BRPI0416255A - proteìnas de ligação a il-18 - Google Patents
proteìnas de ligação a il-18Info
- Publication number
- BRPI0416255A BRPI0416255A BRPI0416255-2A BRPI0416255A BRPI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A
- Authority
- BR
- Brazil
- Prior art keywords
- hil
- antibodies
- activity
- antibody
- binding proteins
- Prior art date
Links
- 102000044166 interleukin-18 binding protein Human genes 0.000 title abstract 2
- 108010070145 interleukin-18 binding protein Proteins 0.000 title abstract 2
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 abstract 7
- 102000043959 human IL18 Human genes 0.000 abstract 7
- 230000000694 effects Effects 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C07K2317/71—Decreased effector function due to an Fc-modification
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
"PROTEìNAS DE LIGAçãO A IL-18". A presente invenção abrange proteínas que se ligam a IL-18, especialmente anticorpos que se ligam a interleucina-18 humana (hIL-18). Mais especificamente a invenção se refere a anticorpos que são anticorpos inteiramente humanos. Os anticorpos preferidos têm uma grande afinidade para hIL18 e/ou neutralizam a atividade de hIL-18 in vitro e in vivo. Um anticorpo da invenção pode ser um anticorpo de comprimento total ou uma porção sua que se liga a antígeno. São também propostos o método de produção e o método de utilização dos anticorpos da invenção. Os anticorpos ou porções de anticorpos da invenção são úteis para a detecção de hIL-18 e para a inibição da atividade de hIL-18, em um paciente humano, por exemplo, que esteja afetado por um distúrbio no qual a atividade de hIL-18 é prejudicial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/706,689 US20050100965A1 (en) | 2003-11-12 | 2003-11-12 | IL-18 binding proteins |
PCT/US2004/037971 WO2005047307A2 (en) | 2003-11-12 | 2004-11-12 | Il-18 binding proteins |
Publications (1)
Publication Number | Publication Date |
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BRPI0416255A true BRPI0416255A (pt) | 2007-01-09 |
Family
ID=34552597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI0416255-2A BRPI0416255A (pt) | 2003-11-12 | 2004-11-12 | proteìnas de ligação a il-18 |
Country Status (20)
Country | Link |
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US (1) | US20050100965A1 (pt) |
EP (5) | EP1685152B1 (pt) |
JP (4) | JP5054977B2 (pt) |
KR (4) | KR101282320B1 (pt) |
CN (4) | CN101979412A (pt) |
AT (1) | ATE555130T1 (pt) |
AU (1) | AU2004290073B2 (pt) |
BR (1) | BRPI0416255A (pt) |
CA (2) | CA2805859A1 (pt) |
CY (1) | CY1112893T1 (pt) |
DK (1) | DK1685152T3 (pt) |
ES (1) | ES2385484T3 (pt) |
HK (1) | HK1098762A1 (pt) |
IL (2) | IL175422A0 (pt) |
NZ (2) | NZ593068A (pt) |
PL (1) | PL1685152T3 (pt) |
PT (1) | PT1685152E (pt) |
SI (1) | SI1685152T1 (pt) |
WO (1) | WO2005047307A2 (pt) |
ZA (1) | ZA200603733B (pt) |
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2003
- 2003-11-12 US US10/706,689 patent/US20050100965A1/en not_active Abandoned
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2004
- 2004-11-12 JP JP2006539948A patent/JP5054977B2/ja not_active Expired - Fee Related
- 2004-11-12 CA CA2805859A patent/CA2805859A1/en not_active Abandoned
- 2004-11-12 KR KR1020127001647A patent/KR101282320B1/ko not_active IP Right Cessation
- 2004-11-12 CN CN201010274020XA patent/CN101979412A/zh active Pending
- 2004-11-12 AT AT04817825T patent/ATE555130T1/de active
- 2004-11-12 EP EP04817825A patent/EP1685152B1/en not_active Not-in-force
- 2004-11-12 EP EP11173631A patent/EP2460830A3/en not_active Withdrawn
- 2004-11-12 CN CN2010102739861A patent/CN101948539B/zh not_active Expired - Fee Related
- 2004-11-12 ES ES04817825T patent/ES2385484T3/es active Active
- 2004-11-12 WO PCT/US2004/037971 patent/WO2005047307A2/en active Application Filing
- 2004-11-12 NZ NZ593068A patent/NZ593068A/xx not_active IP Right Cessation
- 2004-11-12 PL PL04817825T patent/PL1685152T3/pl unknown
- 2004-11-12 EP EP11173615A patent/EP2460829A3/en not_active Withdrawn
- 2004-11-12 EP EP11173650A patent/EP2395020A3/en not_active Withdrawn
- 2004-11-12 KR KR1020127031335A patent/KR20130006525A/ko not_active Application Discontinuation
- 2004-11-12 CN CN2004800399482A patent/CN1902229B/zh not_active Expired - Fee Related
- 2004-11-12 PT PT04817825T patent/PT1685152E/pt unknown
- 2004-11-12 KR KR1020127028781A patent/KR20120136416A/ko not_active Application Discontinuation
- 2004-11-12 BR BRPI0416255-2A patent/BRPI0416255A/pt not_active IP Right Cessation
- 2004-11-12 KR KR1020067009221A patent/KR20060123148A/ko not_active Application Discontinuation
- 2004-11-12 SI SI200431865T patent/SI1685152T1/sl unknown
- 2004-11-12 CN CN2012101293119A patent/CN102659944A/zh active Pending
- 2004-11-12 AU AU2004290073A patent/AU2004290073B2/en not_active Ceased
- 2004-11-12 EP EP11173595A patent/EP2385070A1/en not_active Withdrawn
- 2004-11-12 NZ NZ582097A patent/NZ582097A/en not_active IP Right Cessation
- 2004-11-12 DK DK04817825.5T patent/DK1685152T3/da active
- 2004-11-12 CA CA002543920A patent/CA2543920A1/en not_active Abandoned
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2006
- 2006-05-04 IL IL175422A patent/IL175422A0/en unknown
- 2006-05-10 ZA ZA200603733A patent/ZA200603733B/en unknown
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2007
- 2007-01-30 HK HK07101057.1A patent/HK1098762A1/xx not_active IP Right Cessation
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2010
- 2010-07-13 IL IL206979A patent/IL206979A0/en unknown
- 2010-12-16 JP JP2010280298A patent/JP2011097946A/ja active Pending
- 2010-12-16 JP JP2010280299A patent/JP2011097947A/ja active Pending
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2012
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