BR112021018947A2 - Compostos macrocíclicos como agonistas de sting - Google Patents
Compostos macrocíclicos como agonistas de stingInfo
- Publication number
- BR112021018947A2 BR112021018947A2 BR112021018947A BR112021018947A BR112021018947A2 BR 112021018947 A2 BR112021018947 A2 BR 112021018947A2 BR 112021018947 A BR112021018947 A BR 112021018947A BR 112021018947 A BR112021018947 A BR 112021018947A BR 112021018947 A2 BR112021018947 A2 BR 112021018947A2
- Authority
- BR
- Brazil
- Prior art keywords
- macrocyclic compounds
- sting agonists
- compounds
- disclosed
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Abstract
compostos macrocíclicos como agonistas de sting. são divulgados os compostos macrocíclicos de fórmula geral (i) e suas formas tautoméricas, estereoisômeros, sais farmaceuticamente aceitáveis e combinação dos mesmos com medicamentos adequados, processos correspondentes para a síntese e composições farmacêuticas e usos dos compostos aqui divulgados.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201921012258 | 2019-03-28 | ||
| IN201921046194 | 2019-11-13 | ||
| PCT/IB2020/052654 WO2020194160A1 (en) | 2019-03-28 | 2020-03-21 | Macrocyclic compounds as sting agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021018947A2 true BR112021018947A2 (pt) | 2022-02-08 |
Family
ID=70293003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021018947A BR112021018947A2 (pt) | 2019-03-28 | 2020-03-21 | Compostos macrocíclicos como agonistas de sting |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20220144852A1 (pt) |
| EP (1) | EP3946610A1 (pt) |
| JP (1) | JP2022527306A (pt) |
| KR (1) | KR20210146370A (pt) |
| CN (1) | CN113631228B (pt) |
| AU (1) | AU2020245263A1 (pt) |
| BR (1) | BR112021018947A2 (pt) |
| CA (1) | CA3132508A1 (pt) |
| CL (1) | CL2021002480A1 (pt) |
| CO (1) | CO2021012559A2 (pt) |
| CR (1) | CR20210495A (pt) |
| EC (1) | ECSP21071644A (pt) |
| IL (1) | IL286526A (pt) |
| MA (1) | MA55517A (pt) |
| MX (1) | MX2021011686A (pt) |
| PE (1) | PE20220169A1 (pt) |
| SG (1) | SG11202109191SA (pt) |
| WO (1) | WO2020194160A1 (pt) |
| ZA (1) | ZA202106629B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3147397A1 (en) * | 2019-07-22 | 2021-01-28 | Lupin Limited | Macrocyclic compounds as sting agonists and methods and uses thereof |
| JP2022543086A (ja) | 2019-08-02 | 2022-10-07 | メルサナ セラピューティクス インコーポレイテッド | がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物 |
| EP4134098A4 (en) | 2020-04-10 | 2024-05-15 | Ono Pharmaceutical Co | CANCER THERAPY METHODS |
| JP2024503508A (ja) * | 2021-01-15 | 2024-01-25 | シージェン インコーポレイテッド | 免疫調節性抗体－薬物コンジュゲート |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104513253A (zh) * | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| JP6835727B2 (ja) * | 2015-02-05 | 2021-02-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｉｒａｋ１／４阻害剤としての大環状化合物及びその使用 |
| CA3030582A1 (en) | 2015-07-22 | 2017-01-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Compounds and uses thereof in the treatment of cancers and other medical conditions |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| CR20200045A (es) * | 2016-04-07 | 2020-03-11 | Glaxosmithkline Ip Dev Ltd | AMIDAS HETEROCÍCLICAS ÚTILES COMO MODULADORES DE PROTEÍNAS (Divisional 2018-0472) |
| EP3440072B1 (en) | 2016-04-07 | 2020-01-29 | GlaxoSmithKline Intellectual Property Development Ltd | Heterocyclic amides useful as protein modulators |
| US20200138827A1 (en) | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| UA125730C2 (uk) | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
| JP2020524718A (ja) | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | ヒトｓｔｉｎｇの複素環式小分子調節因子 |
| EP3658138B1 (en) | 2017-07-27 | 2023-04-19 | Stingray Therapeutics, Inc. | Substituted-3h-imidazo(4,5-c)pyridine and 1h-pyrrolo(2,3-c)pyridine series of novel ectonucleotide pyrophsphatase/phosphodiestrase-1 (enpp1) and stimulator for interferon genes (sting) modulator as cancer immunotherapeutics |
| AU2018311965A1 (en) * | 2017-08-04 | 2020-02-13 | Merck Sharp & Dohme Llc | Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment |
| MA49772A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Agonistes benzo[b]thiophène de sting pour le traitement du cancer |
-
2020
- 2020-03-21 PE PE2021001577A patent/PE20220169A1/es unknown
- 2020-03-21 MA MA055517A patent/MA55517A/fr unknown
- 2020-03-21 KR KR1020217035108A patent/KR20210146370A/ko unknown
- 2020-03-21 WO PCT/IB2020/052654 patent/WO2020194160A1/en active Application Filing
- 2020-03-21 CN CN202080025785.1A patent/CN113631228B/zh active Active
- 2020-03-21 US US17/598,524 patent/US20220144852A1/en active Pending
- 2020-03-21 EP EP20719719.5A patent/EP3946610A1/en active Pending
- 2020-03-21 MX MX2021011686A patent/MX2021011686A/es unknown
- 2020-03-21 JP JP2021557830A patent/JP2022527306A/ja active Pending
- 2020-03-21 BR BR112021018947A patent/BR112021018947A2/pt unknown
- 2020-03-21 CR CR20210495A patent/CR20210495A/es unknown
- 2020-03-21 CA CA3132508A patent/CA3132508A1/en active Pending
- 2020-03-21 SG SG11202109191SA patent/SG11202109191SA/en unknown
- 2020-03-21 AU AU2020245263A patent/AU2020245263A1/en active Pending
-
2021
- 2021-09-08 ZA ZA2021/06629A patent/ZA202106629B/en unknown
- 2021-09-19 IL IL286526A patent/IL286526A/en unknown
- 2021-09-24 EC ECSENADI202171644A patent/ECSP21071644A/es unknown
- 2021-09-24 CL CL2021002480A patent/CL2021002480A1/es unknown
- 2021-09-24 CO CONC2021/0012559A patent/CO2021012559A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220144852A1 (en) | 2022-05-12 |
| ZA202106629B (en) | 2022-07-27 |
| CA3132508A1 (en) | 2020-10-01 |
| CO2021012559A2 (es) | 2021-09-30 |
| PE20220169A1 (es) | 2022-01-28 |
| IL286526A (en) | 2021-10-31 |
| WO2020194160A1 (en) | 2020-10-01 |
| AU2020245263A1 (en) | 2021-10-07 |
| JP2022527306A (ja) | 2022-06-01 |
| KR20210146370A (ko) | 2021-12-03 |
| CR20210495A (es) | 2021-10-18 |
| SG11202109191SA (en) | 2021-09-29 |
| CN113631228B (zh) | 2023-10-13 |
| CL2021002480A1 (es) | 2022-04-29 |
| CN113631228A (zh) | 2021-11-09 |
| MX2021011686A (es) | 2021-10-22 |
| MA55517A (fr) | 2022-02-09 |
| EP3946610A1 (en) | 2022-02-09 |
| ECSP21071644A (es) | 2021-12-30 |
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