BR112015025804A2 - derivados de glutarimida, uso dos mesmos, composição farmacêutica com base neles e métodos para a produção de derivados de glutarimida - Google Patents

derivados de glutarimida, uso dos mesmos, composição farmacêutica com base neles e métodos para a produção de derivados de glutarimida

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Publication number
BR112015025804A2
BR112015025804A2 BR112015025804A BR112015025804A BR112015025804A2 BR 112015025804 A2 BR112015025804 A2 BR 112015025804A2 BR 112015025804 A BR112015025804 A BR 112015025804A BR 112015025804 A BR112015025804 A BR 112015025804A BR 112015025804 A2 BR112015025804 A2 BR 112015025804A2
Authority
BR
Brazil
Prior art keywords
glutarimide derivatives
methods
derivatives
glutarimide
formula
Prior art date
Application number
BR112015025804A
Other languages
English (en)
Other versions
BR112015025804B1 (pt
Inventor
Alexandrovna Kromova Tatyana
Evgenievich Nebolsin Vladimir
Original Assignee
Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2013116826A external-priority patent/RU2562773C3/ru
Application filed by Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises filed Critical Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises
Priority to BR122020010204-7A priority Critical patent/BR122020010204B1/pt
Publication of BR112015025804A2 publication Critical patent/BR112015025804A2/pt
Publication of BR112015025804B1 publication Critical patent/BR112015025804B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

abstract the present invention relates to novel biologically active glutarimide derivatives of general formula i or pharmaceutically acceptable salts thereof, their use as an agent for the treatment of upper respiratory tract diseases, pharmaceutical compositions comprising the glutarimide derivatives of general formula i, methods for preparing the glutarimide derivatives of general formula i by heating a dicarboxylic acid monoamide of general formula ii with a dehydrating agent. ______________________________________________________________ resumo patente de invenção: "derivados de glutarimida, uso dos mesmos, composição farmacêutica com base neles e métodos para a produção de derivados de glutarimida". a presente invenção refere-se a novos derivados de glutarimida biologicamente ativos de fórmula geral i ou sais farmaceuticamente aceitáveis dos mesmos, o uso dos mesmos como agentes para tratar doenças do trato respiratório superior, composições farmacêuticas, compreendendo os derivados de glutarimida de fórmula geral i, métodos para a preparação dos derivados de glutarimida de fórmula geral i, por aquecimento de uma monoamida de ácido dicarboxílico de fórmula geral ii, com um agente de desidratação.
BR112015025804-2A 2013-04-12 2014-04-10 Derivados de glutarimida, uso dos mesmos, composição farmacêutica com base neles e métodos para a produção de derivados de glutarimida BR112015025804B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020010204-7A BR122020010204B1 (pt) 2013-04-12 2014-04-10 Composto derivado de glutarimida, seu uso, composiçâo farmacêutica e método de de preparação

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2013116826 2013-04-12
RU2013116826A RU2562773C3 (ru) 2013-04-12 Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения
PCT/RU2014/000264 WO2014168522A1 (ru) 2013-04-12 2014-04-10 Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения

Publications (2)

Publication Number Publication Date
BR112015025804A2 true BR112015025804A2 (pt) 2017-07-25
BR112015025804B1 BR112015025804B1 (pt) 2022-01-04

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
BR112015025804-2A BR112015025804B1 (pt) 2013-04-12 2014-04-10 Derivados de glutarimida, uso dos mesmos, composição farmacêutica com base neles e métodos para a produção de derivados de glutarimida
BR122020010210-1A BR122020010210B1 (pt) 2013-04-12 2014-04-10 Composto derivado de glutarimida, seu uso, composição farmacêutica e método de preparação do mesmo
BR122020010204-7A BR122020010204B1 (pt) 2013-04-12 2014-04-10 Composto derivado de glutarimida, seu uso, composiçâo farmacêutica e método de de preparação

Family Applications After (2)

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BR122020010210-1A BR122020010210B1 (pt) 2013-04-12 2014-04-10 Composto derivado de glutarimida, seu uso, composição farmacêutica e método de preparação do mesmo
BR122020010204-7A BR122020010204B1 (pt) 2013-04-12 2014-04-10 Composto derivado de glutarimida, seu uso, composiçâo farmacêutica e método de de preparação

Country Status (15)

Country Link
US (8) US9815814B2 (pt)
EP (3) EP3722290B1 (pt)
JP (4) JP6529958B2 (pt)
KR (3) KR102255929B1 (pt)
CN (4) CN110229140B (pt)
AU (5) AU2014251442A1 (pt)
BR (3) BR112015025804B1 (pt)
CA (1) CA2909057C (pt)
EA (4) EA032938B1 (pt)
IL (4) IL266301B2 (pt)
MX (4) MX2015014336A (pt)
SG (4) SG11201508394UA (pt)
UA (1) UA121299C2 (pt)
WO (1) WO2014168522A1 (pt)
ZA (3) ZA201508278B (pt)

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CN106539792B (zh) * 2016-11-07 2017-08-25 王晓旭 一种治疗高血脂症的药物
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JP2022506892A (ja) * 2018-11-01 2022-01-17 アハンムネ バイオサイエンシーズ プライベート リミテッド 新規なイミダゾール化合物、その合成法及びその使用
RU2712281C1 (ru) 2018-11-23 2020-01-28 Общество С Ограниченной Ответственностью "Хемиммьюн Терапьютикс" Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма
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AU2020203632B2 (en) 2021-04-22
EP3722290A1 (en) 2020-10-14
SG11201508394UA (en) 2015-11-27
KR102254315B1 (ko) 2021-05-25
MX2020005738A (es) 2021-08-13
US20180016255A1 (en) 2018-01-18
BR122020010204B1 (pt) 2022-03-03
ZA201603108B (en) 2017-08-30
US10377739B2 (en) 2019-08-13
EP2985282A4 (en) 2017-02-22
KR102255929B1 (ko) 2021-05-26
ZA201508278B (en) 2017-11-29
KR20200069381A (ko) 2020-06-16
RU2013116826A (ru) 2014-10-20
IL266301B2 (en) 2023-03-01
KR20200069380A (ko) 2020-06-16
MX2020005736A (es) 2021-06-14
JP6843103B2 (ja) 2021-03-17
IL266301A (en) 2019-06-30
US10155744B2 (en) 2018-12-18
US10155746B2 (en) 2018-12-18
JP6529958B2 (ja) 2019-06-12
US10196377B2 (en) 2019-02-05
SG10201802647QA (en) 2018-05-30
CN110229140A (zh) 2019-09-13
SG10201802648SA (en) 2018-05-30
AU2020203630B2 (en) 2021-04-22
CA2909057A1 (en) 2014-10-16
AU2018236805C1 (en) 2020-11-05
EP3722290B1 (en) 2023-06-21
US10155745B2 (en) 2018-12-18
EA201792071A2 (ru) 2018-04-30
JP6620324B2 (ja) 2019-12-18
JP2019034966A (ja) 2019-03-07
EA032938B1 (ru) 2019-08-30
UA121299C2 (uk) 2020-05-12
IL266300A (en) 2019-06-30
SG10201802650WA (en) 2018-05-30
US9815814B2 (en) 2017-11-14
WO2014168522A4 (ru) 2015-01-22
WO2014168522A9 (ru) 2014-12-04
US10155747B2 (en) 2018-12-18
US20180016254A1 (en) 2018-01-18
JP2016516766A (ja) 2016-06-09
EA201792597A3 (ru) 2018-09-28
IL266300B (en) 2021-10-31
US20180016256A1 (en) 2018-01-18
EA201591957A1 (ru) 2016-02-29
MX2015014336A (es) 2016-06-07
KR20160021092A (ko) 2016-02-24
EA033054B1 (ru) 2019-08-30
EA201792072A2 (ru) 2018-04-30
CN110128406B (zh) 2021-08-27
EA031392B1 (ru) 2018-12-28
JP2019034965A (ja) 2019-03-07
MX2020005735A (es) 2021-06-21
CN106061962A (zh) 2016-10-26
WO2014168522A1 (ru) 2014-10-16
RU2562773C2 (ru) 2015-09-10
EP2985282A1 (en) 2016-02-17
US20180022728A1 (en) 2018-01-25
US20160046598A1 (en) 2016-02-18
AU2018236805B2 (en) 2020-04-09
JP2019034964A (ja) 2019-03-07
IL241998B (en) 2019-06-30
BR122020010210B1 (pt) 2022-09-20
EA201792071A3 (ru) 2018-09-28
AU2014251442A1 (en) 2015-12-03
IL266302A (en) 2019-06-30
ZA201603109B (en) 2017-08-30
JP6627039B2 (ja) 2020-01-08
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