BR112019000015A2 - distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticos - Google Patents
distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticosInfo
- Publication number
- BR112019000015A2 BR112019000015A2 BR112019000015-1A BR112019000015A BR112019000015A2 BR 112019000015 A2 BR112019000015 A2 BR 112019000015A2 BR 112019000015 A BR112019000015 A BR 112019000015A BR 112019000015 A2 BR112019000015 A2 BR 112019000015A2
- Authority
- BR
- Brazil
- Prior art keywords
- pseudotyped oncolytic
- oncolytic virus
- therapeutic polypeptides
- virus delivery
- oncolytic viruses
- Prior art date
Links
- 244000309459 oncolytic virus Species 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K35/66—Microorganisms or materials therefrom
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- A61K35/66—Microorganisms or materials therefrom
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- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- C—CHEMISTRY; METALLURGY
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C—CHEMISTRY; METALLURGY
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- C07K14/52—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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Abstract
são descritos neste documento vírus oncolíticos pseudotipados que compreendem ácidos nucleicos que codificam uma molécula acopladora (engager). em algumas modalidades, os vírus oncolíticos pseudotipados compreendem ácidos nucleicos que codificam uma molécula acopladora e uma ou mais moléculas terapêuticas. são fornecidas ainda neste documento composições farmacêuticas contendo vírus oncolíticos pseudotipados e métodos de tratamento de câncer usando os vírus oncolíticos pseudotipados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662357195P | 2016-06-30 | 2016-06-30 | |
US62/357,195 | 2016-06-30 | ||
PCT/US2017/040354 WO2018006005A1 (en) | 2016-06-30 | 2017-06-30 | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
Publications (1)
Publication Number | Publication Date |
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BR112019000015A2 true BR112019000015A2 (pt) | 2019-04-24 |
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CN109983121A (zh) | 2019-07-05 |
RU2758007C2 (ru) | 2021-10-25 |
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US20190048082A1 (en) | 2019-02-14 |
AU2017290828A1 (en) | 2019-01-24 |
RU2019102391A3 (pt) | 2021-01-26 |
IL282216A (en) | 2021-05-31 |
JP2022048304A (ja) | 2022-03-25 |
KR20190035714A (ko) | 2019-04-03 |
JP2019519245A (ja) | 2019-07-11 |
IL263879A (en) | 2019-01-31 |
IL263879B (en) | 2021-04-29 |
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