BR112015027281A8 - usos de uma população de nanocarreadores sintéticos que são fixados a imunossupressores e composição compreendendo a referida população de nanocarreadores - Google Patents

usos de uma população de nanocarreadores sintéticos que são fixados a imunossupressores e composição compreendendo a referida população de nanocarreadores Download PDF

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Publication number
BR112015027281A8
BR112015027281A8 BR112015027281A BR112015027281A BR112015027281A8 BR 112015027281 A8 BR112015027281 A8 BR 112015027281A8 BR 112015027281 A BR112015027281 A BR 112015027281A BR 112015027281 A BR112015027281 A BR 112015027281A BR 112015027281 A8 BR112015027281 A8 BR 112015027281A8
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Prior art keywords
population
nanocarriers
immunosuppressants
synthetic nanocarriers
attached
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BR112015027281A
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English (en)
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BR112015027281B1 (pt
BR112015027281A2 (pt
Inventor
A Maldonado Roberto
Kei Kishimoto Takashi
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Selecta Biosciences Inc
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Priority claimed from PCT/US2014/036698 external-priority patent/WO2014179771A1/en
Publication of BR112015027281A2 publication Critical patent/BR112015027281A2/pt
Publication of BR112015027281A8 publication Critical patent/BR112015027281A8/pt
Publication of BR112015027281B1 publication Critical patent/BR112015027281B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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Abstract

abstract disclosed are dosings of therapeutic macromolecules and immunosuppressants, in some embodiments attached to synthetic nanocarriers, in combination with dosings of therapeutic macromolecules without synthetic nanocarriers, and related methods that provide reduced humoral immune responses. ____________________________________________ resumo patente de invenção: "combinações de dosagens para reduzir respostas imunológicas humorais indesejadas". a presente invenção se refere a dosagens de macromoléculas terapêuticas e imunossupressores, em algumas modalidades fixados a nanocarreadores sintéticos, em combinação com dosagens de macromoléculas terapêuticas sem nanocarreadores sintéticos e métodos relacionados que fornecem respostas imunológica humorais reduzidas.
BR112015027281-9A 2013-05-03 2014-05-02 Composições compreendendo macromoléculas terapêuticas e uma população de nanocarreadores sintéticos que são fixados a imunossupressores BR112015027281B1 (pt)

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US201361819517P 2013-05-03 2013-05-03
US61/819,517 2013-05-03
US201361881921P 2013-09-24 2013-09-24
US201361881913P 2013-09-24 2013-09-24
US201361881851P 2013-09-24 2013-09-24
US61/881,921 2013-09-24
US201361907177P 2013-11-21 2013-11-21
US61/907,177 2013-11-21
US201461948313P 2014-03-05 2014-03-05
US201461948384P 2014-03-05 2014-03-05
US61/948,313 2014-03-05
US61/948,384 2014-03-05
PCT/US2014/036698 WO2014179771A1 (en) 2013-05-03 2014-05-02 Dosing combinations for reducing undesired humoral immune responses

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BR112015027280A BR112015027280A8 (pt) 2013-05-03 2014-05-02 nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico
BR112015027281-9A BR112015027281B1 (pt) 2013-05-03 2014-05-02 Composições compreendendo macromoléculas terapêuticas e uma população de nanocarreadores sintéticos que são fixados a imunossupressores
BR112015027288-6A BR112015027288B1 (pt) 2013-05-03 2014-05-02 Composição que compreende um inibidor de mtor ligado a nanocarreadores sintéticos poliméricos
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