BR112014001634A2 - compostos bicíclicos de pirimidona - Google Patents
compostos bicíclicos de pirimidonaInfo
- Publication number
- BR112014001634A2 BR112014001634A2 BR112014001634A BR112014001634A BR112014001634A2 BR 112014001634 A2 BR112014001634 A2 BR 112014001634A2 BR 112014001634 A BR112014001634 A BR 112014001634A BR 112014001634 A BR112014001634 A BR 112014001634A BR 112014001634 A2 BR112014001634 A2 BR 112014001634A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidone compounds
- bicyclic pyrimidone
- bicyclic
- compounds
- pla2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
resumo “compostos bicíclicos de pirimidona” a presente invenção diz respeito a novos compostos bicíclicos de pirimidona que inibem a atividade de lp-pla2, a processos para prepará-los, a composições os contendo e ao seu uso no tratamento de doenças associadas com a atividade de lp-pla2, por exemplo, aterosclerose, doença de alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011077702 | 2011-07-27 | ||
PCT/EP2012/064598 WO2013014185A1 (en) | 2011-07-27 | 2012-07-25 | Bicyclic pyrimidone compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014001634A2 true BR112014001634A2 (pt) | 2017-02-14 |
Family
ID=46579034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014001634A BR112014001634A2 (pt) | 2011-07-27 | 2012-07-25 | compostos bicíclicos de pirimidona |
Country Status (12)
Country | Link |
---|---|
US (2) | US9273054B2 (pt) |
EP (1) | EP2736908A1 (pt) |
JP (1) | JP2014521625A (pt) |
KR (1) | KR20140059204A (pt) |
AR (1) | AR087309A1 (pt) |
AU (1) | AU2012288865B2 (pt) |
BR (1) | BR112014001634A2 (pt) |
CA (1) | CA2843102A1 (pt) |
RU (1) | RU2014107486A (pt) |
TW (1) | TW201321382A (pt) |
UY (1) | UY34216A (pt) |
WO (1) | WO2013014185A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2014107486A (ru) * | 2011-07-27 | 2015-09-10 | Глэксо Груп Лимитед | Бициклические пиримидоновые соединения |
EP2928873A1 (en) | 2012-11-27 | 2015-10-14 | Basf Se | Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides |
WO2014082871A1 (en) | 2012-11-27 | 2014-06-05 | Basf Se | Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides |
WO2014082880A1 (en) | 2012-11-27 | 2014-06-05 | Basf Se | Substituted [1,2,4] triazole compounds |
CN104968665A (zh) * | 2013-01-25 | 2015-10-07 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为lp-pla2抑制剂的双环嘧啶酮化合物 |
WO2014114248A1 (en) * | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
JP2016505053A (ja) * | 2013-01-25 | 2016-02-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Lp‐PLA2の阻害剤としての二環式ピリミドン化合物 |
US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
KR20170034889A (ko) * | 2014-07-22 | 2017-03-29 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화합물 |
CN105777653A (zh) * | 2014-12-26 | 2016-07-20 | 中国科学院上海药物研究所 | 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物 |
CN106188063A (zh) * | 2015-05-08 | 2016-12-07 | 中国科学院上海药物研究所 | 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途 |
EP3344632A4 (en) * | 2015-09-04 | 2019-03-20 | Lysosomal Therapeutics Inc. | Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders |
GB201522179D0 (en) * | 2015-12-16 | 2016-01-27 | Autifony Therapeutics Ltd | Novel compounds |
EP3752503A1 (en) | 2018-02-16 | 2020-12-23 | Boehringer Ingelheim International GmbH | Inhibitors of trpc6 |
CN112574221B (zh) * | 2019-09-30 | 2022-03-04 | 上海纽思克生物科技有限公司 | 四环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN112778331B (zh) | 2019-11-09 | 2022-07-05 | 上海赛默罗生物科技有限公司 | 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途 |
CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9421816D0 (en) | 1994-10-29 | 1994-12-14 | Smithkline Beecham Plc | Novel compounds |
PL320937A1 (en) | 1994-12-22 | 1997-11-10 | Smithkline Beecham Plc | Substituted azetidin-2-ones for treating arterial atheromatosis |
CH690264A5 (fr) | 1995-06-30 | 2000-06-30 | Symphar Sa | Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques. |
PL324240A1 (en) | 1995-07-01 | 1998-05-11 | Smithkline Beecham Plc | Derivatives of azetidinone for treating atherosclerosis |
WO1997012963A2 (en) | 1995-09-29 | 1997-04-10 | Smithkline Beecham Plc | A paf-acetylhydrolase and use in therapy |
WO1997021676A1 (en) | 1995-12-08 | 1997-06-19 | Smithkline Beecham Plc | Azetidinone compounds for the treatment of atherosclerosis |
JP2000502079A (ja) | 1995-12-08 | 2000-02-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体 |
GB9608649D0 (en) | 1996-04-26 | 1996-07-03 | Smithkline Beecham Plc | Novel compounds |
BR9709196A (pt) | 1996-04-26 | 1999-05-25 | Smithkline Beecham Plc | Derivados de azetidinona para o tratamento de aterosclerose |
GB9626615D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
GB9626536D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
GB9626616D0 (en) | 1996-12-20 | 1997-02-05 | Symphar Sa | Novel compounds |
JP2001522844A (ja) | 1997-11-06 | 2001-11-20 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ピリミジノン化合物およびそれを含有する医薬組成物 |
ATE251613T1 (de) | 1998-08-21 | 2003-10-15 | Smithkline Beecham Plc | Pyrimidinonderivate zur behandlung von atheroscleros |
GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
BR0010220A (pt) | 1999-05-01 | 2002-05-14 | Smithkline Beecham Plc | Compostos de pirimidinona |
GB9910378D0 (en) | 1999-05-05 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
JP3757703B2 (ja) | 1999-09-22 | 2006-03-22 | 凸版印刷株式会社 | 再封可能な開口維持部材付パウチ |
WO2001060805A1 (en) | 2000-02-16 | 2001-08-23 | Smithkline Beecham P.L.C. | Pyrimidine-4-one derivatives as ldl-pla2 inhibitors |
GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0024807D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0119793D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel compounds |
GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
GB0127143D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0127141D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham Plc | Novel compounds |
GB0127140D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
GB0208280D0 (en) * | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
WO2005003118A1 (de) | 2003-07-02 | 2005-01-13 | Bayer Healthcare Ag | Amid-substituierte 1,2,4-triazin-5 (2h)-one zur behandlung von chronisch inflammatorischen krankheiten |
DE102004061009A1 (de) | 2004-12-18 | 2006-06-22 | Bayer Healthcare Ag | Substituierte 1,2,4-Triazin-5(2H)-one |
DE102004061008A1 (de) | 2004-12-18 | 2006-06-22 | Bayer Healthcare Ag | 3-Arylalkyl- und 3-Heteroarylalkyl-substituierte 1,2,4-Triazin-5(2H)-one |
US7705005B2 (en) | 2006-10-13 | 2010-04-27 | Glaxo Group Limited | Bicyclic heteroaromatic compounds |
US20080090852A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
WO2008048867A2 (en) | 2006-10-13 | 2008-04-24 | Glaxo Group Limited | Bicyclic heteroaromatic compounds |
US20080090851A1 (en) | 2006-10-13 | 2008-04-17 | Colin Andrew Leach | Bicyclic Heteroaromatic Compounds |
WO2008141176A1 (en) | 2007-05-11 | 2008-11-20 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
US8962633B2 (en) | 2007-05-11 | 2015-02-24 | Thomas Jefferson University | Methods of treatment and prevention of metabolic bone diseases and disorders |
US20080279846A1 (en) | 2007-05-11 | 2008-11-13 | Thomas Jefferson University | Methods of treatment and prevention of neurodegenerative diseases and disorders |
US8022057B2 (en) * | 2007-11-12 | 2011-09-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
JP2011088847A (ja) * | 2009-10-21 | 2011-05-06 | Takeda Chem Ind Ltd | 三環性化合物およびその用途 |
RU2014107486A (ru) * | 2011-07-27 | 2015-09-10 | Глэксо Груп Лимитед | Бициклические пиримидоновые соединения |
-
2012
- 2012-07-25 RU RU2014107486/04A patent/RU2014107486A/ru not_active Application Discontinuation
- 2012-07-25 TW TW101126715A patent/TW201321382A/zh unknown
- 2012-07-25 AR ARP120102692A patent/AR087309A1/es not_active Application Discontinuation
- 2012-07-25 UY UY0001034216A patent/UY34216A/es unknown
- 2012-07-25 JP JP2014522075A patent/JP2014521625A/ja not_active Ceased
- 2012-07-25 EP EP12738465.9A patent/EP2736908A1/en not_active Withdrawn
- 2012-07-25 US US14/234,687 patent/US9273054B2/en not_active Expired - Fee Related
- 2012-07-25 BR BR112014001634A patent/BR112014001634A2/pt not_active IP Right Cessation
- 2012-07-25 US US13/557,498 patent/US20130030012A1/en not_active Abandoned
- 2012-07-25 WO PCT/EP2012/064598 patent/WO2013014185A1/en active Application Filing
- 2012-07-25 AU AU2012288865A patent/AU2012288865B2/en not_active Ceased
- 2012-07-25 KR KR1020147004716A patent/KR20140059204A/ko not_active Application Discontinuation
- 2012-07-25 CA CA2843102A patent/CA2843102A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2013014185A1 (en) | 2013-01-31 |
JP2014521625A (ja) | 2014-08-28 |
AU2012288865A1 (en) | 2014-02-13 |
RU2014107486A (ru) | 2015-09-10 |
AR087309A1 (es) | 2014-03-12 |
UY34216A (es) | 2013-02-28 |
CA2843102A1 (en) | 2013-01-31 |
US9273054B2 (en) | 2016-03-01 |
AU2012288865B2 (en) | 2015-10-01 |
US20140179716A1 (en) | 2014-06-26 |
US20130030012A1 (en) | 2013-01-31 |
EP2736908A1 (en) | 2014-06-04 |
KR20140059204A (ko) | 2014-05-15 |
TW201321382A (zh) | 2013-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: dismissal - article 86 of industrial property law | ||
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |