BR112022001359A2 - Método e composição para anticorpos anti-cd73 e variantes - Google Patents
Método e composição para anticorpos anti-cd73 e variantesInfo
- Publication number
- BR112022001359A2 BR112022001359A2 BR112022001359A BR112022001359A BR112022001359A2 BR 112022001359 A2 BR112022001359 A2 BR 112022001359A2 BR 112022001359 A BR112022001359 A BR 112022001359A BR 112022001359 A BR112022001359 A BR 112022001359A BR 112022001359 A2 BR112022001359 A2 BR 112022001359A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- variants
- antigen
- binding fragments
- composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
método e composição para anticorpos anti-cd73 e variantes. trata-se de anticorpos anti-cd73, variantes e fragmentos de ligação ao antígeno dos mesmos. os anticorpos, as variantes e os fragmentos de ligação ao antígeno dos mesmos se ligam a cd73 humano com alta afinidade e suprimem a atividade enzimática de cd73 e, opcionalmente, induzem a internalização de cd73. são adicionalmente fornecidas moléculas de ácido nucleico isoladas que codificam os anticorpos anti-cd73, as variantes e os fragmentos de ligação ao antígeno dos mesmos, e um vetor de expressão relacionado e uma célula hospedeira. é fornecido um método para a preparação dos anticorpos anti-cd73, das variantes e dos fragmentos de ligação ao antígeno dos mesmos. são adicionalmente fornecidas composições farmacêuticas relacionadas e um método para uso das ditas composições farmacêuticas no tratamento de um indivíduo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910683287.5A CN112300279A (zh) | 2019-07-26 | 2019-07-26 | 针对抗cd73抗体和变体的方法和组合物 |
PCT/CN2020/102678 WO2021017892A1 (zh) | 2019-07-26 | 2020-07-17 | 针对抗cd73抗体和变体的方法和组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022001359A2 true BR112022001359A2 (pt) | 2022-05-24 |
Family
ID=74230130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022001359A BR112022001359A2 (pt) | 2019-07-26 | 2020-07-17 | Método e composição para anticorpos anti-cd73 e variantes |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220162334A1 (pt) |
EP (1) | EP4006054A4 (pt) |
JP (1) | JP2022542165A (pt) |
CN (2) | CN112300279A (pt) |
BR (1) | BR112022001359A2 (pt) |
CA (1) | CA3145897A1 (pt) |
WO (1) | WO2021017892A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022179039A1 (zh) * | 2021-02-24 | 2022-09-01 | 苏州近岸蛋白质科技股份有限公司 | 抗人cd73抗体及其应用 |
GB202105110D0 (en) * | 2021-04-09 | 2021-05-26 | Cancer Research Tech Ltd | Anti-CD73 antibodies |
WO2022247826A1 (zh) * | 2021-05-28 | 2022-12-01 | 和铂医药(上海)有限责任公司 | 靶向pd-l1和cd73的特异性结合蛋白 |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
CN116178546A (zh) * | 2022-10-13 | 2023-05-30 | 深圳市百士通科技开发有限公司 | 一种多功能重组抗体及其制备方法和应用 |
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BR112019011988A2 (pt) * | 2016-12-13 | 2019-11-05 | Astellas Pharma Inc | anticorpo anti-cd73 humana |
AU2018213549B2 (en) * | 2017-01-24 | 2022-02-03 | I-Mab Biopharma Co., Ltd. | Anti-CD73 antibodies and uses thereof |
CN110753703B (zh) * | 2017-05-23 | 2024-04-09 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 新的cd73抗体、其制备和用途 |
CR20190593A (es) * | 2017-06-22 | 2020-05-10 | Novartis Ag | Moléculas de anticuerpo que se unen a cd73 y usos de las mismas |
EP3642240A1 (en) * | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
-
2019
- 2019-07-26 CN CN201910683287.5A patent/CN112300279A/zh not_active Withdrawn
-
2020
- 2020-07-17 JP JP2022505389A patent/JP2022542165A/ja active Pending
- 2020-07-17 EP EP20847134.2A patent/EP4006054A4/en active Pending
- 2020-07-17 CA CA3145897A patent/CA3145897A1/en active Pending
- 2020-07-17 CN CN202080053981.XA patent/CN114206930A/zh active Pending
- 2020-07-17 BR BR112022001359A patent/BR112022001359A2/pt unknown
- 2020-07-17 WO PCT/CN2020/102678 patent/WO2021017892A1/zh unknown
-
2022
- 2022-01-25 US US17/584,258 patent/US20220162334A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4006054A4 (en) | 2023-11-29 |
CA3145897A1 (en) | 2021-02-04 |
EP4006054A1 (en) | 2022-06-01 |
US20220162334A1 (en) | 2022-05-26 |
CN114206930A (zh) | 2022-03-18 |
WO2021017892A1 (zh) | 2021-02-04 |
JP2022542165A (ja) | 2022-09-29 |
CN112300279A (zh) | 2021-02-02 |
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