BR9916999A - Heterociclos de 2-arilimino substituìdos ecomposições contendo-os, para uso como agentesde ligação do receptor de progesterona - Google Patents

Heterociclos de 2-arilimino substituìdos ecomposições contendo-os, para uso como agentesde ligação do receptor de progesterona

Info

Publication number
BR9916999A
BR9916999A BR9916999-1A BR9916999A BR9916999A BR 9916999 A BR9916999 A BR 9916999A BR 9916999 A BR9916999 A BR 9916999A BR 9916999 A BR9916999 A BR 9916999A
Authority
BR
Brazil
Prior art keywords
arylimino
heterocycles
substituted
compositions containing
progesterone receptor
Prior art date
Application number
BR9916999-1A
Other languages
English (en)
Inventor
Brian R Dixon
Cedo M Bagi
Catherine R Brennan
David R Brittelli
William H Bullock
Jinshan Chen
William L Collibee
Obert Dally
Jeffrey S Johnson
Harold C E Kluender
William F Lathrop
Peiying Liu
Carol Ann Mase
Aniko M Redmann
Williamj Scott
Klaus Urbahns
Donald J Wolanin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR9916999A publication Critical patent/BR9916999A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Patente de Invenção: "HETEROCICLOS DE 2-ARILIMINOSUBSTITUìDOS E COMPOSIçõES CONTENDO-OS, PARA USOCOMO AGENTES DE LiGAçãO DO RECEPTOR DEPROGESTERONA". Esta invenção refere-se a heterociclos de2-arilimino, incluindo2-arilimino-1,3-tiazolidinas,2-arilimino-2,3,4,5-tetraidro-1,3-tiazinas,2-arilimino-1,3-tiazolidin-4-onas, 2-arilimino-1,3-tiazolidin-5-onas e2-arilimino-1,3-oxazolidinas, e seu uso na modulação dos processosmediados pelo receptor da progesterona, e composiçõesfarmacêuticas para uso em tais terapias.
BR9916999-1A 1999-01-14 1999-12-14 Heterociclos de 2-arilimino substituìdos ecomposições contendo-os, para uso como agentesde ligação do receptor de progesterona BR9916999A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14
PCT/US1999/029601 WO2000042031A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Publications (1)

Publication Number Publication Date
BR9916999A true BR9916999A (pt) 2001-10-30

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916999-1A BR9916999A (pt) 1999-01-14 1999-12-14 Heterociclos de 2-arilimino substituìdos ecomposições contendo-os, para uso como agentesde ligação do receptor de progesterona

Country Status (21)

Country Link
EP (1) EP1144396A2 (pt)
JP (1) JP2002534517A (pt)
KR (1) KR20010089831A (pt)
CN (1) CN1337955A (pt)
AR (1) AR022214A1 (pt)
AU (1) AU2708700A (pt)
BG (1) BG105761A (pt)
BR (1) BR9916999A (pt)
CA (1) CA2359562A1 (pt)
CO (1) CO5160338A1 (pt)
CZ (1) CZ20012530A3 (pt)
GT (1) GT200000003A (pt)
HU (1) HUP0105134A2 (pt)
ID (1) ID30514A (pt)
IL (1) IL144031A0 (pt)
NO (1) NO20013318L (pt)
SK (1) SK10032001A3 (pt)
SV (1) SV2002000005A (pt)
TR (1) TR200102041T2 (pt)
WO (1) WO2000042031A2 (pt)
ZA (1) ZA200105253B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2383659C (en) * 1999-08-31 2009-02-10 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
RO122179B1 (ro) * 1999-08-31 2009-02-27 Schering Aktiengesellschaft Utilizarea de mezoprogestine pentru tratamentul şi prevenirea afecţiunilor ginecologice benigne, hormon-dependente
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
ATE393150T1 (de) * 1999-09-14 2008-05-15 Shionogi & Co 2-imino-1,3-thiazin-derivate
WO2001072723A1 (fr) * 2000-03-28 2001-10-04 Nippon Soda Co.,Ltd. Derived d'oxa(thia)zolidine et medicament anti-inflammatoire
CN1395467A (zh) * 2000-09-07 2003-02-05 美国拜尔公司 用作孕酮受体结合剂的环和非环脒以及包含它们的药物组合物
JP4188694B2 (ja) * 2001-03-08 2008-11-26 塩野義製薬株式会社 １，３−チアジン誘導体を含有する医薬組成物
JPWO2003000668A1 (ja) 2001-06-25 2004-10-07 日本曹達株式会社 オキサ（チア）ゾリジン化合物、製造法および抗炎症薬
WO2003060078A2 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Heterocyclic modulators of nuclear receptors
JP2007505164A (ja) * 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション アンドロゲン、グルココルチコイド、ミネラルコルチコイドおよびプロゲステロン受容体のモジュレーターとしての１−アミノナフタレン類
CN103382158B (zh) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 一种2-环戊基氨基乙醇的制备方法
US20220251053A1 (en) * 2019-07-10 2022-08-11 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones
CN114507143A (zh) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 一种2-乙基-1-氟-4-硝基苯的合成方法
CN114671828B (zh) * 2022-04-28 2024-05-31 蔚林新材料科技股份有限公司 一种3-甲基-2-噻唑硫酮的制备方法
CN114957288B (zh) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 一种盐酸四咪唑的合成方法
CN115925559A (zh) * 2022-11-11 2023-04-07 上海泰坦科技股份有限公司 一种1-氨基-1-环戊基甲醇的制备方法

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Also Published As

Publication number Publication date
KR20010089831A (ko) 2001-10-08
NO20013318D0 (no) 2001-07-04
WO2000042031A2 (en) 2000-07-20
AU2708700A (en) 2000-08-01
HUP0105134A2 (hu) 2002-04-29
BG105761A (en) 2002-03-29
CO5160338A1 (es) 2002-05-30
SK10032001A3 (sk) 2002-05-09
CN1337955A (zh) 2002-02-27
EP1144396A2 (en) 2001-10-17
NO20013318L (no) 2001-08-30
SV2002000005A (es) 2002-07-16
AR022214A1 (es) 2002-09-04
TR200102041T2 (tr) 2001-12-21
IL144031A0 (en) 2002-04-21
CA2359562A1 (en) 2000-07-20
ID30514A (id) 2001-12-13
CZ20012530A3 (cs) 2002-02-13
ZA200105253B (en) 2002-09-05
JP2002534517A (ja) 2002-10-15
WO2000042031A3 (en) 2000-11-09
GT200000003A (es) 2001-07-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.