BR112015018168A2 - inibidores de rock suaves - Google Patents
inibidores de rock suavesInfo
- Publication number
- BR112015018168A2 BR112015018168A2 BR112015018168A BR112015018168A BR112015018168A2 BR 112015018168 A2 BR112015018168 A2 BR 112015018168A2 BR 112015018168 A BR112015018168 A BR 112015018168A BR 112015018168 A BR112015018168 A BR 112015018168A BR 112015018168 A2 BR112015018168 A2 BR 112015018168A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- relates
- treatment
- prophylaxis
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
Abstract
abstract the present invention relates to new kinase inhibitors, more specifically rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. in particular, the present invention relates to new rock inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. in addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including respiratory and gastro-intestinal diseases. tradução do resumo resumo patente de invenção para "inibidores de rock suaves". a presente invenção se relaciona a novos inibidores de cinase, mais especificamente, inibidores de rock, composições, em particular, farmacêuticos, compreendendo tais inibidores, e aos usos de tais inibidores no tratamento e profilaxia de doença. em particular, a presente invenção se relaciona a novos inibidores de rock, composições, em particular, farmacêuticos, compreendendo tais inibidores, e aos usos de tais inibidores no tratamento e profilaxia de doença. em adição, a invenção se relaciona a métodos de tratamento e uso de referidos compostos na fabricação de um medicamento para a aplicação a um número de indicações terapêuticas, incluindo doenças respiratórias e doenças gastrointestinais.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13153094 | 2013-01-29 | ||
| EP13153094.1 | 2013-01-29 | ||
| GB1303494.7 | 2013-02-27 | ||
| GB201303494A GB201303494D0 (en) | 2013-02-27 | 2013-02-27 | Novel soft rock inhibitors |
| PCT/EP2014/051546 WO2014118133A1 (en) | 2013-01-29 | 2014-01-27 | Pyridine derivatives as soft rock inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015018168A2 true BR112015018168A2 (pt) | 2017-07-18 |
| BR112015018168B1 BR112015018168B1 (pt) | 2023-04-11 |
Family
ID=50112877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015018168-6A BR112015018168B1 (pt) | 2013-01-29 | 2014-01-27 | Derivados de piridina e composição que os compreende derivados de piridina e composição que os compreende |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9682963B2 (pt) |
| EP (1) | EP2951172B8 (pt) |
| KR (1) | KR102275616B1 (pt) |
| CN (1) | CN105026387B (pt) |
| AU (1) | AU2014211580B2 (pt) |
| BR (1) | BR112015018168B1 (pt) |
| CA (1) | CA2898674C (pt) |
| CY (1) | CY1119227T1 (pt) |
| DK (1) | DK2951172T3 (pt) |
| EA (1) | EA029653B1 (pt) |
| ES (1) | ES2629762T3 (pt) |
| HK (1) | HK1215706A1 (pt) |
| HR (1) | HRP20170940T1 (pt) |
| HU (1) | HUE033962T2 (pt) |
| IL (1) | IL240363B (pt) |
| LT (1) | LT2951172T (pt) |
| MX (1) | MX367818B (pt) |
| NZ (1) | NZ711424A (pt) |
| PL (1) | PL2951172T3 (pt) |
| PT (1) | PT2951172T (pt) |
| RS (1) | RS56089B1 (pt) |
| SG (1) | SG11201505867PA (pt) |
| SI (1) | SI2951172T1 (pt) |
| WO (1) | WO2014118133A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| AR110401A1 (es) | 2016-12-21 | 2019-03-27 | Chiesi Farm Spa | Derivados dihidropirimidina bicíclica-carboxamida como inhibidores de rho-quinasa |
| SG11201906134YA (en) | 2017-01-30 | 2019-08-27 | Chiesi Farm Spa | Tyrosine amide derivatives as rho- kinase inhibitors |
| AU2018326785B2 (en) | 2017-09-03 | 2023-03-02 | Angion Biomedica Corp. | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors |
| US11147812B2 (en) | 2017-09-07 | 2021-10-19 | Chiesi Farmaceutici S.P.A. | Tyrosine analogues derivatives as Rho-kinase inhibitors |
| US11332468B2 (en) | 2017-12-18 | 2022-05-17 | Chiesi Farmaceutici S.P.A. | Azaindole derivatives as Rho-kinase inhibitors |
| MA51284A (fr) | 2017-12-18 | 2021-05-26 | Chiesi Farm Spa | Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho |
| MA51283A (fr) | 2017-12-18 | 2021-05-26 | Chiesi Farm Spa | Dérivés de tyrosine en tant qu'inhibiteurs de kinase rho |
| PL3759109T3 (pl) | 2018-02-26 | 2024-03-04 | Gilead Sciences, Inc. | Podstawione związki pirolizyny jako inhibitory replikacji hbv |
| AR114926A1 (es) | 2018-06-13 | 2020-10-28 | Chiesi Farm Spa | Derivados de azaindol como inhibidores de rho-quinasa |
| TW202019923A (zh) | 2018-07-16 | 2020-06-01 | 義大利商吉斯藥品公司 | 作為Ｒｈｏ－激酶抑制劑之酪胺酸醯胺衍生物 |
| CN110917352A (zh) * | 2019-10-22 | 2020-03-27 | 天津医科大学肿瘤医院 | Rock抑制剂在肿瘤免疫治疗中的新用法 |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| CN116568303A (zh) | 2020-12-15 | 2023-08-08 | 奇斯药制品公司 | 作为rho-激酶抑制剂的二氢呋喃并吡啶衍生物 |
| MX2023005867A (es) | 2020-12-15 | 2023-06-05 | Chiesi Farm Spa | Derivados de dihidrofuropiridina como inhibidores de la cinasa rho. |
| KR20230121812A (ko) | 2020-12-15 | 2023-08-21 | 키에시 파르마슈티시 엣스. 피. 에이. | Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체 |
| IL308953A (en) | 2021-06-04 | 2024-01-01 | Vertex Pharma | N-Hydroalkyl(Hetero)Aryl)Tetrahydrofuran Carboxamides as Natrene Channel Modulators |
| WO2023110700A1 (en) | 2021-12-13 | 2023-06-22 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho-kinase inhibitors |
| WO2024052704A1 (en) | 2022-09-08 | 2024-03-14 | Redx Pharma Plc | Solid forms of a rock inhibitor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| CN101248046A (zh) * | 2005-07-11 | 2008-08-20 | 德福根有限公司 | 作为激酶抑制剂的酰胺衍生物 |
| EP1934181A2 (en) * | 2005-10-13 | 2008-06-25 | Devgen NV | Kinase inhibitors |
| EP2626348A1 (en) * | 2010-03-02 | 2013-08-14 | Amakem NV | Heterocyclic amides as rock inhibitors |
| GB201114854D0 (en) | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
| CA2846752A1 (en) * | 2011-08-31 | 2013-03-07 | Amakem Nv | Biphenylcarboxamides as rock kinase inhibitors |
-
2014
- 2014-01-27 DK DK14704532.2T patent/DK2951172T3/en active
- 2014-01-27 SI SI201430261T patent/SI2951172T1/sl unknown
- 2014-01-27 WO PCT/EP2014/051546 patent/WO2014118133A1/en active Application Filing
- 2014-01-27 CA CA2898674A patent/CA2898674C/en active Active
- 2014-01-27 PL PL14704532T patent/PL2951172T3/pl unknown
- 2014-01-27 PT PT147045322T patent/PT2951172T/pt unknown
- 2014-01-27 ES ES14704532.2T patent/ES2629762T3/es active Active
- 2014-01-27 AU AU2014211580A patent/AU2014211580B2/en active Active
- 2014-01-27 HU HUE14704532A patent/HUE033962T2/en unknown
- 2014-01-27 KR KR1020157023210A patent/KR102275616B1/ko active IP Right Grant
- 2014-01-27 NZ NZ711424A patent/NZ711424A/en unknown
- 2014-01-27 EA EA201591371A patent/EA029653B1/ru unknown
- 2014-01-27 SG SG11201505867PA patent/SG11201505867PA/en unknown
- 2014-01-27 US US14/763,594 patent/US9682963B2/en active Active
- 2014-01-27 LT LTEP14704532.2T patent/LT2951172T/lt unknown
- 2014-01-27 CN CN201480010186.7A patent/CN105026387B/zh active Active
- 2014-01-27 RS RS20170620A patent/RS56089B1/sr unknown
- 2014-01-27 BR BR112015018168-6A patent/BR112015018168B1/pt active IP Right Grant
- 2014-01-27 MX MX2015009674A patent/MX367818B/es active IP Right Grant
- 2014-01-27 EP EP14704532.2A patent/EP2951172B8/en active Active
-
2015
- 2015-08-04 IL IL240363A patent/IL240363B/en active IP Right Grant
-
2016
- 2016-03-30 HK HK16103655.2A patent/HK1215706A1/zh unknown
-
2017
- 2017-05-15 US US15/595,219 patent/US9850234B2/en active Active
- 2017-06-20 HR HRP20170940TT patent/HRP20170940T1/hr unknown
- 2017-06-28 CY CY20171100684T patent/CY1119227T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: REDX PHARMA PLC (GB) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/01/2014, OBSERVADAS AS CONDICOES LEGAIS |