BR112013024899A2 - derivados de 3-ureidoisoquinolin-8-ila - Google Patents
derivados de 3-ureidoisoquinolin-8-ilaInfo
- Publication number
- BR112013024899A2 BR112013024899A2 BR112013024899A BR112013024899A BR112013024899A2 BR 112013024899 A2 BR112013024899 A2 BR 112013024899A2 BR 112013024899 A BR112013024899 A BR 112013024899A BR 112013024899 A BR112013024899 A BR 112013024899A BR 112013024899 A2 BR112013024899 A2 BR 112013024899A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- alkoxy
- ureidoisoquinolin
- derivatives
- oxopyrrolidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051320 | 2011-03-29 | ||
| IB2011054063 | 2011-09-16 | ||
| PCT/IB2012/051473 WO2012131588A1 (en) | 2011-03-29 | 2012-03-28 | 3-ureidoisoquinolin-8-yl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013024899A2 true BR112013024899A2 (pt) | 2016-12-20 |
Family
ID=45976978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013024899A BR112013024899A2 (pt) | 2011-03-29 | 2012-03-28 | derivados de 3-ureidoisoquinolin-8-ila |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8889676B2 (es) |
| EP (1) | EP2691373A1 (es) |
| JP (1) | JP2014512352A (es) |
| KR (1) | KR20140019423A (es) |
| CN (1) | CN103476756A (es) |
| AR (1) | AR088729A1 (es) |
| AU (1) | AU2012235706A1 (es) |
| BR (1) | BR112013024899A2 (es) |
| CA (1) | CA2828423A1 (es) |
| IL (1) | IL228486A0 (es) |
| MA (1) | MA35048B1 (es) |
| MX (1) | MX2013011253A (es) |
| RU (1) | RU2013147875A (es) |
| TW (1) | TW201249801A (es) |
| WO (1) | WO2012131588A1 (es) |
| ZA (1) | ZA201308049B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210070747A1 (en) | 2017-03-24 | 2021-03-11 | Taisho Pharmaceutical Co., Ltd. | 2(1h)-quinolinone derivative |
| KR20220127839A (ko) | 2019-12-24 | 2022-09-20 | 항저우 종메이화동 파마슈티칼 컴퍼니 리미티드 | Khk 억제 효과를 갖는 화합물 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| ES2251395T3 (es) | 1999-07-26 | 2006-05-01 | Banyu Pharmaceutical Co., Ltd. | Derivados de biarilureas. |
| PE20010635A1 (es) * | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
| MXPA03005298A (es) | 2000-12-15 | 2003-10-06 | Vertex Pharma | Inhibidores de girasa y usos de los mismos. |
| US6831068B2 (en) | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| PL374191A1 (en) * | 2002-06-13 | 2005-10-03 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections |
| US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| JP2007529496A (ja) | 2004-03-19 | 2007-10-25 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌剤としてのイミダゾピリジン及びイミダゾピリミジン誘導体 |
| US7524860B2 (en) | 2004-10-07 | 2009-04-28 | Pfizer Inc. | Antibacterial agents |
| US20090239841A1 (en) | 2004-10-27 | 2009-09-24 | Hutchison Alan J | Diaryl Ureas as CB1 Antagonists |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| CN1958568B (zh) * | 2005-11-03 | 2011-04-13 | 中国科学院上海药物研究所 | 一类预防或治疗幽门螺杆菌感染化合物、其制法和用途 |
| EP1948635A1 (en) | 2005-11-07 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Benzimidazole derivatives as gyrase inhibitors |
| JP2009535393A (ja) | 2006-05-01 | 2009-10-01 | ファイザー・プロダクツ・インク | 置換２−アミノ縮合複素環式化合物 |
| WO2007146230A2 (en) * | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
| RU2469034C2 (ru) | 2006-12-04 | 2012-12-10 | Астразенека Аб | Химические соединения |
| JP5178738B2 (ja) | 2006-12-20 | 2013-04-10 | メルク・シャープ・アンド・ドーム・コーポレーション | 新規なｊｎｋ阻害剤 |
| WO2008141010A2 (en) * | 2007-05-11 | 2008-11-20 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| WO2009027732A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | 5-6-bicyclic heteroaromatic compounds with antibacterial activity |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| EP2240450A1 (en) | 2008-01-04 | 2010-10-20 | Abbott Laboratories | Trpa1 antagonists |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| JP5599783B2 (ja) | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| US8283361B2 (en) | 2008-06-04 | 2012-10-09 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| TW201002728A (en) | 2008-06-04 | 2010-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| AU2009254928A1 (en) | 2008-06-04 | 2009-12-10 | Astrazeneca Ab | Thiazolo [5, 4-B] pyridine and oxazolo [5, 4-B] pyridine derivatives as antibacterial agents |
| US20110166088A1 (en) | 2008-06-25 | 2011-07-07 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| WO2010142978A1 (en) | 2009-06-08 | 2010-12-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| TW201111380A (en) | 2009-08-26 | 2011-04-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| EP2552893B1 (en) | 2010-03-31 | 2014-10-29 | Actelion Pharmaceuticals Ltd. | Antibacterial isoquinolin-3-ylurea derivatives |
-
2012
- 2012-03-27 AR ARP120101017A patent/AR088729A1/es not_active Application Discontinuation
- 2012-03-28 KR KR1020137028588A patent/KR20140019423A/ko not_active Application Discontinuation
- 2012-03-28 US US14/009,093 patent/US8889676B2/en not_active Expired - Fee Related
- 2012-03-28 BR BR112013024899A patent/BR112013024899A2/pt not_active IP Right Cessation
- 2012-03-28 MA MA36339A patent/MA35048B1/fr unknown
- 2012-03-28 TW TW101110929A patent/TW201249801A/zh unknown
- 2012-03-28 MX MX2013011253A patent/MX2013011253A/es not_active Application Discontinuation
- 2012-03-28 CA CA2828423A patent/CA2828423A1/en not_active Abandoned
- 2012-03-28 CN CN2012800151068A patent/CN103476756A/zh active Pending
- 2012-03-28 AU AU2012235706A patent/AU2012235706A1/en not_active Abandoned
- 2012-03-28 RU RU2013147875/04A patent/RU2013147875A/ru not_active Application Discontinuation
- 2012-03-28 EP EP12715438.3A patent/EP2691373A1/en not_active Withdrawn
- 2012-03-28 JP JP2014501786A patent/JP2014512352A/ja active Pending
- 2012-03-28 WO PCT/IB2012/051473 patent/WO2012131588A1/en active Application Filing
-
2013
- 2013-09-17 IL IL228486A patent/IL228486A0/en unknown
- 2013-10-29 ZA ZA2013/08049A patent/ZA201308049B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201308049B (en) | 2016-08-31 |
| TW201249801A (en) | 2012-12-16 |
| JP2014512352A (ja) | 2014-05-22 |
| IL228486A0 (en) | 2013-12-31 |
| CA2828423A1 (en) | 2012-10-04 |
| CN103476756A (zh) | 2013-12-25 |
| EP2691373A1 (en) | 2014-02-05 |
| KR20140019423A (ko) | 2014-02-14 |
| WO2012131588A1 (en) | 2012-10-04 |
| AU2012235706A1 (en) | 2013-11-14 |
| US20140038961A1 (en) | 2014-02-06 |
| AR088729A1 (es) | 2014-07-02 |
| MA35048B1 (fr) | 2014-04-03 |
| NZ617068A (en) | 2015-05-29 |
| MX2013011253A (es) | 2013-10-17 |
| US8889676B2 (en) | 2014-11-18 |
| RU2013147875A (ru) | 2015-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |