BRPI0416255A - proteìnas de ligação a il-18 - Google Patents

proteìnas de ligação a il-18

Info

Publication number
BRPI0416255A
BRPI0416255A BRPI0416255-2A BRPI0416255A BRPI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A BR PI0416255 A BRPI0416255 A BR PI0416255A
Authority
BR
Brazil
Prior art keywords
hil
antibodies
activity
antibody
binding proteins
Prior art date
Application number
BRPI0416255-2A
Other languages
English (en)
Inventor
Tariq Ghayur
Boris Labkovsky
Jeffrey W Voss
Larry Green
John Babcook
Xiao-Chi Jia
James Wieler
Jaspal Singh Kang
Brad Hedberg
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BRPI0416255A publication Critical patent/BRPI0416255A/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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Abstract

"PROTEìNAS DE LIGAçãO A IL-18". A presente invenção abrange proteínas que se ligam a IL-18, especialmente anticorpos que se ligam a interleucina-18 humana (hIL-18). Mais especificamente a invenção se refere a anticorpos que são anticorpos inteiramente humanos. Os anticorpos preferidos têm uma grande afinidade para hIL18 e/ou neutralizam a atividade de hIL-18 in vitro e in vivo. Um anticorpo da invenção pode ser um anticorpo de comprimento total ou uma porção sua que se liga a antígeno. São também propostos o método de produção e o método de utilização dos anticorpos da invenção. Os anticorpos ou porções de anticorpos da invenção são úteis para a detecção de hIL-18 e para a inibição da atividade de hIL-18, em um paciente humano, por exemplo, que esteja afetado por um distúrbio no qual a atividade de hIL-18 é prejudicial.
BRPI0416255-2A 2003-11-12 2004-11-12 proteìnas de ligação a il-18 BRPI0416255A (pt)

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US10/706,689 US20050100965A1 (en) 2003-11-12 2003-11-12 IL-18 binding proteins
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ATE555130T1 (de) 2012-05-15
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