BR112019000213A2 - processo para preparar derivados de piridina halogenados - Google Patents

processo para preparar derivados de piridina halogenados

Info

Publication number
BR112019000213A2
BR112019000213A2 BR112019000213-8A BR112019000213A BR112019000213A2 BR 112019000213 A2 BR112019000213 A2 BR 112019000213A2 BR 112019000213 A BR112019000213 A BR 112019000213A BR 112019000213 A2 BR112019000213 A2 BR 112019000213A2
Authority
BR
Brazil
Prior art keywords
pyridine derivatives
halogenated pyridine
preparing halogenated
formula
halogen
Prior art date
Application number
BR112019000213-8A
Other languages
English (en)
Other versions
BR112019000213B1 (pt
Inventor
Mosrin Marc
Fischer Rüdiger
Hager Dominik
Hoffmeister Laura
Kausch-Busies Nina
Wilcke David
Willot Matthieu
Original Assignee
Bayer Cropscience Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Aktiengesellschaft filed Critical Bayer Cropscience Aktiengesellschaft
Publication of BR112019000213A2 publication Critical patent/BR112019000213A2/pt
Publication of BR112019000213B1 publication Critical patent/BR112019000213B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06—Zinc compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation

Abstract

a presente invenção se refere a um processo para preparar derivados de piridina halogenados da fórmula (ii) procedentes de compostos da fórmula (i) através de intermediários da fórmula (iiia) ou (iiib) (i) (ii) (iii) (iiib), em que os radicais q e w são, cada um, independentemente halogênio, r2 é halogênio ou ?o-pivaloíla, e y é halogênio, co2r1 ou no2, em que r1 é (c1-c6)-alquila ou (c1-c6)-haloalquila.
BR112019000213-8A 2016-07-05 2017-06-28 Derivados de piridina halogenados, seu processo de preparação e seus intermediários BR112019000213B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16178022.6 2016-07-05
EP16178022 2016-07-05
PCT/EP2017/065989 WO2018007224A1 (de) 2016-07-05 2017-06-28 Verfahren zur herstellung halogenierter pyridinderivate

Publications (2)

Publication Number Publication Date
BR112019000213A2 true BR112019000213A2 (pt) 2019-04-16
BR112019000213B1 BR112019000213B1 (pt) 2022-10-25

Family

ID=56363777

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019000213-8A BR112019000213B1 (pt) 2016-07-05 2017-06-28 Derivados de piridina halogenados, seu processo de preparação e seus intermediários

Country Status (15)

Country Link
US (1) US10766909B2 (pt)
EP (1) EP3481805B1 (pt)
JP (1) JP7034953B2 (pt)
KR (1) KR102408111B1 (pt)
CN (1) CN109476601B (pt)
AR (1) AR108943A1 (pt)
BR (1) BR112019000213B1 (pt)
DK (1) DK3481805T3 (pt)
ES (1) ES2941903T3 (pt)
FI (1) FI3481805T3 (pt)
IL (1) IL263970B (pt)
MX (1) MX2019000254A (pt)
TW (1) TWI766872B (pt)
UY (1) UY37315A (pt)
WO (1) WO2018007224A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI820231B (zh) 2018-10-11 2023-11-01 德商拜耳廠股份有限公司 用於製備經取代咪唑衍生物之方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947457A (en) 1974-12-27 1976-03-30 The Dow Chemical Company Method for preparing 2,5-dihalo- and 2,5,6-trihalopyridines
US8569337B2 (en) * 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
WO2012052948A1 (en) * 2010-10-20 2012-04-26 Pfizer Inc. Pyridine- 2- derivatives as smoothened receptor modulators
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors

Also Published As

Publication number Publication date
KR102408111B1 (ko) 2022-06-10
BR112019000213B1 (pt) 2022-10-25
TWI766872B (zh) 2022-06-11
WO2018007224A1 (de) 2018-01-11
US10766909B2 (en) 2020-09-08
JP2019521123A (ja) 2019-07-25
EP3481805B1 (de) 2023-01-18
UY37315A (es) 2018-01-31
KR20190025626A (ko) 2019-03-11
ES2941903T3 (es) 2023-05-26
TW201811747A (zh) 2018-04-01
MX2019000254A (es) 2019-05-27
CN109476601B (zh) 2022-10-28
DK3481805T3 (da) 2023-04-11
CN109476601A (zh) 2019-03-15
FI3481805T3 (fi) 2023-04-25
JP7034953B2 (ja) 2022-03-14
AR108943A1 (es) 2018-10-10
IL263970B (en) 2021-06-30
US20190330241A1 (en) 2019-10-31
IL263970A (en) 2019-01-31
EP3481805A1 (de) 2019-05-15

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/06/2017, OBSERVADAS AS CONDICOES LEGAIS