BR112013024899A2 - derivados de 3-ureidoisoquinolin-8-ila - Google Patents
derivados de 3-ureidoisoquinolin-8-ilaInfo
- Publication number
- BR112013024899A2 BR112013024899A2 BR112013024899A BR112013024899A BR112013024899A2 BR 112013024899 A2 BR112013024899 A2 BR 112013024899A2 BR 112013024899 A BR112013024899 A BR 112013024899A BR 112013024899 A BR112013024899 A BR 112013024899A BR 112013024899 A2 BR112013024899 A2 BR 112013024899A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- alkoxy
- ureidoisoquinolin
- derivatives
- oxopyrrolidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
derivados de 3-ureidoisoquinolin-8-ila a presente invenção refere-se a derivados de 3-ureidoisoquinolin-8-ila de fórmula i em que r^ 1^ é alquila, haloalquila ou ciclopropila; r^ 2^ é h, halogênio, piridazin-4-ila, pirimidin-5-ila ou um grupo piridin-3-ila, piridin-4-ila ou fenila opcionalmente substituído; r^ 3^ é alquila, alquinila, aminalquila, carbomoilalquila, metilcarbamoilalquila, alcoxi, haloalcoxi, alquiniloxi, (4-hidroxibut-2-in-1-il)oxi, (4-aminabut-2-in-1-il)oxi, dimetilamin alcoxi, carbamoil alcoxi, alquilamina, cicloaalquila, cicloalquil alquila, cicloalquilalcoxi, hidroxialquila, hidroxialcoxi, alcoxi alquila, alcoxialcoxix carvoxialquila, carboxialcoxi, alcoxicarbonil alcoxi, arila, heteroarila, benzila, benziloxi, 2-cianoetoxi, 2,3-dihidroxipropoxi, 3,4-dihidroxibutoxi, -ch~ 2~r^ a^, -ch~ 2~ch~ 2~r^ b^, -(ch~ 2~)~ n~-c(o)o-r^ ~d^, -(ch~ 2~)~ n~-n(r^ c^)c(o)o-r^ d^, -o-(ch~ 2~)~ n~-n(r^ c^)c(o)o-r^ d^, -(ch~ 2~)~ n~-r^ e^ ou -o- (ch~ 2~)~ n~-r^ e^; r^ a^ é ciano, acetilamina ou n,n-dimetilamina; r^ b^ é ciano ou carbamoila; r^ c^ é h ou metila; r^ d^ é alquila; r^ e^ é pirrolidin-1-ila, piperidin-1-ila, piperidin-3-ila, morfolin-1-ila, 2-oxopirrolidin-1-ila, 5-oxopirrolidin-2-ila, 2,5-dioxopirrolidin-1-ila, 2-oxoimidazolidin-1-ila, 4-(terc-butoxicarbonila)piperazin-1-ila, 4-(aminometila)ciclohexila ou heterioarila; r^ 4^ é h ou metila; e aos sais de tais compostos. estes compostos são úteis para a prevenção ou o tratamento de infecções bacterianas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051320 | 2011-03-29 | ||
| IB2011054063 | 2011-09-16 | ||
| PCT/IB2012/051473 WO2012131588A1 (en) | 2011-03-29 | 2012-03-28 | 3-ureidoisoquinolin-8-yl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013024899A2 true BR112013024899A2 (pt) | 2016-12-20 |
Family
ID=45976978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013024899A BR112013024899A2 (pt) | 2011-03-29 | 2012-03-28 | derivados de 3-ureidoisoquinolin-8-ila |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8889676B2 (pt) |
| EP (1) | EP2691373A1 (pt) |
| JP (1) | JP2014512352A (pt) |
| KR (1) | KR20140019423A (pt) |
| CN (1) | CN103476756A (pt) |
| AR (1) | AR088729A1 (pt) |
| AU (1) | AU2012235706A1 (pt) |
| BR (1) | BR112013024899A2 (pt) |
| CA (1) | CA2828423A1 (pt) |
| IL (1) | IL228486A0 (pt) |
| MA (1) | MA35048B1 (pt) |
| MX (1) | MX2013011253A (pt) |
| RU (1) | RU2013147875A (pt) |
| TW (1) | TW201249801A (pt) |
| WO (1) | WO2012131588A1 (pt) |
| ZA (1) | ZA201308049B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2018174288A1 (ja) | 2017-03-24 | 2020-01-23 | 大正製薬株式会社 | ２（１ｈ）−キノリノン誘導体 |
| WO2021129737A1 (zh) | 2019-12-24 | 2021-07-01 | 南京明德新药研发有限公司 | 具有khk抑制作用的化合物 |
Family Cites Families (38)
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| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| DE60024631T2 (de) | 1999-07-26 | 2006-06-14 | Banyu Pharma Co Ltd | Biaryl-harnstoff-derivate |
| US6846819B1 (en) * | 1999-10-08 | 2005-01-25 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| EP1341769B1 (en) | 2000-12-15 | 2007-10-17 | Vertex Pharmaceuticals Incorporated | Bacterial gyrase inhibitors and uses thereof |
| US6831068B2 (en) | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| KR101052433B1 (ko) | 2002-06-13 | 2011-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 자이라제 및/또는 토포이소머라제 ⅳ 억제제로서의 2-우레이도-6-헤테로아릴-3ｈ-벤조이미다졸-4-카복실산 유도체 및 이를 포함하는 세균 감염 치료용 약제학적 조성물 |
| US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| JP2007529496A (ja) | 2004-03-19 | 2007-10-25 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌剤としてのイミダゾピリジン及びイミダゾピリミジン誘導体 |
| BRPI0516819A (pt) | 2004-10-07 | 2008-09-23 | Warner Lambert Co | derivados de triazolopiridina e agentes antibacterianos |
| CA2575764A1 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as cb1 antagonists |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| CN1958568B (zh) | 2005-11-03 | 2011-04-13 | 中国科学院上海药物研究所 | 一类预防或治疗幽门螺杆菌感染化合物、其制法和用途 |
| US8394803B2 (en) | 2005-11-07 | 2013-03-12 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| JP2009535393A (ja) | 2006-05-01 | 2009-10-01 | ファイザー・プロダクツ・インク | 置換２−アミノ縮合複素環式化合物 |
| WO2007146230A2 (en) * | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
| ES2363178T3 (es) | 2006-12-04 | 2011-07-26 | Astrazeneca Ab | Compuestos de urea policíclicos antibacterianos. |
| WO2008082487A2 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
| EP2155775A2 (en) | 2007-05-11 | 2010-02-24 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| WO2009027732A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | 5-6-bicyclic heteroaromatic compounds with antibacterial activity |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| US8877784B2 (en) | 2008-01-04 | 2014-11-04 | Abbvie Inc. | TRPA1 antagonists |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
| JP2011522026A (ja) | 2008-06-04 | 2011-07-28 | アストラゼネカ アクチボラグ | 細菌感染の処置用の複素環式尿素誘導体 |
| AU2009254928A1 (en) | 2008-06-04 | 2009-12-10 | Astrazeneca Ab | Thiazolo [5, 4-B] pyridine and oxazolo [5, 4-B] pyridine derivatives as antibacterial agents |
| CL2009001345A1 (es) | 2008-06-04 | 2010-06-11 | Astrazeneca Ab | Compuestos derivados de 1-piridin-2-il-urea y 1-pirimidin-2-il-urea sustituidos, inhibidores de adn girasa y topoisomerasa iv; composicion farmaceutica; y su uso en tratamiento de infecciones bacterianas como neumonia adquirida intrahospitalariamente, infecciones a la piel, bronquitis, sinusitis, entre otras enfermedades. |
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| TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
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| CA2793975A1 (en) | 2010-03-31 | 2011-10-10 | Actelion Pharmaceuticals Ltd | Antibacterial isoquinolin-3-ylurea derivatives |
-
2012
- 2012-03-27 AR ARP120101017A patent/AR088729A1/es not_active Application Discontinuation
- 2012-03-28 AU AU2012235706A patent/AU2012235706A1/en not_active Abandoned
- 2012-03-28 CA CA2828423A patent/CA2828423A1/en not_active Abandoned
- 2012-03-28 RU RU2013147875/04A patent/RU2013147875A/ru not_active Application Discontinuation
- 2012-03-28 BR BR112013024899A patent/BR112013024899A2/pt not_active IP Right Cessation
- 2012-03-28 MA MA36339A patent/MA35048B1/fr unknown
- 2012-03-28 US US14/009,093 patent/US8889676B2/en not_active Expired - Fee Related
- 2012-03-28 MX MX2013011253A patent/MX2013011253A/es not_active Application Discontinuation
- 2012-03-28 JP JP2014501786A patent/JP2014512352A/ja active Pending
- 2012-03-28 EP EP12715438.3A patent/EP2691373A1/en not_active Withdrawn
- 2012-03-28 CN CN2012800151068A patent/CN103476756A/zh active Pending
- 2012-03-28 TW TW101110929A patent/TW201249801A/zh unknown
- 2012-03-28 KR KR1020137028588A patent/KR20140019423A/ko not_active Application Discontinuation
- 2012-03-28 WO PCT/IB2012/051473 patent/WO2012131588A1/en active Application Filing
-
2013
- 2013-09-17 IL IL228486A patent/IL228486A0/en unknown
- 2013-10-29 ZA ZA2013/08049A patent/ZA201308049B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR088729A1 (es) | 2014-07-02 |
| WO2012131588A1 (en) | 2012-10-04 |
| US20140038961A1 (en) | 2014-02-06 |
| EP2691373A1 (en) | 2014-02-05 |
| CA2828423A1 (en) | 2012-10-04 |
| JP2014512352A (ja) | 2014-05-22 |
| MA35048B1 (fr) | 2014-04-03 |
| US8889676B2 (en) | 2014-11-18 |
| KR20140019423A (ko) | 2014-02-14 |
| MX2013011253A (es) | 2013-10-17 |
| TW201249801A (en) | 2012-12-16 |
| AU2012235706A1 (en) | 2013-11-14 |
| ZA201308049B (en) | 2016-08-31 |
| RU2013147875A (ru) | 2015-05-10 |
| NZ617068A (en) | 2015-05-29 |
| CN103476756A (zh) | 2013-12-25 |
| IL228486A0 (en) | 2013-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |