BR112017025954A2 - apresentação em superfície de antígenos em vesículas de membrana externa gram-negativa - Google Patents

apresentação em superfície de antígenos em vesículas de membrana externa gram-negativa

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Publication number
BR112017025954A2
BR112017025954A2 BR112017025954-0A BR112017025954A BR112017025954A2 BR 112017025954 A2 BR112017025954 A2 BR 112017025954A2 BR 112017025954 A BR112017025954 A BR 112017025954A BR 112017025954 A2 BR112017025954 A2 BR 112017025954A2
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BR
Brazil
Prior art keywords
gram
outer membrane
membrane vesicles
fusion
antigens
Prior art date
Application number
BR112017025954-0A
Other languages
English (en)
Inventor
Louis Marten Salverda Merijn
André Van Der Ley Peter
Original Assignee
De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport filed Critical De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport
Publication of BR112017025954A2 publication Critical patent/BR112017025954A2/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
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    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

a presente invenção refere-se a composições de vacinas baseadas em vesículas de membrana externa gram-negativas que exibem antígenos de patógenos expressos como parte de uma proteína de fusão compreendendo partes n-terminais de lipoproteínas expressas na superfície de bactérias gram-negativas, e uso de tais composições na vacinação. a invenção refere-se ainda às lipoproteínas de fusão compreendendo partes n-terminais de lipoproteínas expressas em superfície de bactérias gram-negativas e antígenos de agentes de patógenos fundidos a elas, construtos de dna e células hospedeiras bacterianas para expressar estas lipoproteínas de fusão e métodos para a produção de vesículas de membrana externa que apresentam as lipoproteínas de fusão.
BR112017025954-0A 2015-06-02 2016-06-02 apresentação em superfície de antígenos em vesículas de membrana externa gram-negativa BR112017025954A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EM15170307.1 2015-06-02
EP15170307 2015-06-02
PCT/EP2016/062494 WO2016193370A1 (en) 2015-06-02 2016-06-02 Surface display of antigens on gram-negative outer membrane vesicles

Publications (1)

Publication Number Publication Date
BR112017025954A2 true BR112017025954A2 (pt) 2018-08-14

Family

ID=53365837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025954-0A BR112017025954A2 (pt) 2015-06-02 2016-06-02 apresentação em superfície de antígenos em vesículas de membrana externa gram-negativa

Country Status (10)

Country Link
US (2) US10639280B2 (pt)
EP (1) EP3302511A1 (pt)
JP (1) JP7008900B2 (pt)
CN (2) CN117247460A (pt)
AU (1) AU2016269722B2 (pt)
BR (1) BR112017025954A2 (pt)
CA (1) CA2987306A1 (pt)
HK (1) HK1253310A1 (pt)
MX (1) MX2017015404A (pt)
WO (1) WO2016193370A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3720945A1 (en) 2017-12-04 2020-10-14 De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzjin en Sport An improved process for producing outer membrane vesicles
KR20200142028A (ko) * 2018-04-10 2020-12-21 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 애주번트로서의 버크홀데리아 슈도말레이 복합체 외막 소포체
WO2020046982A1 (en) * 2018-08-27 2020-03-05 University Of Virginia Patent Foundation Compositions and methods for preventing and treating virus infection
CN111358942A (zh) * 2018-12-25 2020-07-03 国家纳米科学中心 一种疫苗及其制备方法
JP7462864B2 (ja) * 2019-04-19 2024-04-08 国立感染症研究所長 メンブレンヴェシクル
CN111018998B (zh) * 2019-12-04 2021-10-29 杭州傲锐生物医药科技有限公司 一种莱姆重组融合蛋白OspC-VlsE及其应用
JP2023525294A (ja) * 2020-05-08 2023-06-15 イントラヴァック ベスローテン フェノーツハップ クリックｏｍｖ
WO2022011014A1 (en) * 2020-07-09 2022-01-13 Exocure Biosciences, Inc. Bacteria-derived vesicles and use thereof for generating immune response to sars-cov-2
US20220160856A1 (en) * 2020-11-25 2022-05-26 Lankenau Institute For Medical Research Methods and compositions for the diagnosis, prophylaxis and treatment of lyme disease

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US5777095A (en) * 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
AU8640501A (en) 2000-07-31 2002-02-13 Univ Yale Innate immune system-directed vaccines
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
ES2557282T3 (es) * 2008-03-10 2016-01-25 Children's Hospital & Research Center At Oakland Proteínas quiméricas de unión al factor H (fHBP) que contienen un dominio B heterólogo, y métodos de uso
BRPI0908936A2 (pt) * 2008-03-14 2017-03-28 Sanofi Pasteur Biologics Co vacinas de flavivírus de replicação defeituosa e vetores de vacina
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Also Published As

Publication number Publication date
CA2987306A1 (en) 2016-12-08
MX2017015404A (es) 2018-05-22
US11040010B2 (en) 2021-06-22
CN107847532A (zh) 2018-03-27
HK1253310A1 (zh) 2019-06-14
US20180153808A1 (en) 2018-06-07
EP3302511A1 (en) 2018-04-11
AU2016269722B2 (en) 2021-06-24
KR20180014756A (ko) 2018-02-09
JP7008900B2 (ja) 2022-02-10
AU2016269722A1 (en) 2017-12-07
US10639280B2 (en) 2020-05-05
WO2016193370A1 (en) 2016-12-08
JP2018521632A (ja) 2018-08-09
CN117247460A (zh) 2023-12-19
US20200197308A1 (en) 2020-06-25

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2725 DE 28-03-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.