BR112017008042A2 - métodos e composições para dosagem em terapia de célula adotiva - Google Patents

métodos e composições para dosagem em terapia de célula adotiva

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Publication number
BR112017008042A2
BR112017008042A2 BR112017008042A BR112017008042A BR112017008042A2 BR 112017008042 A2 BR112017008042 A2 BR 112017008042A2 BR 112017008042 A BR112017008042 A BR 112017008042A BR 112017008042 A BR112017008042 A BR 112017008042A BR 112017008042 A2 BR112017008042 A2 BR 112017008042A2
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cells
receptors
dose
methods
doses
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BR112017008042A
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English (en)
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j gilbert Mark
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Juno Therapeutics Inc
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Publication of BR112017008042A2 publication Critical patent/BR112017008042A2/pt

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

a presente invenção refere-se a métodos para administração de doses múltiplas de células, tais como células t, a indivíduos para terapia celular. são também providas composições e artigos de fabricação para uso nos métodos. as células geralmente expressam receptores recombinantes tais como receptores quiméricos, por exem-plo, receptores de antígeno quiméricos (cars) ou outros receptores transgênicos tais como receptores de célula t (tcrs). os métodos envolvem geralmente administração de uma primeira dose e pelo menos uma consecutiva das células. a hora das doses com relação uma a outra, e/ou tamanho das doses, em algumas modalidades provê várias vantagens tais como toxidez menor ou reduzida e eficácia aperfeiçoada, por exemplo, devido à exposição aumentada do indivíduo às células administradas. em algumas modalidades, a primeira dose é uma dose relativamente baixa, tal como uma que reduz carga de tumor ou doença, desta maneira aperfeiçoando a eficácia de doses consecutivas ou subsequentes, e a dose consecutiva é uma dose de consolidação.
BR112017008042A 2014-10-20 2015-10-20 métodos e composições para dosagem em terapia de célula adotiva BR112017008042A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462066279P 2014-10-20 2014-10-20
US201562162647P 2015-05-15 2015-05-15
US201562168710P 2015-05-29 2015-05-29
US201562215732P 2015-09-08 2015-09-08
PCT/US2015/056532 WO2016064929A1 (en) 2014-10-20 2015-10-20 Methods and compositions for dosing in adoptive cell therapy

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BR112017008042A2 true BR112017008042A2 (pt) 2017-12-26

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US (3) US10507219B2 (pt)
EP (2) EP3209690B1 (pt)
JP (3) JP7057669B2 (pt)
KR (1) KR20170068598A (pt)
CN (2) CN117427091A (pt)
AU (1) AU2015336029B2 (pt)
BR (1) BR112017008042A2 (pt)
CA (1) CA2964941A1 (pt)
ES (1) ES2879612T3 (pt)
IL (2) IL293714A (pt)
MX (2) MX2017005106A (pt)
SG (2) SG11201703203RA (pt)
WO (1) WO2016064929A1 (pt)

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