BRPI0416683A - muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21 - Google Patents
muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21Info
- Publication number
- BRPI0416683A BRPI0416683A BRPI0416683-3A BRPI0416683A BRPI0416683A BR PI0416683 A BRPI0416683 A BR PI0416683A BR PI0416683 A BRPI0416683 A BR PI0416683A BR PI0416683 A BRPI0416683 A BR PI0416683A
- Authority
- BR
- Brazil
- Prior art keywords
- fgf
- growth factor
- fibroblast growth
- human
- polynucleotide
- Prior art date
Links
- 102000018233 Fibroblast Growth Factor Human genes 0.000 title abstract 5
- 108050007372 Fibroblast Growth Factor Proteins 0.000 title abstract 5
- 229940126864 fibroblast growth factor Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title 2
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 208000028399 Critical Illness Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
Abstract
"MUTEìNA DE FATOR DE CRESCIMENTO DE FIBROBLASTO DE HUMANO 21 (FGF-21), OU UM SEU PEPTìDEO BIOLOGICAMENTE ATIVO, POLINUCLEOTìDEO, VETOR DE EXPRESSãO, CéLULA HOSPEDEIRA, PROCESSO PARA PRODUZIR UM POLIPEPTìDEO, COMPOSIçãO FARMACêUTICA, MéTODO PARA TRATAR UM PACIENTE, E, USO DA MUTEìNA FGF-21". A presente invenção refere-se às novas muteínas de fator de crescimento de fibroblasto de humano 21 com propriedades farmacêuticas melhoradas. São descritas tanto proteínas quanto espécies de ácido nucleico codificadoras respectivas. A invenção também tem por modalidades vetores e células hospedeiras para a propagação de citadas seqüências de ácido nucleico e a produção de citadas muteínas. Também são descritos métodos para tratar diabetes de tipo 2, obesidade, síndrome metabólica, e para reduzir a mortalidade e a morbidez de pacientes criticamente doentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52858203P | 2003-12-10 | 2003-12-10 | |
PCT/US2004/037200 WO2005061712A1 (en) | 2003-12-10 | 2004-12-01 | Muteins of fibroblast growth factor 21 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416683A true BRPI0416683A (pt) | 2007-01-30 |
Family
ID=34710086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416683-3A BRPI0416683A (pt) | 2003-12-10 | 2004-12-01 | muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21 |
Country Status (14)
Country | Link |
---|---|
US (2) | US7491697B2 (pt) |
EP (2) | EP2270163A1 (pt) |
JP (1) | JP4477013B2 (pt) |
KR (1) | KR20060135648A (pt) |
CN (1) | CN1890371A (pt) |
AR (1) | AR046877A1 (pt) |
AU (1) | AU2004303783A1 (pt) |
BR (1) | BRPI0416683A (pt) |
CA (1) | CA2549249A1 (pt) |
EA (1) | EA200601121A1 (pt) |
IL (1) | IL175736A0 (pt) |
NO (1) | NO20062662L (pt) |
TW (1) | TW200520772A (pt) |
WO (1) | WO2005061712A1 (pt) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
EP2412816B1 (en) | 2004-07-26 | 2014-12-03 | Pfenex Inc. | Process for improved protein expression by strain engineering |
CA2575753A1 (en) * | 2004-09-02 | 2006-03-16 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
US7622445B2 (en) * | 2004-09-02 | 2009-11-24 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
WO2006065582A2 (en) * | 2004-12-14 | 2006-06-22 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
US20080032343A1 (en) | 2005-12-22 | 2008-02-07 | Genentech, Inc. | Recombinant Production of Heparin Binding Proteins |
CA2656835C (en) | 2006-07-14 | 2017-12-19 | Genentech, Inc. | Refolding of recombinant proteins |
AU2008232937B2 (en) | 2007-03-30 | 2012-09-27 | Ambrx, Inc. | Modified FGF-21 polypeptides and their uses |
CA2685326A1 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
EP3260129A1 (en) | 2007-08-03 | 2017-12-27 | Eli Lilly and Company | An fgf-21 compound and a glp-1 compound for use in the treatment of obesity |
US20110015345A1 (en) * | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
AU2016203765B2 (en) * | 2008-10-10 | 2017-04-13 | Amgen Inc. | FGF21 mutants and uses thereof |
CA2739615C (en) | 2008-10-10 | 2017-12-05 | Amgen Inc. | Fgf21 mutants comprising polyethylene glycol and uses thereof |
WO2010065439A1 (en) * | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
BRPI1007313A2 (pt) * | 2009-01-23 | 2016-02-10 | Novo Nordisk As | derivados de fgf21 com ligante de albumina a-b-c-d-e e seu uso. |
CA2760674A1 (en) | 2009-05-05 | 2010-11-11 | Amgen Inc. | Fgf21 mutants and uses thereof |
AU2010246108B2 (en) | 2009-05-05 | 2014-10-23 | Amgen Inc. | FGF21 mutants and uses thereof |
EP2440235A1 (en) * | 2009-06-11 | 2012-04-18 | Novo Nordisk A/S | Glp-1 and fgf21 combinations for treatment of diabetes type 2 |
JP2012530493A (ja) | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
WO2011068893A1 (en) | 2009-12-02 | 2011-06-09 | Amgen Inc. | BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN β-KLOTHO AND BOTH HUMAN FGFR1C AND HUMANβ-KLOTHO |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
EP2460527A1 (en) | 2010-01-21 | 2012-06-06 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
CA2796055A1 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | Human fgf receptor and .beta.-klotho binding proteins |
AU2011239386B2 (en) | 2010-04-16 | 2015-03-19 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using FGF |
WO2012010553A1 (en) | 2010-07-20 | 2012-01-26 | Novo Nordisk A/S | N-terminal modified fgf21 compounds |
AU2011324886A1 (en) | 2010-11-05 | 2013-05-23 | Covx Technologies Ireland Limited | Anti-diabetic compounds |
US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
WO2012121428A1 (ko) * | 2011-03-07 | 2012-09-13 | 주식회사 웰스킨 | 다이펩타이드를 유효성분으로 포함하는 섬유모세포 증식 조성물 및 상기 조성물을 포함하는 제품 |
KR102077721B1 (ko) | 2011-07-01 | 2020-02-14 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사성 장애 및 질환의 치료를 위한 조성물, 용도 및 방법 |
EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
TW201315742A (zh) * | 2011-09-26 | 2013-04-16 | Novartis Ag | 治療代謝病症之雙功能蛋白質 |
UY34346A (es) * | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de fusión para tratar trastornos metabólicos |
AR087973A1 (es) | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
MX2014007626A (es) | 2011-12-22 | 2014-09-16 | Pfizer | Compuestos anti-diabetes. |
WO2013131091A1 (en) | 2012-03-02 | 2013-09-06 | New York University | Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders |
US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
KR20150006059A (ko) | 2012-06-11 | 2015-01-15 | 일라이 릴리 앤드 캄파니 | 섬유모세포 성장 인자 21 변이체 |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
EP2925775B1 (en) | 2012-11-28 | 2020-09-16 | NGM Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
ES2915851T3 (es) | 2012-12-27 | 2022-06-27 | Ngm Biopharmaceuticals Inc | Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares |
WO2014130659A1 (en) | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
WO2015057908A1 (en) | 2013-10-18 | 2015-04-23 | Novartis Ag | Methods of treating diabetes and related disorders |
WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
CN105828833A (zh) | 2013-10-21 | 2016-08-03 | 萨克生物研究学院 | 突变的成纤维细胞生长因子(fgf)1及使用方法 |
CA2927592C (en) | 2013-10-28 | 2020-08-18 | Ngm Biopharmaceuticals, Inc. | Fgf-19 variants for treating a fgf-19 dependent cancer or tumor |
WO2015103782A1 (en) * | 2014-01-13 | 2015-07-16 | Wenzhou Medical College Biological Pharmaceuticals And Nature Products Ltd., Co | Fgf21 mutant and conjugate thereof |
AU2015209131B2 (en) | 2014-01-24 | 2020-06-25 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
WO2015138278A1 (en) | 2014-03-11 | 2015-09-17 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN104311656B (zh) * | 2014-10-14 | 2017-04-05 | 哈尔滨博翱生物医药技术开发有限公司 | cFGF‑21蛋白及其在治疗类风湿关节炎中的应用 |
US10517929B2 (en) | 2014-10-23 | 2019-12-31 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising FGF19 variants |
JP6702962B2 (ja) | 2014-10-24 | 2020-06-03 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 改変fgf−21ポリペプチドおよびその使用 |
WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
EP3236991B1 (en) | 2014-12-23 | 2019-06-19 | Novo Nordisk A/S | Fgf21 derivatives and uses thereof |
US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
EP3368059A4 (en) | 2015-10-30 | 2019-03-27 | Salk Institute for Biological Studies | TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) -1 ANALOGUE |
CA3003616C (en) | 2015-11-09 | 2020-07-28 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
TW201731867A (zh) | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
WO2017220706A1 (en) * | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Pharmaceutical compositions of fgf21 derivatives and uses thereof |
AU2017315459B2 (en) | 2016-08-26 | 2023-06-29 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
JP7181886B2 (ja) | 2017-03-14 | 2022-12-01 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 免疫グロブリンのFc部分を含む二重標的融合タンパク質 |
BR112019023260A2 (pt) | 2017-05-05 | 2022-02-22 | Trefoil Therapeutics, Inc. | Fatores de crescimento de fibroblastos recombinantes modificados e seus usos terapêuticos |
BR112020004136A2 (pt) | 2017-09-08 | 2020-09-08 | Bristol-Myers Squibb Company | fator de crescimento de fibroblastos modificado 21 (fgf-21) para uso nos métodos de tratamento de esteato-hepatite não alcoólica (nash) |
WO2019119673A1 (zh) | 2017-12-19 | 2019-06-27 | 北京吉源生物科技有限公司 | 一种双基因修饰的干细胞及其用途 |
CN110128525B (zh) | 2018-02-08 | 2022-08-26 | 广东东阳光药业有限公司 | Fgf21变体、融合蛋白及其应用 |
EP3817720A2 (en) | 2018-07-03 | 2021-05-12 | Bristol-Myers Squibb Company | Fgf21 formulations |
CN110791517A (zh) * | 2018-08-01 | 2020-02-14 | 中国农业大学 | 成纤维细胞生长因子21的制备、纯化及其结晶 |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
CN111944055B (zh) | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
US20230346957A1 (en) | 2020-01-08 | 2023-11-02 | Bristol-Myers Squibb Company | Fgf-21 conjugate formulations |
WO2021139744A1 (en) | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
BR112022021765A2 (pt) * | 2020-04-29 | 2022-12-13 | Onegene Biotechnology Inc | Conjugado de proteína, composição farmacêutica, método para prevenção ou tratamento de esteato-hepatite não alcoólica, fígado gorduroso, fibrose hepática, cirrose, câncer de fígado, obesidade ou diabetes, método para preparação de um conjugado de proteína |
JP2023538533A (ja) | 2020-08-07 | 2023-09-08 | ブリストル-マイヤーズ スクイブ カンパニー | 線維症の処置のための、ccr2/5拮抗剤と組み合わせたfgf21 |
US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
CN113633756A (zh) * | 2021-06-17 | 2021-11-12 | 温州医科大学 | Fgf21温敏缓释载体和基因修饰方法以及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7408047B1 (en) * | 1999-09-07 | 2008-08-05 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
AU7368100A (en) | 1999-09-10 | 2001-04-10 | Curagen Corporation | Fibroblast growth factor polypeptide and nucleic acids encoding same |
WO2001032678A1 (en) | 1999-11-05 | 2001-05-10 | Smithkline Beecham Corporation | sbgFGF-19a |
US6716626B1 (en) * | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
DE60043197D1 (pt) | 1999-11-18 | 2009-12-03 | Univ Kyoto | |
WO2001049849A1 (en) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf11 |
WO2001072957A2 (en) | 2000-03-31 | 2001-10-04 | Nobuyuki Itoh | Fibroblast growth factor-like molecules and uses thereof |
JP2004515216A (ja) | 2000-06-06 | 2004-05-27 | インサイト・ゲノミックス・インコーポレイテッド | 細胞外メッセンジャー |
US20050048507A1 (en) * | 2001-01-11 | 2005-03-03 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
US20040259780A1 (en) | 2001-07-30 | 2004-12-23 | Glasebrook Andrew Lawrence | Method for treating diabetes and obesity |
CA2468610A1 (en) | 2002-01-15 | 2003-07-24 | Eli Lilly And Company | Method for reducing morbidity and mortality in critically ill patients |
WO2006031696A1 (en) * | 2004-09-13 | 2006-03-23 | Cooper Technologies Company | Fusible switching disconnect modules and devices |
-
2004
- 2004-12-01 WO PCT/US2004/037200 patent/WO2005061712A1/en active Application Filing
- 2004-12-01 CA CA002549249A patent/CA2549249A1/en not_active Abandoned
- 2004-12-01 BR BRPI0416683-3A patent/BRPI0416683A/pt not_active Application Discontinuation
- 2004-12-01 AU AU2004303783A patent/AU2004303783A1/en not_active Abandoned
- 2004-12-01 JP JP2006543822A patent/JP4477013B2/ja not_active Expired - Fee Related
- 2004-12-01 EA EA200601121A patent/EA200601121A1/ru unknown
- 2004-12-01 KR KR1020067011358A patent/KR20060135648A/ko not_active Application Discontinuation
- 2004-12-01 EP EP10184261A patent/EP2270163A1/en not_active Withdrawn
- 2004-12-01 US US10/579,510 patent/US7491697B2/en not_active Expired - Fee Related
- 2004-12-01 CN CNA200480035794XA patent/CN1890371A/zh active Pending
- 2004-12-01 EP EP04810531A patent/EP1702067A1/en not_active Withdrawn
- 2004-12-09 AR ARP040104584A patent/AR046877A1/es unknown
- 2004-12-10 TW TW093138483A patent/TW200520772A/zh unknown
-
2006
- 2006-05-18 IL IL175736A patent/IL175736A0/en unknown
- 2006-06-09 NO NO20062662A patent/NO20062662L/no not_active Application Discontinuation
-
2009
- 2009-01-06 US US12/349,119 patent/US20090118190A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2004303783A1 (en) | 2005-07-07 |
EA200601121A1 (ru) | 2006-10-27 |
US7491697B2 (en) | 2009-02-17 |
CA2549249A1 (en) | 2005-07-07 |
US20090118190A1 (en) | 2009-05-07 |
KR20060135648A (ko) | 2006-12-29 |
EP2270163A1 (en) | 2011-01-05 |
US20070142278A1 (en) | 2007-06-21 |
CN1890371A (zh) | 2007-01-03 |
IL175736A0 (en) | 2008-02-09 |
TW200520772A (en) | 2005-07-01 |
WO2005061712A1 (en) | 2005-07-07 |
JP2007535306A (ja) | 2007-12-06 |
JP4477013B2 (ja) | 2010-06-09 |
EP1702067A1 (en) | 2006-09-20 |
NO20062662L (no) | 2006-08-07 |
AR046877A1 (es) | 2005-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0416683A (pt) | muteìna de fator de crescimento de fibroblasto de humano 21 (fgf-21), ou um seu peptìdeo biologicamente ativo, polinucleotìdeo, vetor de expressão, célula hospedeira, processo para produzir um polipeptìdeo, composição farmacêutica, método para tratar um paciente, e, uso da muteìna fgf-21 | |
CN101796063B (zh) | 使用糖聚乙二醇化g‑csf的治疗方法 | |
CN116115629A (zh) | 核酸产品及其施用方法 | |
BR122013003013B1 (pt) | Proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção | |
RU95113418A (ru) | Полипептиды, способы получения, днк, вектор, клетка, применение полипептида, фармацевтические композиции | |
CN109477102A (zh) | 核酸产品及其施用方法 | |
NO955189L (no) | En forkortet keratinocyt vekstfaktor (KGF) med ökende biologisk aktivitet | |
NO974812L (no) | Nytt protein og fremgangsmåte for fremstilling av dette | |
BR0207576A (pt) | Variante glicosilada de um polipeptìdeo de interferon beta precursor (ifnb), processos de aumentar a glicosilação in vivo de uma molécula de ifnb precursora, de produzir uma molécula de ifnb glicosilada, para preparar uma variante conjugada e de tratar um mamìfero com esclerose múltiplam composição farmacêutica, molécula de ifnb variante, sequência de nucleotìdeo, vetor de expressão, célula hospedeira de glicosilação conjugado, e, uso de um conjugado | |
KR880000463A (ko) | 사슬 결합법 | |
CN106632682A (zh) | 融合蛋白ifn-elp及其应用 | |
PT804479E (pt) | Método para o tratamento de diabetes mellitus utilizando kgf | |
CA2692358A1 (en) | Recombinant human interferon-like proteins | |
CA2202390C (en) | Keratinocyte growth factor analogs | |
MX2022007546A (es) | Interferon-alfa-2 modificado que tiene inmunogenicidad reducida. | |
CN100381462C (zh) | 肽及含有所述肽的药物组合物 | |
KR890700606A (ko) | 생물학적 활성분자 | |
KR890006815A (ko) | 산성 섬유아세포 생장인자의 돌연변이체 | |
JP2008518622A5 (pt) | ||
CN110078793B (zh) | 一种具有抗衰老和修复作用的多肽及其用途 | |
DE60143561D1 (de) | Nukleinsäuren kodierend für polypeptide mit chips aktivität | |
EP4209505A1 (en) | Composition comprising peptide, and use thereof | |
DE59109085D1 (de) | Epididymis-spezifische Polypeptide und deren Verwendung | |
CA2616187A1 (en) | Human growth hormone conjugated with biocompatible polymer | |
RU2004137000A (ru) | Мутеины плацентарного фактора роста 1 типа, способ их получения и применение |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |