AR046877A1 - Muteinas del factor de crecimiento de fibroblastos 21 - Google Patents

Muteinas del factor de crecimiento de fibroblastos 21

Info

Publication number
AR046877A1
AR046877A1 ARP040104584A ARP040104584A AR046877A1 AR 046877 A1 AR046877 A1 AR 046877A1 AR P040104584 A ARP040104584 A AR P040104584A AR P040104584 A ARP040104584 A AR P040104584A AR 046877 A1 AR046877 A1 AR 046877A1
Authority
AR
Argentina
Prior art keywords
muteins
growth factor
fibroblast growth
nucleic acid
species
Prior art date
Application number
ARP040104584A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR046877A1 publication Critical patent/AR046877A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)

Abstract

Se refiere a muteínas del factor de crecimiento de fibroblastos humano 21 con propiedades farmacéuticas mejoradas. Se describen tanto las especies proteicas como las respectivas especies de ácidos nucleicos que las codifican. También incluye vectores y células huésped para la propagación de dichas secuencias de ácidos nucleicos y la producción de dichas muteínas. También se describen procedimientos para tratar la diabetes de tipo 2, la obesidad, el síndrome metabólico y para reducir la mortalidad y la morbilidad de los pacientes gravemente enfermos.
ARP040104584A 2003-12-10 2004-12-09 Muteinas del factor de crecimiento de fibroblastos 21 AR046877A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52858203P 2003-12-10 2003-12-10

Publications (1)

Publication Number Publication Date
AR046877A1 true AR046877A1 (es) 2005-12-28

Family

ID=34710086

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104584A AR046877A1 (es) 2003-12-10 2004-12-09 Muteinas del factor de crecimiento de fibroblastos 21

Country Status (14)

Country Link
US (2) US7491697B2 (es)
EP (2) EP1702067A1 (es)
JP (1) JP4477013B2 (es)
KR (1) KR20060135648A (es)
CN (1) CN1890371A (es)
AR (1) AR046877A1 (es)
AU (1) AU2004303783A1 (es)
BR (1) BRPI0416683A (es)
CA (1) CA2549249A1 (es)
EA (1) EA200601121A1 (es)
IL (1) IL175736A0 (es)
NO (1) NO20062662L (es)
TW (1) TW200520772A (es)
WO (1) WO2005061712A1 (es)

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US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
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EP2161281A1 (en) * 2004-09-02 2010-03-10 Eli Lilly & Company Muteins of fibroblast growth factor 21
US7622445B2 (en) * 2004-09-02 2009-11-24 Eli Lilly And Company Muteins of fibroblast growth factor 21
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Also Published As

Publication number Publication date
TW200520772A (en) 2005-07-01
US7491697B2 (en) 2009-02-17
WO2005061712A1 (en) 2005-07-07
NO20062662L (no) 2006-08-07
CA2549249A1 (en) 2005-07-07
IL175736A0 (en) 2008-02-09
JP4477013B2 (ja) 2010-06-09
CN1890371A (zh) 2007-01-03
EP1702067A1 (en) 2006-09-20
US20070142278A1 (en) 2007-06-21
EP2270163A1 (en) 2011-01-05
KR20060135648A (ko) 2006-12-29
BRPI0416683A (pt) 2007-01-30
AU2004303783A1 (en) 2005-07-07
US20090118190A1 (en) 2009-05-07
JP2007535306A (ja) 2007-12-06
EA200601121A1 (ru) 2006-10-27

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