BR9607677A - Variantes de porteinase k tendo adsorção reduzida e hidrolise aumentada - Google Patents
Variantes de porteinase k tendo adsorção reduzida e hidrolise aumentadaInfo
- Publication number
- BR9607677A BR9607677A BR9607677A BR9607677A BR9607677A BR 9607677 A BR9607677 A BR 9607677A BR 9607677 A BR9607677 A BR 9607677A BR 9607677 A BR9607677 A BR 9607677A BR 9607677 A BR9607677 A BR 9607677A
- Authority
- BR
- Brazil
- Prior art keywords
- porteinase
- variants
- increased hydrolysis
- reduced adsorption
- adsorption
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
- C11D17/0073—Tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
- C11D17/0069—Laundry bars
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
- C11D17/0073—Tablets
- C11D17/0078—Multilayered tablets
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0052—Gas evolving or heat producing compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40157495A | 1995-03-09 | 1995-03-09 | |
PCT/US1996/003005 WO1996028556A2 (en) | 1995-03-09 | 1996-03-06 | Proteinase k variants having decreased adsorption and increased hydrolysis |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9607677A true BR9607677A (pt) | 1998-07-07 |
Family
ID=23588288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9607677A BR9607677A (pt) | 1995-03-09 | 1996-03-06 | Variantes de porteinase k tendo adsorção reduzida e hidrolise aumentada |
Country Status (14)
Country | Link |
---|---|
US (1) | US6451574B1 (pt) |
EP (1) | EP0813601A2 (pt) |
JP (1) | JPH11501814A (pt) |
CN (1) | CN1183809A (pt) |
AU (1) | AU5092796A (pt) |
BR (1) | BR9607677A (pt) |
CA (1) | CA2214395C (pt) |
CZ (1) | CZ279997A3 (pt) |
HU (1) | HUP9801638A3 (pt) |
IL (1) | IL117350A0 (pt) |
MA (1) | MA23820A1 (pt) |
MX (1) | MX9706841A (pt) |
WO (1) | WO1996028556A2 (pt) |
ZA (1) | ZA961820B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10204500A (ja) * | 1997-01-20 | 1998-08-04 | Soft Kyukyu Corp:Kk | 発泡錠剤洗浄剤 |
ES2368718T3 (es) | 1997-10-23 | 2011-11-21 | Danisco Us Inc. | Variantes de subtilisina con múltiples sustituciones. |
MA25044A1 (fr) * | 1997-10-23 | 2000-10-01 | Procter & Gamble | Compositions de lavage contenant des variants de proteases multisubstituees. |
EP1045892A1 (en) * | 1997-12-22 | 2000-10-25 | The Procter & Gamble Company | Cleaning compositions containing a neopullulanase |
AU2001254623A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Production and use of protein variants having modified immunogenicity |
US6803222B2 (en) * | 2000-11-22 | 2004-10-12 | Kao Corporation | Alkaline proteases |
DE10105911A1 (de) | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Expression der rekombinanten Proteinase K aus Tritirachium album in Hefe |
DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
US7888093B2 (en) | 2002-11-06 | 2011-02-15 | Novozymes A/S | Subtilase variants |
DE10260903A1 (de) * | 2002-12-20 | 2004-07-08 | Henkel Kgaa | Neue Perhydrolasen |
US7294499B2 (en) * | 2003-01-30 | 2007-11-13 | Novozymes A/S | Subtilases |
US7153666B2 (en) | 2003-07-17 | 2006-12-26 | General Atomics | Methods and compositions for determination of glycated proteins |
US7943385B2 (en) | 2006-07-25 | 2011-05-17 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
WO2008013874A1 (en) | 2006-07-25 | 2008-01-31 | General Atomics | Methods for assaying percentage of glycated hemoglobin |
CN102076867A (zh) * | 2008-05-13 | 2011-05-25 | 通用原子公司 | 用于直接测定糖化血红蛋白百分比的电化学生物传感器 |
CN105193640B (zh) * | 2014-06-24 | 2018-10-12 | 金普诺安蛋白质工程技术(北京)有限公司 | 蛋白酶k在皮肤保健和化妆品领域中的应用 |
CN108603187A (zh) * | 2015-11-24 | 2018-09-28 | 诺维信公司 | 具有蛋白酶活性的多肽以及编码它们的多核苷酸 |
CN109207460B (zh) * | 2018-10-23 | 2021-06-15 | 大连博格林生物科技有限公司 | 重组布氏白僵菌蛋白酶k突变体pk-m2及制备方法 |
CN109280656B (zh) * | 2018-10-23 | 2021-06-15 | 大连博格林生物科技有限公司 | 重组布氏白僵菌蛋白酶k突变体pk-m1及制备方法 |
US20200199565A1 (en) * | 2018-12-20 | 2020-06-25 | New England Biolabs, Inc. | Proteinases with Improved Properties |
CN112592931A (zh) * | 2020-12-31 | 2021-04-02 | 安徽丰原发酵技术工程研究有限公司 | 一种生产重组蛋白酶k的方法 |
CN113913412B (zh) * | 2021-10-13 | 2023-10-03 | 湖北大学 | 蛋白酶k突变体及其制备方法 |
CN114196656B (zh) * | 2021-12-29 | 2023-10-24 | 南京巨匠生物科技有限公司 | 一种蛋白酶k突变体及其表达载体的构建和应用 |
CN115775591B (zh) * | 2023-01-10 | 2023-06-09 | 华测检测认证集团股份有限公司 | 一种引物设计方法、装置、设备及可读存储介质 |
Family Cites Families (59)
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US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US5310675A (en) * | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
NZ208612A (en) * | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
US5972682A (en) * | 1984-05-29 | 1999-10-26 | Genencor International, Inc. | Enzymatically active modified subtilisins |
US5346823A (en) * | 1984-05-29 | 1994-09-13 | Genencor, Inc. | Subtilisin modifications to enhance oxidative stability |
US5371008A (en) * | 1984-05-29 | 1994-12-06 | Genencor International, Inc. | Substrate assisted catalysis |
US5244791A (en) * | 1984-05-29 | 1993-09-14 | Genecor International, Inc. | Methods of ester hydrolysis |
US5185258A (en) * | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
US5700676A (en) * | 1984-05-29 | 1997-12-23 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
US5155033A (en) * | 1989-01-06 | 1992-10-13 | Genencor, Inc. | Subtilisins modified at position 225 resulting in a shift in catalytic activity |
US5371190A (en) * | 1984-05-29 | 1994-12-06 | Genencor International, Inc. | Substrate assisted catalysis |
US5182204A (en) * | 1984-05-29 | 1993-01-26 | Genencor International, Inc. | Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors |
WO1987004461A1 (en) | 1986-01-15 | 1987-07-30 | Amgen | THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS AND METHOD FOR PRODUCTION THEREOF |
US4908773A (en) | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
US5013657A (en) | 1988-04-12 | 1991-05-07 | Bryan Philip N | Subtilisin mutations |
US4990452A (en) * | 1986-02-12 | 1991-02-05 | Genex Corporation | Combining mutations for stabilization of subtilisin |
US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
JPS63502959A (ja) | 1986-02-12 | 1988-11-02 | ジェネックス、コ−ポレ−ション | 突然変異誘発及びスクリ−ニング方法並びに生成物 |
US5240632A (en) * | 1986-03-26 | 1993-08-31 | Amway Corporation | Machine dishwasher water spot control composition |
IE65767B1 (en) * | 1986-04-30 | 1995-11-15 | Genencor Int | Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors |
NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
JP3026567B2 (ja) * | 1987-02-27 | 2000-03-27 | ジェネンコー インターナショナル インコーポレイテッド | 分子のクローニング及びタンパク分解酵素をコードする遺伝子の発現 |
ATE184316T1 (de) * | 1987-04-06 | 1999-09-15 | Novo Nordisk As | Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen |
US5260207A (en) * | 1987-04-06 | 1993-11-09 | Enzon Labs Inc. | Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins |
US4914031A (en) * | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
CN1056187C (zh) * | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
US5324653A (en) * | 1988-02-11 | 1994-06-28 | Gist-Brocades N.V. | Recombinant genetic means for the production of serine protease muteins |
US6287841B1 (en) * | 1988-02-11 | 2001-09-11 | Genencor International, Inc. | High alkaline serine protease |
US5116741A (en) | 1988-04-12 | 1992-05-26 | Genex Corporation | Biosynthetic uses of thermostable proteases |
US5246849A (en) | 1988-04-12 | 1993-09-21 | Enzon, Inc. | Thermally stable serine proteases |
US5118623A (en) * | 1988-05-27 | 1992-06-02 | Solvay Enzymes, Inc. | Bleach stable enzymes |
WO1990014420A1 (en) * | 1989-05-17 | 1990-11-29 | Amgen Inc. | Multiply mutated subtilisins |
JPH04500384A (ja) | 1989-06-26 | 1992-01-23 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 酵素洗剤組成物 |
EP0405901B1 (en) * | 1989-06-26 | 2004-09-01 | Unilever Plc | Enzymatic detergent compositions |
US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
DK316989D0 (da) | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
US5352603A (en) * | 1989-08-31 | 1994-10-04 | Kali-Chemie Ag | Highly alkaline proteases |
US6271012B1 (en) * | 1989-10-11 | 2001-08-07 | Genencor International, Inc. | Protease muteins and their use in detergents |
DE4009534A1 (de) * | 1990-03-24 | 1991-09-26 | Henkel Kgaa | Fluessiges handreinigungsmittel |
DK97190D0 (da) * | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
US5629173A (en) * | 1990-08-09 | 1997-05-13 | Genentech, Inc. | Methods of use of serine protease variants having peptide ligase activity |
WO1992002615A1 (en) * | 1990-08-09 | 1992-02-20 | Genentech, Inc. | Serine protease variants having peptide ligase activity |
DK271490D0 (da) * | 1990-11-14 | 1990-11-14 | Novo Nordisk As | Detergentkomposition |
US5482849A (en) * | 1990-12-21 | 1996-01-09 | Novo Nordisk A/S | Subtilisin mutants |
ES2110488T3 (es) | 1990-12-21 | 1998-02-16 | Novo Nordisk As | Mutantes enzimaticos con un bajo grado de variacion de la carga molecular en un intervalo de ph. |
US5340735A (en) * | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
EP0995801A1 (de) * | 1991-07-27 | 2000-04-26 | Genencor International GmbH | Verfahren zur Verbesserung des Stabilität von Enzymen und stabilisierte Enzyme |
US5275945A (en) * | 1991-10-08 | 1994-01-04 | Vista Chemical Company | Alkaline proteases stable in heavy-duty detergent liquids |
PL178045B1 (pl) * | 1992-07-17 | 2000-02-29 | Genencor Int | Mutant proteazy do stosowania w detergentach, sekwencja DNA kodująca mutanta proteazy, sposób otrzymywania mutanta proteazy oraz kompozycja detergentowa |
US5567601A (en) * | 1993-06-01 | 1996-10-22 | University Of Maryland | Subtilisin mutants lacking a primary calcium binding site |
US5470733A (en) * | 1993-06-01 | 1995-11-28 | University Of Maryland | Calcium free subtilisin mutants |
WO1995007991A2 (en) | 1993-09-15 | 1995-03-23 | The Procter & Gamble Company | Subtilisin bpn' variants with decreased adsorption and increased hydrolysis |
US6436690B1 (en) * | 1993-09-15 | 2002-08-20 | The Procter & Gamble Company | BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
DE69432954T2 (de) * | 1993-10-14 | 2004-04-22 | The Procter & Gamble Company, Cincinnati | Proteasen enthaltende bleichmittelzusammensetzungen |
AU8079794A (en) * | 1993-10-14 | 1995-05-04 | Procter & Gamble Company, The | Protease-containing cleaning compositions |
ES2364774T3 (es) * | 1994-02-24 | 2011-09-14 | HENKEL AG & CO. KGAA | Enzimas mejoradas y detergentes que las contienen. |
US6599730B1 (en) * | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
US5780285A (en) * | 1995-03-03 | 1998-07-14 | Genentech, Inc. | Subtilisin variants capable of cleaving substrates containing dibasic residues |
-
1996
- 1996-03-04 IL IL11735096A patent/IL117350A0/xx unknown
- 1996-03-06 CA CA002214395A patent/CA2214395C/en not_active Expired - Fee Related
- 1996-03-06 EP EP96907182A patent/EP0813601A2/en not_active Withdrawn
- 1996-03-06 JP JP8527690A patent/JPH11501814A/ja active Pending
- 1996-03-06 ZA ZA961820A patent/ZA961820B/xx unknown
- 1996-03-06 CZ CZ972799A patent/CZ279997A3/cs unknown
- 1996-03-06 MX MX9706841A patent/MX9706841A/es unknown
- 1996-03-06 AU AU50927/96A patent/AU5092796A/en not_active Abandoned
- 1996-03-06 BR BR9607677A patent/BR9607677A/pt not_active Application Discontinuation
- 1996-03-06 WO PCT/US1996/003005 patent/WO1996028556A2/en not_active Application Discontinuation
- 1996-03-06 HU HU9801638A patent/HUP9801638A3/hu unknown
- 1996-03-06 CN CN96193792A patent/CN1183809A/zh active Pending
- 1996-03-07 MA MA24177A patent/MA23820A1/fr unknown
-
1997
- 1997-09-23 US US08/935,887 patent/US6451574B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUP9801638A2 (hu) | 1998-10-28 |
IL117350A0 (en) | 1996-07-23 |
MX9706841A (es) | 1997-11-29 |
WO1996028556A3 (en) | 1997-07-17 |
MA23820A1 (fr) | 1996-10-01 |
HUP9801638A3 (en) | 2001-01-29 |
ZA961820B (en) | 1996-09-10 |
CZ279997A3 (cs) | 1998-01-14 |
AU5092796A (en) | 1996-10-02 |
EP0813601A2 (en) | 1997-12-29 |
US6451574B1 (en) | 2002-09-17 |
WO1996028556A2 (en) | 1996-09-19 |
CA2214395C (en) | 2001-10-30 |
CA2214395A1 (en) | 1996-09-19 |
CN1183809A (zh) | 1998-06-03 |
JPH11501814A (ja) | 1999-02-16 |
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