BR112017018975A2 - proteínas de fusão compreendendo uma proteína de ligação e um polipeptídeo de interleucina-15 tendo uma afinidade reduzida com il15ra e usos terapêuticos das mesmas - Google Patents
proteínas de fusão compreendendo uma proteína de ligação e um polipeptídeo de interleucina-15 tendo uma afinidade reduzida com il15ra e usos terapêuticos das mesmasInfo
- Publication number
- BR112017018975A2 BR112017018975A2 BR112017018975-5A BR112017018975A BR112017018975A2 BR 112017018975 A2 BR112017018975 A2 BR 112017018975A2 BR 112017018975 A BR112017018975 A BR 112017018975A BR 112017018975 A2 BR112017018975 A2 BR 112017018975A2
- Authority
- BR
- Brazil
- Prior art keywords
- fusion proteins
- polypeptide
- binding protein
- il15ra
- interleukin
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 102000003812 Interleukin-15 Human genes 0.000 title 1
- 108090000172 Interleukin-15 Proteins 0.000 title 1
- 102000023732 binding proteins Human genes 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
a presente invenção refere-se às proteínas de fusão compreendendo uma proteína de ligação e um polipeptídeo de il-15 bem como seus usos, composições farmacêuticas compreendendo tais proteínas de fusão e um método para produzir tais proteínas de fusão.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15157911.7A EP3064507A1 (en) | 2015-03-06 | 2015-03-06 | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
EP15157911.7 | 2015-03-06 | ||
PCT/EP2016/054729 WO2016142314A1 (en) | 2015-03-06 | 2016-03-07 | FUSION PROTEINS COMPRISING A BINDING PROTEIN AND AN INTERLEUKIN-15 POLYPEPTIDE HAVING A REDUCED AFFINITY FOR IL15Ra AND THERAPEUTIC USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017018975A2 true BR112017018975A2 (pt) | 2018-04-17 |
Family
ID=52629425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017018975-5A BR112017018975A2 (pt) | 2015-03-06 | 2016-03-07 | proteínas de fusão compreendendo uma proteína de ligação e um polipeptídeo de interleucina-15 tendo uma afinidade reduzida com il15ra e usos terapêuticos das mesmas |
Country Status (16)
Country | Link |
---|---|
US (3) | US10906952B2 (pt) |
EP (2) | EP3064507A1 (pt) |
JP (1) | JP6757338B2 (pt) |
CN (1) | CN107636015A (pt) |
BR (1) | BR112017018975A2 (pt) |
CA (1) | CA2978808A1 (pt) |
CY (1) | CY1122494T1 (pt) |
DK (1) | DK3265478T3 (pt) |
ES (1) | ES2763598T3 (pt) |
HR (1) | HRP20192190T1 (pt) |
HU (1) | HUE047818T2 (pt) |
PL (1) | PL3265478T3 (pt) |
PT (1) | PT3265478T (pt) |
RS (1) | RS59658B1 (pt) |
SI (1) | SI3265478T1 (pt) |
WO (1) | WO2016142314A1 (pt) |
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CN107936121B (zh) | 2011-05-16 | 2022-01-14 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
CN106459914B (zh) | 2014-05-15 | 2020-11-06 | 新加坡国立大学 | 经修饰的自然杀伤细胞及其用途 |
EP3064507A1 (en) * | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
CN112574316A (zh) | 2015-07-02 | 2021-03-30 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
WO2017157305A1 (en) | 2016-03-15 | 2017-09-21 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
WO2017218533A1 (en) | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
AU2017342559B2 (en) | 2016-10-14 | 2022-03-24 | Xencor, Inc. | Bispecific heterodimeric fusion proteins containing IL-15/IL-15Ralpha Fc-fusion proteins and PD-1 antibody fragments |
BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
CN110494557A (zh) | 2017-03-27 | 2019-11-22 | 新加坡国立大学 | 用于离体扩增和活化自然杀伤细胞的刺激细胞系 |
UA125700C2 (uk) * | 2017-04-03 | 2022-05-18 | Ф. Хоффманн-Ля Рош Аг | Імунокон'югати антитіла до pd-1 з мутантом il-2 |
WO2019006472A1 (en) | 2017-06-30 | 2019-01-03 | Xencor, Inc. | TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS |
EP3664830A4 (en) | 2017-08-07 | 2020-07-01 | The Regents of the University of California | PLATFORM FOR GENERATING SAFE CELL THERAPEUTICS |
CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
AU2019224159A1 (en) * | 2018-02-26 | 2020-10-01 | Synthorx, Inc. | IL-15 conjugates and uses thereof |
WO2019166946A1 (en) * | 2018-02-28 | 2019-09-06 | Pfizer Inc. | Il-15 variants and uses thereof |
JP2021521784A (ja) | 2018-04-18 | 2021-08-30 | ゼンコア インコーポレイテッド | IL−15/IL−15RaFc融合タンパク質とPD−1抗原結合ドメインを含むPD−1標的化ヘテロダイマー融合タンパク質およびそれらの使用 |
US11505595B2 (en) | 2018-04-18 | 2022-11-22 | Xencor, Inc. | TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains |
WO2019246142A1 (en) * | 2018-06-18 | 2019-12-26 | Haiming Chen | Soluble bispecific fusion proteins for cancer immunotherapy |
CN113166266A (zh) * | 2018-06-18 | 2021-07-23 | 安维塔生物科学股份有限公司 | 抗间皮素构建体及其用途 |
WO2020048525A1 (en) * | 2018-09-07 | 2020-03-12 | Generon (Shanghai) Corporation Ltd. | Bispecific antigen binding proteins and uses thereof |
CN109207430A (zh) * | 2018-09-25 | 2019-01-15 | 华东师范大学 | 一种嵌合抗原受体nk细胞及其制备方法和应用 |
JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
WO2020069398A1 (en) | 2018-09-27 | 2020-04-02 | Akrevia Therapeutics Inc. | Masked cytokine polypeptides |
US11377477B2 (en) | 2018-10-12 | 2022-07-05 | Xencor, Inc. | PD-1 targeted IL-15/IL-15RALPHA fc fusion proteins and uses in combination therapies thereof |
EP3897853A1 (en) | 2018-12-20 | 2021-10-27 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
AU2020279534A1 (en) | 2019-05-20 | 2021-11-11 | Cytune Pharma | IL-2/IL-15Rβy agonist dosing regimens for treating cancer or infectious diseases |
WO2021009694A1 (en) * | 2019-07-17 | 2021-01-21 | National University Of Singapore | Functional binders synthesized and secreted by immune cells |
TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
CN111690068B (zh) * | 2019-11-13 | 2022-04-19 | 中国科学技术大学 | 一种IL-15/SuIL-15Rα-dFc-γ4复合体蛋白及其构造方法、应用 |
EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
WO2021115303A1 (zh) * | 2019-12-11 | 2021-06-17 | 上海复宏汉霖生物技术股份有限公司 | 一种抗Claudin18.2单克隆抗体、其制备方法及用途 |
AU2021343594A1 (en) * | 2020-09-17 | 2023-05-11 | Shanghai Lyn-Crest Enterprise Management Co., Ltd. | Bispecific recombinant protein and use thereof |
WO2022090203A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
WO2022090202A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER |
CN116635407A (zh) * | 2020-12-23 | 2023-08-22 | 瑞泽恩制药公司 | 编码锚修饰的抗体的核酸以及其用途 |
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AU2022325498A1 (en) | 2021-08-13 | 2024-02-01 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
CN113956346B (zh) * | 2021-10-26 | 2024-03-01 | 西安龙腾景云生物科技有限公司 | 一种重组白介素-15变体 |
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DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
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DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
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EP1430136A1 (en) | 2001-09-27 | 2004-06-23 | Pieris ProteoLab AG | Muteins of apolipoprotein d |
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EP1814988A2 (en) | 2004-11-26 | 2007-08-08 | Pieris AG | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
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JP6474797B2 (ja) | 2013-06-27 | 2019-02-27 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | インターロイキン15(il−15)アンタゴニスト並びに自己免疫疾患及び炎症性疾患の処置のためのその使用 |
EP3064507A1 (en) * | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
WO2019166946A1 (en) | 2018-02-28 | 2019-09-06 | Pfizer Inc. | Il-15 variants and uses thereof |
-
2015
- 2015-03-06 EP EP15157911.7A patent/EP3064507A1/en not_active Withdrawn
-
2016
- 2016-03-07 EP EP16708154.6A patent/EP3265478B1/en not_active Revoked
- 2016-03-07 BR BR112017018975-5A patent/BR112017018975A2/pt active Search and Examination
- 2016-03-07 SI SI201630550T patent/SI3265478T1/sl unknown
- 2016-03-07 CA CA2978808A patent/CA2978808A1/en active Pending
- 2016-03-07 PL PL16708154T patent/PL3265478T3/pl unknown
- 2016-03-07 RS RS20191593A patent/RS59658B1/sr unknown
- 2016-03-07 DK DK16708154.6T patent/DK3265478T3/da active
- 2016-03-07 PT PT167081546T patent/PT3265478T/pt unknown
- 2016-03-07 ES ES16708154T patent/ES2763598T3/es active Active
- 2016-03-07 WO PCT/EP2016/054729 patent/WO2016142314A1/en active Application Filing
- 2016-03-07 HU HUE16708154A patent/HUE047818T2/hu unknown
- 2016-03-07 JP JP2017564951A patent/JP6757338B2/ja active Active
- 2016-03-07 CN CN201680025275.8A patent/CN107636015A/zh active Pending
- 2016-03-07 US US15/556,282 patent/US10906952B2/en active Active
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2019
- 2019-12-04 HR HRP20192190TT patent/HRP20192190T1/hr unknown
- 2019-12-11 CY CY20191101303T patent/CY1122494T1/el unknown
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2020
- 2020-12-22 US US17/130,975 patent/US20210163564A1/en active Pending
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2021
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EP3265478B1 (en) | 2019-09-11 |
EP3265478A1 (en) | 2018-01-10 |
DK3265478T3 (da) | 2019-12-16 |
US20180044391A1 (en) | 2018-02-15 |
RS59658B1 (sr) | 2020-01-31 |
JP2018512168A (ja) | 2018-05-17 |
US20220324931A1 (en) | 2022-10-13 |
PT3265478T (pt) | 2020-01-08 |
HRP20192190T1 (hr) | 2020-02-21 |
SI3265478T1 (sl) | 2020-01-31 |
PL3265478T3 (pl) | 2020-03-31 |
WO2016142314A1 (en) | 2016-09-15 |
ES2763598T3 (es) | 2020-05-29 |
JP6757338B2 (ja) | 2020-09-16 |
CY1122494T1 (el) | 2021-01-27 |
CN107636015A (zh) | 2018-01-26 |
US20210163564A1 (en) | 2021-06-03 |
HUE047818T2 (hu) | 2020-05-28 |
CA2978808A1 (en) | 2016-09-15 |
US10906952B2 (en) | 2021-02-02 |
EP3064507A1 (en) | 2016-09-07 |
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