CL2019002745A1 - Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue. - Google Patents

Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue.

Info

Publication number
CL2019002745A1
CL2019002745A1 CL2019002745A CL2019002745A CL2019002745A1 CL 2019002745 A1 CL2019002745 A1 CL 2019002745A1 CL 2019002745 A CL2019002745 A CL 2019002745A CL 2019002745 A CL2019002745 A CL 2019002745A CL 2019002745 A1 CL2019002745 A1 CL 2019002745A1
Authority
CL
Chile
Prior art keywords
compounds
dengue virus
refers
virus replication
replication inhibitors
Prior art date
Application number
CL2019002745A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Bart Rudolf Romanie Kesteleyn
Jean-François Bonfanti
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Erwin Coesemans
Original Assignee
Univ Leuven Kath
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath, Janssen Pharmaceuticals Inc filed Critical Univ Leuven Kath
Publication of CL2019002745A1 publication Critical patent/CL2019002745A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A DERIVADOS DE INDOLINA SUSTITUIDOS, A MÉTODOS PARA PREVENIR O TRATAR INFECCIONES VIRALES POR DENGUE MEDIANTE EL USO DE DICHOS COMPUESTOS Y TAMBIÉN SE REFIERE A DICHOS COMPUESTOS PARA SU USO COMO MEDICAMENTO, MÁS PREFERENTEMENTE, PARA SU USO COMO MEDICAMENTO PARA TRATAR O PREVENIR INFECCIONES VIRALES POR DENGUE. LA PRESENTE INVENCIÓN SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS O PREPARADOS COMBINADOS DE LOS COMPUESTOS, A LAS COMPOSICIONES O PREPARADOS PARA SU USO COMO UN MEDICAMENTO, MÁS PREFERENTEMENTE PARA LA PREVENCIÓN O EL TRATAMIENTO DE INFECCIONES VIRALES POR DENGUE. LA INVENCIÓN TAMBIÉN SE REFIERE A PROCESOS PARA LA PREPARACIÓN DE LOS COMPUESTOS.
CL2019002745A 2017-03-31 2019-09-26 Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue. CL2019002745A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164048 2017-03-31

Publications (1)

Publication Number Publication Date
CL2019002745A1 true CL2019002745A1 (es) 2019-12-27

Family

ID=58464340

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019002745A CL2019002745A1 (es) 2017-03-31 2019-09-26 Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue.

Country Status (32)

Country Link
US (1) US11083707B2 (es)
EP (1) EP3601266B1 (es)
JP (1) JP7203752B2 (es)
KR (1) KR102530832B1 (es)
CN (1) CN110461831B (es)
AR (1) AR111314A1 (es)
AU (1) AU2018246301B2 (es)
BR (1) BR112019020175A2 (es)
CA (1) CA3055867C (es)
CL (1) CL2019002745A1 (es)
CO (1) CO2019010295A2 (es)
CR (1) CR20190446A (es)
DK (1) DK3601266T3 (es)
EA (1) EA039784B1 (es)
EC (1) ECSP19070369A (es)
ES (1) ES2884151T3 (es)
HR (1) HRP20210942T1 (es)
HU (1) HUE054678T2 (es)
IL (1) IL269658B (es)
JO (1) JOP20180025B1 (es)
LT (1) LT3601266T (es)
MX (1) MX2019011606A (es)
NI (1) NI201900099A (es)
PE (1) PE20191650A1 (es)
PH (1) PH12019502201A1 (es)
SG (1) SG11201908786VA (es)
SI (1) SI3601266T1 (es)
TW (1) TWI795393B (es)
UA (1) UA126288C2 (es)
UY (1) UY37645A (es)
WO (1) WO2018178240A1 (es)
ZA (1) ZA201906395B (es)

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Also Published As

Publication number Publication date
PH12019502201A1 (en) 2020-09-28
ZA201906395B (en) 2021-05-26
ES2884151T3 (es) 2021-12-10
AR111314A1 (es) 2019-06-26
EP3601266B1 (en) 2021-04-28
UA126288C2 (uk) 2022-09-14
SG11201908786VA (en) 2019-10-30
CA3055867C (en) 2024-01-02
CN110461831A (zh) 2019-11-15
ECSP19070369A (es) 2019-10-31
SI3601266T1 (sl) 2021-08-31
TW201900635A (zh) 2019-01-01
CA3055867A1 (en) 2018-10-04
KR102530832B1 (ko) 2023-05-09
US20200121647A1 (en) 2020-04-23
HUE054678T2 (hu) 2021-09-28
UY37645A (es) 2018-09-28
PE20191650A1 (es) 2019-11-07
CR20190446A (es) 2019-11-29
MX2019011606A (es) 2019-11-08
NI201900099A (es) 2020-03-11
JOP20180025A1 (ar) 2019-01-30
DK3601266T3 (da) 2021-07-19
EA039784B1 (ru) 2022-03-14
AU2018246301A1 (en) 2019-09-19
CN110461831B (zh) 2022-11-01
EP3601266A1 (en) 2020-02-05
AU2018246301B2 (en) 2021-08-19
HRP20210942T1 (hr) 2021-10-15
BR112019020175A2 (pt) 2020-06-02
LT3601266T (lt) 2021-07-12
JP7203752B2 (ja) 2023-01-13
JP2020512355A (ja) 2020-04-23
WO2018178240A1 (en) 2018-10-04
US11083707B2 (en) 2021-08-10
TWI795393B (zh) 2023-03-11
IL269658A (en) 2019-11-28
CO2019010295A2 (es) 2019-10-09
JOP20180025B1 (ar) 2021-08-17
KR20190137108A (ko) 2019-12-10
EA201992329A1 (ru) 2020-02-20
IL269658B (en) 2022-01-01

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