BR112014001898A2 - quinolinas substituídas e seu uso como medicamentos - Google Patents

quinolinas substituídas e seu uso como medicamentos

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Publication number
BR112014001898A2
BR112014001898A2 BR112014001898A BR112014001898A BR112014001898A2 BR 112014001898 A2 BR112014001898 A2 BR 112014001898A2 BR 112014001898 A BR112014001898 A BR 112014001898A BR 112014001898 A BR112014001898 A BR 112014001898A BR 112014001898 A2 BR112014001898 A2 BR 112014001898A2
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Brazil
Prior art keywords
group
substituted
heteroatoms
independently selected
optionally
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BR112014001898A
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English (en)
Inventor
Mccarthy Clive
Bischoff Daniel
Jacques Marlin Frederic
Dahmann Georg
Schaenzle Gerhard
Klicic Jasna
Scott John
Hoffmann Matthias
Gaston Convers- Reignier Serge
Ludwig Michael Wollin Stefan
Peter East Stephen
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Boehringer Ingelheim Int
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112014001898A2 publication Critical patent/BR112014001898A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Abstract

resumo patente de invenção: "quinolinas substituídas e seu uso como medicamentos". a presente invenção refere-se a novas quinolinas substituídas de fórmula (1) 1, em que r1 é uma c1-6-alquila linear ou ramificada, em que r1 pode opcionalmente ser substituído por r3 que é selecionado a partir do grupo que consiste em uma cicloalquila de três, quatro, cinco, seis ou sete membros; um heterociclo de cinco, seis ou sete membros, saturado compreendendo um, dois ou três heteroátomos cada qual independentemente selecionado a partir do grupo que consiste em n, s e o; e uma heteroarila de cinco ou seis membros compreendendo um, dois ou três heteroátomos cada qual independentemente selecionado a partir do grupo que consiste em n, s e o; em que r3 pode opcionalmente ser também substituído como definido na reivindicação 1 e em que r2 é selecionado a partir do grupo que consiste em halogênio, fenila, uma heteroarila de cinco ou seis membros monocíclica compreendendo um, dois ou três heteroátomos cada qual independentemente selecionado a partir do grupo que consiste em n, s e o; um heterociclo bicíclico, de nove, dez ou onze membros, aromático ou não aromático, porém não completamente saturado compreendendo um, dois, três ou quatro heteroátomos cada qual independentemente selecionado a partir do grupo que consiste em n, s e o; em que r2 pode opcionalmente ser também substituído como definido na reivindicação 1, e seu uso na preparação de medicamentos para o tratamento de doença tal como asma, copd, rinite alérgica, dermatite alérgica e artrite reumatoide.
BR112014001898A 2011-07-26 2012-07-19 quinolinas substituídas e seu uso como medicamentos BR112014001898A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11175444 2011-07-26
PCT/EP2012/064172 WO2013014060A1 (en) 2011-07-26 2012-07-19 Substituted quinolines and their use as medicaments

Publications (1)

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BR112014001898A2 true BR112014001898A2 (pt) 2017-02-21

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US (2) US8912173B2 (pt)
EP (1) EP2736886B1 (pt)
JP (1) JP5860960B2 (pt)
KR (1) KR101986484B1 (pt)
CN (1) CN103827090B (pt)
AR (1) AR087311A1 (pt)
AU (1) AU2012288969B2 (pt)
BR (1) BR112014001898A2 (pt)
CA (1) CA2843022C (pt)
CL (1) CL2014000113A1 (pt)
EA (1) EA024845B1 (pt)
IL (1) IL229963A (pt)
MX (1) MX336224B (pt)
UY (1) UY34221A (pt)
WO (1) WO2013014060A1 (pt)

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