BR112013026199A2 - polipeptídeo isolado, proteína de fusão, sequência de ácidos nucleicos, vetor de expressão ou um vírus, célula recombinante, método de produção de um polipeptídeo com ectodomínio solúvel lsr, ou seu fragmento ou proteína de fusão, composição farmacêutica, uso de um anticorpo monoclonal ou policlonal ou um seu fragmento de ligação ao antígeno, uso do anticorpo ou do fragmento de ligação ao antígeno, uso de qualquer um de um polipeptídeo isolado, método de regulação por cima de citocinas, indução da expansão de células t, promoção da imunidade de células t específica antigênica e promoção da ativação das células t cd4+ e/ou cd8+ em um sujeito, método para potenciação de uma resposta imune secundária a um antígeno em um paciente, método de uso de pelo menos um de: um polipeptídeo isolado, método para tratamento ou prevenção de uma condição relacionada com o sistema imune, método para tratamento ou prevenção de uma doença infecciosa, método para diagnóstico de uma doença em um sujeito, método de produção de um polipeptídeo com ectodomínio solúvel tmem25, vsig10, ly6g6f, ou seu fragmento ou proteína de fusão, anticorpo monoclonal ou policlonal ou um seu fragmento de ligação ao antígeno, método de imunoterapia em um paciente e método para combinação de vacinação terapêutica com um antígeno em conjunto com a administração de qualquer um de um polipeptídeo - Google Patents
polipeptídeo isolado, proteína de fusão, sequência de ácidos nucleicos, vetor de expressão ou um vírus, célula recombinante, método de produção de um polipeptídeo com ectodomínio solúvel lsr, ou seu fragmento ou proteína de fusão, composição farmacêutica, uso de um anticorpo monoclonal ou policlonal ou um seu fragmento de ligação ao antígeno, uso do anticorpo ou do fragmento de ligação ao antígeno, uso de qualquer um de um polipeptídeo isolado, método de regulação por cima de citocinas, indução da expansão de células t, promoção da imunidade de células t específica antigênica e promoção da ativação das células t cd4+ e/ou cd8+ em um sujeito, método para potenciação de uma resposta imune secundária a um antígeno em um paciente, método de uso de pelo menos um de: um polipeptídeo isolado, método para tratamento ou prevenção de uma condição relacionada com o sistema imune, método para tratamento ou prevenção de uma doença infecciosa, método para diagnóstico de uma doença em um sujeito, método de produção de um polipeptídeo com ectodomínio solúvel tmem25, vsig10, ly6g6f, ou seu fragmento ou proteína de fusão, anticorpo monoclonal ou policlonal ou um seu fragmento de ligação ao antígeno, método de imunoterapia em um paciente e método para combinação de vacinação terapêutica com um antígeno em conjunto com a administração de qualquer um de um polipeptídeoInfo
- Publication number
- BR112013026199A2 BR112013026199A2 BR112013026199A BR112013026199A BR112013026199A2 BR 112013026199 A2 BR112013026199 A2 BR 112013026199A2 BR 112013026199 A BR112013026199 A BR 112013026199A BR 112013026199 A BR112013026199 A BR 112013026199A BR 112013026199 A2 BR112013026199 A2 BR 112013026199A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- polypeptide
- fusion protein
- fragment
- binding fragment
- Prior art date
Links
- 238000000034 method Methods 0.000 title 9
- 239000000427 antigen Substances 0.000 title 6
- 102000036639 antigens Human genes 0.000 title 6
- 108091007433 antigens Proteins 0.000 title 6
- 229920001184 polypeptide Polymers 0.000 title 6
- 102000004196 processed proteins & peptides Human genes 0.000 title 6
- 108090000765 processed proteins & peptides Proteins 0.000 title 6
- 239000012634 fragment Substances 0.000 title 5
- 108020001507 fusion proteins Proteins 0.000 title 3
- 102000037865 fusion proteins Human genes 0.000 title 3
- 208000035473 Communicable disease Diseases 0.000 title 1
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 230000006044 T cell activation Effects 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 230000007969 cellular immunity Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 210000000987 immune system Anatomy 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- -1 ly6g6f Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 101150091853 vsig10 gene Proteins 0.000 title 1
Classifications
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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RU2013147915A (ru) | 2015-07-20 |
AU2016222519B2 (en) | 2017-09-28 |
MX2013011978A (es) | 2015-06-10 |
AU2012241373A1 (en) | 2013-10-24 |
WO2012140627A1 (en) | 2012-10-18 |
US20160347816A1 (en) | 2016-12-01 |
NZ616344A (en) | 2015-11-27 |
RU2623161C2 (ru) | 2017-06-22 |
CN103596974A (zh) | 2014-02-19 |
RU2016147206A (ru) | 2018-10-19 |
JP2014517685A (ja) | 2014-07-24 |
CN103596974B (zh) | 2016-08-31 |
JP2017200908A (ja) | 2017-11-09 |
SG194099A1 (en) | 2013-11-29 |
CA2830923A1 (en) | 2012-10-18 |
WO2012140627A4 (en) | 2013-01-31 |
IL249810A0 (en) | 2017-02-28 |
NZ713461A (en) | 2017-02-24 |
CN105601741A (zh) | 2016-05-25 |
US9409987B2 (en) | 2016-08-09 |
ZA201509074B (en) | 2017-11-29 |
EP2697256A1 (en) | 2014-02-19 |
US20140044641A1 (en) | 2014-02-13 |
US20180194829A1 (en) | 2018-07-12 |
SG10201603034TA (en) | 2016-05-30 |
US20220048972A1 (en) | 2022-02-17 |
KR20140029446A (ko) | 2014-03-10 |
AU2016222519A1 (en) | 2016-10-06 |
IL228848A0 (en) | 2013-12-31 |
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