BR9910074A - Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas - Google Patents
Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicasInfo
- Publication number
- BR9910074A BR9910074A BR9910074-6A BR9910074A BR9910074A BR 9910074 A BR9910074 A BR 9910074A BR 9910074 A BR9910074 A BR 9910074A BR 9910074 A BR9910074 A BR 9910074A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- group
- oxocyclic
- oxocyclic urea
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA FABRICAçãO DE URéIAS 1,3-DI-SUBSTITUìDAS-4-OXOCìCLICAS"<D>. é revelado um processo para preparar uréias 1,3-di-substituídas-4-oxocíclicas da fórmula geral (I): em que R~ 1~, R~ 2~, e R~ 3~ são selecionados de modo independente entre o grupo consistindo em nada, Cl, F, Br, NH~ 2~, NO~ 2~, COOH, CH~ 3~SO~ 2~ NH, SO~ 3~H, OH, alcóxi, alquila, alcoxicarbonila, hidroxialquila, carboxialquila, e acilóxi; R~ 4~ é selecionado entre o grupo consistindo em um alquila, alquenila, alquinila, alquilacila, e heteroalquila substituído ou não-substituído; e A é um grupo alquil ou alquenil amino substituído ou não-substituído, saturado ou insaturado, de cadeia simples ou ramificada, consistindo em 1 - 7 átomos de carbono; ou A é um heterociclo substituído ou não-substituído, saturado ou insaturado tendo 5, 6, ou 7 membros contendo no mínimo um nitrogênio, e R~ 4~ é anexado a este nitrogênio; em que a uréia 1,3-di-substituída-4-oxocíclica referida é preparada sem isolamento de intermediários e compreendendo as etapas: (Ia) reação de uma uréia 1-substituída-4-oxocíclica com uma cadeia de carbono contendo no mínimo dois grupos de partida na presença de uma base branda e um solvente para formar um aduto contendo no mínimo um grupo de partida, e (Ib) condensação do aduto com uma amina para formar uma uréia 1,3-di-substituída-4-oxocíclica, e (II) recuperação da uréia 1,3-di-substituída-4-oxocíclica referida. Este método é particularmente preferencial para preparar 1-[[[5-(4-clorofenil)-2-furanil]metileno]amino]-3-[4-(4-metil-1-piperazinil )butil)-2,4-imidazolidinadiona.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8349398P | 1998-04-29 | 1998-04-29 | |
| PCT/US1999/009092 WO1999055700A1 (en) | 1998-04-29 | 1999-04-27 | Process for making 1,3-disubstituted-4-oxocyclic ureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910074A true BR9910074A (pt) | 2000-12-26 |
Family
ID=22178700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910074-6A BR9910074A (pt) | 1998-04-29 | 1999-04-27 | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6414151B1 (pt) |
| EP (1) | EP1075473B1 (pt) |
| JP (1) | JP4549531B2 (pt) |
| KR (1) | KR100400050B1 (pt) |
| CN (1) | CN1298403A (pt) |
| AR (1) | AR015044A1 (pt) |
| AT (1) | ATE366251T1 (pt) |
| AU (1) | AU751681B2 (pt) |
| BR (1) | BR9910074A (pt) |
| CA (1) | CA2330686C (pt) |
| CO (1) | CO5070625A1 (pt) |
| CZ (1) | CZ299163B6 (pt) |
| DE (1) | DE69936449T2 (pt) |
| DK (1) | DK1075473T3 (pt) |
| ES (1) | ES2288020T3 (pt) |
| HU (1) | HUP0102666A3 (pt) |
| ID (1) | ID27452A (pt) |
| IL (1) | IL138404A (pt) |
| MY (1) | MY133753A (pt) |
| NO (1) | NO20005424D0 (pt) |
| PE (1) | PE20000925A1 (pt) |
| PL (1) | PL197776B1 (pt) |
| RU (1) | RU2194706C2 (pt) |
| SG (1) | SG120901A1 (pt) |
| SK (1) | SK15842000A3 (pt) |
| TR (1) | TR200003137T2 (pt) |
| WO (1) | WO1999055700A1 (pt) |
| ZA (1) | ZA200004712B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0101356A3 (en) * | 1998-04-29 | 2003-08-28 | Procter & Gamble | Process for making 1,3-disubstituted-4-oxocyclic ureas |
| CN100443473C (zh) * | 2005-04-30 | 2008-12-17 | 中国药科大学 | 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法 |
| US20120178762A1 (en) | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| TW200840578A (en) * | 2006-12-15 | 2008-10-16 | Procter & Gamble | Compositions of azimilide dihydrochloride |
| CN101735203B (zh) * | 2009-12-17 | 2012-05-23 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅱ及其制备方法和用途 |
| CN101735202B (zh) * | 2009-12-17 | 2012-05-30 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅰ及其制备方法和用途 |
| CN101735205B (zh) * | 2009-12-17 | 2013-05-15 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅴ及其制备方法和用途 |
| US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919231A (en) | 1974-06-17 | 1975-11-11 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3906010A (en) | 1974-06-17 | 1975-09-16 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3946049A (en) | 1975-04-03 | 1976-03-23 | Morton-Norwich Products, Inc. | 5-phenyl-2-furamidoximes |
| US4001222A (en) | 1975-10-14 | 1977-01-04 | Morton-Norwich Products, Inc. | 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof |
| JPS5726653A (en) | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| IL82856A0 (en) | 1986-06-26 | 1987-12-20 | Norwich Eaton Pharma | Pharmaceutical compositions containing 2-(5-phenyl-2-furanyl)imidazoles and certain such novel compounds |
| US4882354A (en) | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| JP3031973B2 (ja) * | 1990-08-16 | 2000-04-10 | 富士レビオ株式会社 | フェニトイン誘導体 |
| PL171280B1 (pl) | 1991-08-14 | 1997-03-28 | Procter & Gamble Pharma | Sposób wytwarzania nowych cyklicznych uretanów PL PL |
| HU221317B1 (en) * | 1991-08-14 | 2002-09-28 | Procter & Gamble Pharma | 2,4-imidazolidinedione derivatives and antiarrhythmic and antifibrillatory compositions containing them, and process for producing them |
| HUP0101356A3 (en) * | 1998-04-29 | 2003-08-28 | Procter & Gamble | Process for making 1,3-disubstituted-4-oxocyclic ureas |
-
1999
- 1999-04-27 BR BR9910074-6A patent/BR9910074A/pt not_active IP Right Cessation
- 1999-04-27 DE DE69936449T patent/DE69936449T2/de not_active Expired - Lifetime
- 1999-04-27 PL PL343734A patent/PL197776B1/pl not_active IP Right Cessation
- 1999-04-27 EP EP99917668A patent/EP1075473B1/en not_active Expired - Lifetime
- 1999-04-27 US US09/674,231 patent/US6414151B1/en not_active Expired - Lifetime
- 1999-04-27 WO PCT/US1999/009092 patent/WO1999055700A1/en active IP Right Grant
- 1999-04-27 CN CN99805366A patent/CN1298403A/zh active Pending
- 1999-04-27 TR TR2000/03137T patent/TR200003137T2/xx unknown
- 1999-04-27 DK DK99917668T patent/DK1075473T3/da active
- 1999-04-27 RU RU2000129803/04A patent/RU2194706C2/ru not_active IP Right Cessation
- 1999-04-27 HU HU0102666A patent/HUP0102666A3/hu unknown
- 1999-04-27 ID IDW20002481A patent/ID27452A/id unknown
- 1999-04-27 AU AU35735/99A patent/AU751681B2/en not_active Ceased
- 1999-04-27 SK SK1584-2000A patent/SK15842000A3/sk unknown
- 1999-04-27 AT AT99917668T patent/ATE366251T1/de active
- 1999-04-27 JP JP2000545860A patent/JP4549531B2/ja not_active Expired - Fee Related
- 1999-04-27 CZ CZ20003951A patent/CZ299163B6/cs not_active IP Right Cessation
- 1999-04-27 KR KR10-2000-7011921A patent/KR100400050B1/ko not_active IP Right Cessation
- 1999-04-27 SG SG200207219A patent/SG120901A1/en unknown
- 1999-04-27 IL IL13840499A patent/IL138404A/en not_active IP Right Cessation
- 1999-04-27 ES ES99917668T patent/ES2288020T3/es not_active Expired - Lifetime
- 1999-04-27 CA CA002330686A patent/CA2330686C/en not_active Expired - Fee Related
- 1999-04-29 MY MYPI99001687A patent/MY133753A/en unknown
- 1999-04-29 PE PE1999000353A patent/PE20000925A1/es not_active Application Discontinuation
- 1999-04-29 CO CO99025954A patent/CO5070625A1/es unknown
- 1999-04-29 AR ARP990101996A patent/AR015044A1/es not_active Application Discontinuation
-
2000
- 2000-09-07 ZA ZA200004712A patent/ZA200004712B/en unknown
- 2000-10-27 NO NO20005424A patent/NO20005424D0/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |