BR112016020053A2 - métodos de previsão da reação de pacientes que sofrem de distúrbio inflamatório, de previsão da capacidade de reação de pacientes, de identificação de pacientes que sofrem de distúrbio inflamatório e de seu tratamento, usos de kit e kits - Google Patents
métodos de previsão da reação de pacientes que sofrem de distúrbio inflamatório, de previsão da capacidade de reação de pacientes, de identificação de pacientes que sofrem de distúrbio inflamatório e de seu tratamento, usos de kit e kitsInfo
- Publication number
- BR112016020053A2 BR112016020053A2 BR112016020053-5A BR112016020053A BR112016020053A2 BR 112016020053 A2 BR112016020053 A2 BR 112016020053A2 BR 112016020053 A BR112016020053 A BR 112016020053A BR 112016020053 A2 BR112016020053 A2 BR 112016020053A2
- Authority
- BR
- Brazil
- Prior art keywords
- kits
- predicting
- inflammatory disorder
- methods
- patients suffering
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
são fornecidos biomarcadores que preveem a capacidade de reação a antagonistas de integrina beta7, incluindo anticorpos de subunidade de antibeta7 integrina e métodos de uso desses biomarcadores. além disso, são fornecidos métodos de tratamento de distúrbios inflamatórios gastrointestinais tais como doenças intestinais inflamatórias, incluindo colite ulcerativa e mal de crohn. também são fornecidos métodos de uso desses biomarcadores de previsão para o tratamento de doenças intestinais inflamatórias, incluindo colite ulcerativa e mal de crohn.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461971379P | 2014-03-27 | 2014-03-27 | |
US61/971,379 | 2014-03-27 | ||
PCT/US2015/022762 WO2015148809A1 (en) | 2014-03-27 | 2015-03-26 | Methods for diagnosing and treating inflammatory bowel disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016020053A2 true BR112016020053A2 (pt) | 2018-02-20 |
Family
ID=54196399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016020053-5A BR112016020053A2 (pt) | 2014-03-27 | 2015-03-26 | métodos de previsão da reação de pacientes que sofrem de distúrbio inflamatório, de previsão da capacidade de reação de pacientes, de identificação de pacientes que sofrem de distúrbio inflamatório e de seu tratamento, usos de kit e kits |
Country Status (15)
Country | Link |
---|---|
US (4) | US10273542B2 (pt) |
EP (1) | EP3122377A4 (pt) |
JP (3) | JP7054990B2 (pt) |
KR (2) | KR102397324B1 (pt) |
CN (2) | CN106102767B (pt) |
AR (1) | AR099856A1 (pt) |
AU (3) | AU2015235986B2 (pt) |
BR (1) | BR112016020053A2 (pt) |
CA (1) | CA2939246A1 (pt) |
IL (2) | IL247266B (pt) |
MA (1) | MA39804A (pt) |
MX (2) | MX2016012282A (pt) |
RU (1) | RU2016136716A (pt) |
SG (1) | SG11201607938UA (pt) |
WO (1) | WO2015148809A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6219556B2 (ja) * | 2008-05-16 | 2017-10-25 | ジェネンテック, インコーポレイテッド | ベータ7インテグリンアンタゴニストを用いた消化管炎症性障害の治療評価のためのバイオマーカーの使用 |
MX2016012282A (es) | 2014-03-27 | 2017-01-06 | Genentech Inc | Metodos para diagnosticar y tratar enfermedad inflamatoria de intestino. |
AU2016222683A1 (en) * | 2015-02-26 | 2017-07-13 | Genentech, Inc. | Integrin beta7 antagonists and methods of treating crohn's disease |
GB201611738D0 (en) * | 2016-07-05 | 2016-08-17 | Cambridge Entpr Ltd | Biomarkers for inflammatory bowel disease |
CN107083423B (zh) * | 2017-03-27 | 2022-01-28 | 北京极客基因科技有限公司 | 一种药物靶点预测和药物全方面评价方法 |
WO2019200202A1 (en) | 2018-04-12 | 2019-10-17 | Morphic Therapeutic, Inc. | Antagonists of human integrin (alpha4)(beta7) |
EP3884276A2 (en) * | 2018-11-23 | 2021-09-29 | Katholieke Universiteit Leuven | Predicting a treatment response in inflammatory bowel disease |
JP2022523564A (ja) | 2019-03-04 | 2022-04-25 | アイオーカレンツ, インコーポレイテッド | 機械学習を使用するデータ圧縮および通信 |
UY38926A (es) | 2019-10-16 | 2021-05-31 | Morphic Therapeutic Inc | INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA |
IL300133A (en) | 2020-07-31 | 2023-03-01 | Genentech Inc | Anti-integrin antibody compositions in cell 7 and devices |
WO2023061502A1 (zh) * | 2021-10-15 | 2023-04-20 | 苏州生物医药转化工程中心 | 一种双特异性结合分子 |
CN114085908B (zh) * | 2021-10-30 | 2023-08-08 | 中国人民解放军陆军军医大学第一附属医院 | 用于评估胶质母细胞瘤治疗效果的基因靶点组合及其应用 |
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2015
- 2015-03-26 MX MX2016012282A patent/MX2016012282A/es unknown
- 2015-03-26 CN CN201580016240.3A patent/CN106102767B/zh active Active
- 2015-03-26 CA CA2939246A patent/CA2939246A1/en active Pending
- 2015-03-26 JP JP2016559188A patent/JP7054990B2/ja active Active
- 2015-03-26 AR ARP150100901A patent/AR099856A1/es unknown
- 2015-03-26 CN CN202110901698.4A patent/CN113604543A/zh active Pending
- 2015-03-26 RU RU2016136716A patent/RU2016136716A/ru not_active Application Discontinuation
- 2015-03-26 AU AU2015235986A patent/AU2015235986B2/en active Active
- 2015-03-26 BR BR112016020053-5A patent/BR112016020053A2/pt not_active Application Discontinuation
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2016
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2019
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2020
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2021
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2022
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