BR112017023228A2 - métodos para tratamento de câncer - Google Patents
métodos para tratamento de câncerInfo
- Publication number
- BR112017023228A2 BR112017023228A2 BR112017023228A BR112017023228A BR112017023228A2 BR 112017023228 A2 BR112017023228 A2 BR 112017023228A2 BR 112017023228 A BR112017023228 A BR 112017023228A BR 112017023228 A BR112017023228 A BR 112017023228A BR 112017023228 A2 BR112017023228 A2 BR 112017023228A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- methods
- cancer treatment
- rad1901
- everolimus
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 3
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010014733 Endometrial cancer Diseases 0.000 abstract 1
- 206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229960005167 everolimus Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562154699P | 2015-04-29 | 2015-04-29 | |
US201562155451P | 2015-04-30 | 2015-04-30 | |
US201562158469P | 2015-05-07 | 2015-05-07 | |
US201562192944P | 2015-07-15 | 2015-07-15 | |
US201562192940P | 2015-07-15 | 2015-07-15 | |
US201562252085P | 2015-11-06 | 2015-11-06 | |
US201562252916P | 2015-11-09 | 2015-11-09 | |
US201562265696P | 2015-12-10 | 2015-12-10 | |
US201562265663P | 2015-12-10 | 2015-12-10 | |
US201562265774P | 2015-12-10 | 2015-12-10 | |
US201562265658P | 2015-12-10 | 2015-12-10 | |
US201662323576P | 2016-04-15 | 2016-04-15 | |
US201662323572P | 2016-04-15 | 2016-04-15 | |
PCT/US2016/030316 WO2016176664A1 (en) | 2015-04-29 | 2016-04-29 | Methods for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017023228A2 true BR112017023228A2 (pt) | 2018-11-06 |
Family
ID=57198783
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017023233A BR112017023233A2 (pt) | 2015-04-29 | 2016-04-29 | métodos para tratamento de câncer |
BR112017023228A BR112017023228A2 (pt) | 2015-04-29 | 2016-04-29 | métodos para tratamento de câncer |
BR112017023269A BR112017023269A2 (pt) | 2015-04-29 | 2016-04-29 | métodos para tratamento de câncer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017023233A BR112017023233A2 (pt) | 2015-04-29 | 2016-04-29 | métodos para tratamento de câncer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017023269A BR112017023269A2 (pt) | 2015-04-29 | 2016-04-29 | métodos para tratamento de câncer |
Country Status (14)
Country | Link |
---|---|
US (10) | US20180214393A1 (pt) |
EP (4) | EP3288382A4 (pt) |
JP (7) | JP7019422B2 (pt) |
KR (3) | KR20180011780A (pt) |
CN (5) | CN108024541B (pt) |
AU (3) | AU2016256469B2 (pt) |
BR (3) | BR112017023233A2 (pt) |
CA (3) | CA2984357A1 (pt) |
HK (3) | HK1251407A1 (pt) |
IL (7) | IL307981A (pt) |
MX (6) | MX2021005561A (pt) |
RU (3) | RU2745678C2 (pt) |
SG (4) | SG11201708861VA (pt) |
WO (3) | WO2016176664A1 (pt) |
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IL307981A (en) * | 2015-04-29 | 2023-12-01 | Radius Pharmaceuticals Inc | Cancer treatment methods |
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TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
PL3518911T3 (pl) * | 2016-09-27 | 2022-02-07 | Radius Pharmaceuticals, Inc. | Rad1901 do zastosowania w leczeniu nowotworu jajnika |
PL3525774T3 (pl) * | 2016-10-11 | 2022-04-25 | Duke University | Leczenie lazofoksyfenem raka piersi er+ |
AU2017362460B2 (en) | 2016-11-17 | 2021-07-22 | Sanofi | Novel substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
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EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
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WO2019199891A1 (en) * | 2018-04-10 | 2019-10-17 | Duke University | Lasofoxifene treatment of breast cancer |
CN110585429B (zh) * | 2018-06-12 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 酪氨酸激酶抑制剂联合单克隆抗体以及紫杉醇类药物***疾病的用途 |
SG11202013177WA (en) * | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
CN112638869A (zh) | 2018-09-07 | 2021-04-09 | 赛诺菲 | 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法 |
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JOP20210137A1 (ar) * | 2018-12-06 | 2023-01-30 | Radius Pharmaceuticals Inc | طرق علاج سرطان مقاومة لمثبطات cdk4/6 |
AU2019392908A1 (en) * | 2018-12-06 | 2021-06-10 | Radius Pharmaceuticals, Inc. | Methods for treating cancer in models harboring ESR1 mutations |
KR102341347B1 (ko) * | 2019-11-28 | 2021-12-20 | 의료법인 성광의료재단 | 암 치료제에 대한 내성 암의 진단을 위한 조성물, 키트 및 방법 |
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