ECSP21071644A - Compuestos macrocíclicos como agonistas de sting - Google Patents

Compuestos macrocíclicos como agonistas de sting

Info

Publication number
ECSP21071644A
ECSP21071644A ECSENADI202171644A ECDI202171644A ECSP21071644A EC SP21071644 A ECSP21071644 A EC SP21071644A EC SENADI202171644 A ECSENADI202171644 A EC SENADI202171644A EC DI202171644 A ECDI202171644 A EC DI202171644A EC SP21071644 A ECSP21071644 A EC SP21071644A
Authority
EC
Ecuador
Prior art keywords
macrocyclic compounds
sting agonists
compounds
disclosed
macrocyclic
Prior art date
Application number
ECSENADI202171644A
Other languages
English (en)
Inventor
Moloy Banerjee
Vinod Vyavahare
Vidya Ramdas
Vaibhav Kalhapure
Navnath Karche
Pradeep Patil
Venkata Palle
Deepak Walke
Rajender Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of ECSP21071644A publication Critical patent/ECSP21071644A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Abstract

Se desvelan compuestos macrocíclicos que tienen la Fórmula general (I) y sus formas tautoméricas, estereoisómeros, sales farmacéuticamente aceptables y su combinación con un medicamento adecuado, procesos correspondientes para la síntesis, y composiciones farmacéuticas y usos de compuestos desvelados en el presente documento.
ECSENADI202171644A 2019-03-28 2021-09-24 Compuestos macrocíclicos como agonistas de sting ECSP21071644A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201921012258 2019-03-28
IN201921046194 2019-11-13

Publications (1)

Publication Number Publication Date
ECSP21071644A true ECSP21071644A (es) 2021-12-30

Family

ID=70293003

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202171644A ECSP21071644A (es) 2019-03-28 2021-09-24 Compuestos macrocíclicos como agonistas de sting

Country Status (19)

Country Link
US (1) US20220144852A1 (es)
EP (1) EP3946610A1 (es)
JP (1) JP2022527306A (es)
KR (1) KR20210146370A (es)
CN (1) CN113631228B (es)
AU (1) AU2020245263A1 (es)
BR (1) BR112021018947A2 (es)
CA (1) CA3132508A1 (es)
CL (1) CL2021002480A1 (es)
CO (1) CO2021012559A2 (es)
CR (1) CR20210495A (es)
EC (1) ECSP21071644A (es)
IL (1) IL286526A (es)
MA (1) MA55517A (es)
MX (1) MX2021011686A (es)
PE (1) PE20220169A1 (es)
SG (1) SG11202109191SA (es)
WO (1) WO2020194160A1 (es)
ZA (1) ZA202106629B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3147397A1 (en) * 2019-07-22 2021-01-28 Lupin Limited Macrocyclic compounds as sting agonists and methods and uses thereof
JP2022543086A (ja) 2019-08-02 2022-10-07 メルサナ セラピューティクス インコーポレイテッド がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物
EP4134098A4 (en) 2020-04-10 2024-05-15 Ono Pharmaceutical Co CANCER THERAPY METHODS
JP2024503508A (ja) * 2021-01-15 2024-01-25 シージェン インコーポレイテッド 免疫調節性抗体－薬物コンジュゲート

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104513253A (zh) * 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
JP6835727B2 (ja) * 2015-02-05 2021-02-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｒａｋ１／４阻害剤としての大環状化合物及びその使用
CA3030582A1 (en) 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
AR107032A1 (es) 2015-12-09 2018-03-14 Padlock Therapeutics Inc Inhibidores bicíclicos de pad4
CR20200045A (es) * 2016-04-07 2020-03-11 Glaxosmithkline Ip Dev Ltd AMIDAS HETEROCÍCLICAS ÚTILES COMO MODULADORES DE PROTEÍNAS (Divisional 2018-0472)
EP3440072B1 (en) 2016-04-07 2020-01-29 GlaxoSmithKline Intellectual Property Development Ltd Heterocyclic amides useful as protein modulators
US20200138827A1 (en) 2017-06-22 2020-05-07 Curadev Pharma Limited Small molecule modulators of human sting
UA125730C2 (uk) 2017-06-22 2022-05-25 Курадев Фарма Лімітед Низькомолекулярні модулятори sting людини
JP2020524718A (ja) 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ ヒトｓｔｉｎｇの複素環式小分子調節因子
EP3658138B1 (en) 2017-07-27 2023-04-19 Stingray Therapeutics, Inc. Substituted-3h-imidazo(4,5-c)pyridine and 1h-pyrrolo(2,3-c)pyridine series of novel ectonucleotide pyrophsphatase/phosphodiestrase-1 (enpp1) and stimulator for interferon genes (sting) modulator as cancer immunotherapeutics
AU2018311965A1 (en) * 2017-08-04 2020-02-13 Merck Sharp & Dohme Llc Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment
MA49772A (fr) 2017-08-04 2021-04-21 Merck Sharp & Dohme Agonistes benzo[b]thiophène de sting pour le traitement du cancer

Also Published As

Publication number Publication date
US20220144852A1 (en) 2022-05-12
ZA202106629B (en) 2022-07-27
CA3132508A1 (en) 2020-10-01
CO2021012559A2 (es) 2021-09-30
PE20220169A1 (es) 2022-01-28
IL286526A (en) 2021-10-31
WO2020194160A1 (en) 2020-10-01
AU2020245263A1 (en) 2021-10-07
JP2022527306A (ja) 2022-06-01
KR20210146370A (ko) 2021-12-03
CR20210495A (es) 2021-10-18
SG11202109191SA (en) 2021-09-29
CN113631228B (zh) 2023-10-13
CL2021002480A1 (es) 2022-04-29
CN113631228A (zh) 2021-11-09
MX2021011686A (es) 2021-10-22
MA55517A (fr) 2022-02-09
BR112021018947A2 (pt) 2022-02-08
EP3946610A1 (en) 2022-02-09

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