UY37970A - Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus - Google Patents

Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus

Info

Publication number
UY37970A
UY37970A UY0001037970A UY37970A UY37970A UY 37970 A UY37970 A UY 37970A UY 0001037970 A UY0001037970 A UY 0001037970A UY 37970 A UY37970 A UY 37970A UY 37970 A UY37970 A UY 37970A
Authority
UY
Uruguay
Prior art keywords
paenibacillus
methods
endosports
products
presentation platform
Prior art date
Application number
UY0001037970A
Other languages
English (en)
Inventor
L Golomb Benjamin
Dilara Ally
A Ficarra Florencia
Rauf Salamzade
A Traag Bjorn
Damian Curtis
Original Assignee
Bayer Cropscience Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Lp filed Critical Bayer Cropscience Lp
Publication of UY37970A publication Critical patent/UY37970A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/10—Animals; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/16—Enzymes or microbial cells immobilised on or in a biological cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2442—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01004—R,R-butanediol dehydrogenase (1.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01014—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Secuencias señal de utilidad para el direccionamiento de proteínas y péptidos hacia la superficie de endosporas producidas por miembros de la familia Paenibacillus y métodos para utilizar las mismas. Se provee también la presentación de moléculas heterólogas, tales como péptidos, polipéptidos y otras construcciones recombinantes, sobre la superficie de esporas de miembros de la familia Paenibacillus, usando secuencias de direccionamiento N-terminales particulares y derivados de las mismas y semejantes.
UY0001037970A 2017-11-16 2018-11-15 Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus UY37970A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762587371P 2017-11-16 2017-11-16

Publications (1)

Publication Number Publication Date
UY37970A true UY37970A (es) 2019-06-28

Family

ID=64746634

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037970A UY37970A (es) 2017-11-16 2018-11-15 Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus

Country Status (13)

Country Link
US (2) US10988769B2 (es)
EP (1) EP3710602A1 (es)
JP (1) JP2021508235A (es)
KR (1) KR20200083590A (es)
CN (1) CN111630172A (es)
AR (1) AR114339A1 (es)
AU (1) AU2018369878A1 (es)
BR (1) BR112020009618A2 (es)
CA (1) CA3082571A1 (es)
CL (1) CL2020001262A1 (es)
MX (1) MX2020005127A (es)
UY (1) UY37970A (es)
WO (1) WO2019099635A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114339A1 (es) 2017-11-16 2020-08-26 Bayer Cropscience Lp Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus
CN108034614B (zh) * 2018-01-19 2022-05-27 吉林农业大学 一种多粘类芽孢杆菌同时降解5种农药残留方法
US20220030876A1 (en) * 2018-09-20 2022-02-03 Bayer Cropscience Lp Methods of controlling animal pests with paenibacillus terrae
CN110055188A (zh) * 2019-03-07 2019-07-26 南京师范大学 一株产抑菌肽的多粘类芽孢杆菌xw4及其分离筛选和应用
AR118942A1 (es) * 2019-05-15 2021-11-10 Bayer Cropscience Lp Secuencias de selección dirigida para plataformas de visualización en endoesporas de paenibacillus
CN111235133B (zh) * 2019-09-30 2023-09-22 广西民族大学 嗜几丁质类芽孢杆菌几丁质酶基因及其克隆表达与应用
CN110699276A (zh) * 2019-09-30 2020-01-17 广西民族大学 一种嗜几丁质类芽孢杆菌的菌株及其应用
CN111060696B (zh) * 2019-12-27 2023-09-08 湖南农业大学 一种降低植物小分子信号肽假阳性率的方法
AU2021398989A1 (en) 2020-12-17 2023-07-06 Basf Se Spore compositions, production and uses thereof
CN112795519B (zh) * 2021-03-01 2023-01-10 千禾味业食品股份有限公司 一种暹罗芽孢杆菌及其在富含乙偶姻食醋中的应用
CN113999802B (zh) * 2021-11-23 2024-01-30 宁波希诺亚海洋生物科技有限公司 一种可表达高活性乳糖酶的黄瓜类芽孢杆菌菌株
CN115812739A (zh) * 2022-06-15 2023-03-21 福建省农业科学院植物保护研究所 湿地链霉菌菌株13-3及其发酵液在防治玉米茎腐病中的应用
CN115820464B (zh) * 2022-08-01 2023-06-16 江西农业大学 一株蜂窝孢类芽孢杆菌jauccb0001及其在促进长根菇生长中的应用
CN116286449B (zh) * 2022-10-28 2024-04-16 云南大学 一株能够促进蜜环菌生长的绿芽孢杆菌ysl-1-5及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272417A (en) 1979-05-22 1981-06-09 Cargill, Incorporated Stable protective seed coating
US4245432A (en) 1979-07-25 1981-01-20 Eastman Kodak Company Seed coatings
US4808430A (en) 1987-02-27 1989-02-28 Yazaki Corporation Method of applying gel coating to plant seeds
US5766914A (en) 1995-01-26 1998-06-16 Michigan State University Method of producing and purifying enzymes
US5800821A (en) 1995-03-10 1998-09-01 New England Medical Center Hospitals, Inc. Bacterial spores as a heat stable vaccine delivery system
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
US6503904B2 (en) 1998-11-16 2003-01-07 Syngenta Crop Protection, Inc. Pesticidal composition for seed treatment
AU2001273009A1 (en) 2000-06-26 2002-01-08 Maxygen, Inc. Methods and compositions for developing spore display systems for medicinal and industrial applications
US6660690B2 (en) 2000-10-06 2003-12-09 Monsanto Technology, L.L.C. Seed treatment with combinations of insecticides
KR20020045400A (ko) * 2000-12-08 2002-06-19 반재구 포자 표면발현 방법
KR100810527B1 (ko) 2001-01-15 2008-03-10 한국생명공학연구원 유전자 담체 표면 전시방법
US20020134012A1 (en) 2001-03-21 2002-09-26 Monsanto Technology, L.L.C. Method of controlling the release of agricultural active ingredients from treated plant seeds
WO2003102203A1 (en) * 2002-04-09 2003-12-11 Genofocus Co., Ltd. Stabilized biocatalysts and methods of bioconversion using the same
KR100518953B1 (ko) 2003-09-19 2005-10-12 주식회사 제노포커스 포자 외막단백질을 이용한 목적단백질의 표면발현 방법
WO2006012366A2 (en) 2004-07-20 2006-02-02 Phyllom Llc Methods for making and using recombinant bacillus thuringiensis spores
US9133251B2 (en) 2008-02-22 2015-09-15 The Curators Of The University Of Missouri Bacillus based delivery system and methods of use
CN103773708A (zh) * 2012-11-16 2014-05-07 江苏省农业科学院 一种防病促生长植物内生细菌
US9573980B2 (en) 2013-03-15 2017-02-21 Spogen Biotech Inc. Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots
CA3101008A1 (en) * 2013-12-24 2015-07-02 Indigo Ag, Inc. Plants containing beneficial endophytes
CA2961641A1 (en) 2014-09-17 2016-03-24 Spogen Biotech Inc. Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
CA2977493C (en) 2015-03-03 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Display platform from bacterial spore coat proteins
CN114292799A (zh) 2015-03-26 2022-04-08 拜耳作物科学有限合伙公司 新型类芽孢杆菌属菌株、抗真菌化合物以及它们的使用方法
AR114339A1 (es) 2017-11-16 2020-08-26 Bayer Cropscience Lp Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus

Also Published As

Publication number Publication date
CL2020001262A1 (es) 2020-11-06
US11702665B2 (en) 2023-07-18
AR114339A1 (es) 2020-08-26
US10988769B2 (en) 2021-04-27
WO2019099635A1 (en) 2019-05-23
US20210238610A1 (en) 2021-08-05
BR112020009618A2 (pt) 2020-11-24
US20190144874A1 (en) 2019-05-16
KR20200083590A (ko) 2020-07-08
CA3082571A1 (en) 2019-05-23
EP3710602A1 (en) 2020-09-23
JP2021508235A (ja) 2021-03-04
MX2020005127A (es) 2020-07-27
AU2018369878A1 (en) 2020-05-21
CN111630172A (zh) 2020-09-04

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