alzheimer's disease |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
DE60121032T2 (en) | 2000-12-13 | 2007-01-11 | Wyeth | Heterocyclic Sulphonamides as Inhibitors of Beta-Amyloid Production |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
CH698246B1 (en) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test to identify inhibitors of beta secretases. |
DE10306202A1 (en) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
BRPI0408274B8 (en) * | 2003-03-14 | 2021-05-25 | Univ Pittsburgh | amyloid binding compounds and pharmaceutical composition |
WO2004092155A1 (en) | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
JP4220548B2 (en) | 2003-06-05 | 2009-02-04 | エラン ファーマシューティカルズ,インコーポレイテッド | Acylated amino acids, amidylpyrazole, and related compounds |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
AU2005207835A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
EP1725522B1 (en) | 2004-03-03 | 2014-09-10 | GlaxoSmithKline LLC | Aniline derivatives as selective androgen receptor modulators |
EP1871379A4 (en) * | 2005-04-15 | 2010-06-02 | Glaxosmithkline Llc | Cyanoarylamines |
CN100999546B (en) * | 2007-01-11 | 2010-08-11 | 清华大学 | Polypeptide compound with aza-containing heterocyclic modification and its application |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
CN111777571B (en) * | 2020-06-28 | 2023-07-11 | 武汉药明康德新药开发有限公司 | Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0721449B1 (en) * | 1993-10-01 | 2001-12-19 | Merrell Pharmaceuticals Inc. | Inhibitors of beta-amyloid protein production |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
-
1997
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/en unknown
- 1997-11-20 BR BR9714358A patent/BR9714358A/en not_active IP Right Cessation
- 1997-11-20 EP EP97950576A patent/EP0942923A2/en not_active Withdrawn
- 1997-11-20 JP JP52364998A patent/JP2001519769A/en active Pending
- 1997-11-20 CA CA002270876A patent/CA2270876A1/en not_active Abandoned
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/en not_active Application Discontinuation
- 1997-11-20 ID IDW990395A patent/ID22275A/en unknown
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/en unknown
- 1997-11-20 CN CN97199776A patent/CN1237978A/en active Pending
- 1997-11-20 NZ NZ335157A patent/NZ335157A/en unknown
- 1997-11-20 IL IL12947797A patent/IL129477A0/en unknown
-
1999
- 1999-05-20 NO NO992426A patent/NO992426L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL129477A0 (en) | 2000-02-29 |
AU5354398A (en) | 1998-06-10 |
HUP0001383A1 (en) | 2001-05-28 |
EP0942923A2 (en) | 1999-09-22 |
NO992426D0 (en) | 1999-05-20 |
JP2001519769A (en) | 2001-10-23 |
NZ335157A (en) | 2001-01-26 |
CA2270876A1 (en) | 1998-05-28 |
WO1998022493A3 (en) | 1998-07-23 |
TR199901132T2 (en) | 1999-08-23 |
NO992426L (en) | 1999-06-30 |
BR9714358A (en) | 2000-03-21 |
ID22275A (en) | 1999-09-23 |
WO1998022493A2 (en) | 1998-05-28 |
CN1237978A (en) | 1999-12-08 |
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