BR112013018875A2 - métodos e composições para a preparação de noribogaína a partir de voacangina - Google Patents
métodos e composições para a preparação de noribogaína a partir de voacanginaInfo
- Publication number
- BR112013018875A2 BR112013018875A2 BR112013018875A BR112013018875A BR112013018875A2 BR 112013018875 A2 BR112013018875 A2 BR 112013018875A2 BR 112013018875 A BR112013018875 A BR 112013018875A BR 112013018875 A BR112013018875 A BR 112013018875A BR 112013018875 A2 BR112013018875 A2 BR 112013018875A2
- Authority
- BR
- Brazil
- Prior art keywords
- voacangin
- noribogain
- compositions
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161436511P | 2011-01-26 | 2011-01-26 | |
| US201161453884P | 2011-03-17 | 2011-03-17 | |
| US201161454904P | 2011-03-21 | 2011-03-21 | |
| PCT/US2012/022255 WO2012103028A2 (en) | 2011-01-26 | 2012-01-23 | Methods and compositions for preparing noribogaine from voacangine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013018875A2 true BR112013018875A2 (pt) | 2017-01-31 |
Family
ID=43977940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013018875A BR112013018875A2 (pt) | 2011-01-26 | 2012-01-23 | métodos e composições para a preparação de noribogaína a partir de voacangina |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8859764B2 (pt) |
| EP (1) | EP2481740B1 (pt) |
| JP (2) | JP6093310B2 (pt) |
| KR (2) | KR102076464B1 (pt) |
| AU (1) | AU2012209332B2 (pt) |
| BR (1) | BR112013018875A2 (pt) |
| CA (1) | CA2825298C (pt) |
| IL (1) | IL227593A (pt) |
| MX (1) | MX2013008572A (pt) |
| RU (1) | RU2592698C2 (pt) |
| SG (1) | SG192099A1 (pt) |
| UA (1) | UA111186C2 (pt) |
| WO (1) | WO2012103028A2 (pt) |
| ZA (1) | ZA201306316B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| KR102381792B1 (ko) * | 2011-09-15 | 2022-04-01 | 데메알엑스, 인크. | 노르이보가인 염 무용매화물 |
| CA2855994A1 (en) | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| AU2013212139A1 (en) | 2012-01-25 | 2014-06-26 | Demerx, Inc. | Synthetic voacangine |
| WO2014098877A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| CA2942638A1 (en) | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| JP2017509612A (ja) | 2014-02-18 | 2017-04-06 | デメルクス，インコーポレイテッド | 薬物中毒の急性および長期間での治療方法。 |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| US9345711B2 (en) | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| ES2955490T3 (es) | 2014-11-26 | 2023-12-01 | Demerx Inc | Métodos y composiciones para potenciar la acción de los analgésicos opioides mediante el uso de alcaloides de la iboga |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CN114206349A (zh) | 2019-04-17 | 2022-03-18 | 指南针探路者有限公司 | 治疗神经认知障碍、慢性疼痛及减轻炎症的方法 |
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| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| RU2586296C2 (ru) * | 2010-07-23 | 2016-06-10 | Демеркс, Инк. | Композиции норибогаина |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US8742096B2 (en) | 2011-03-28 | 2014-06-03 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| KR102381792B1 (ko) | 2011-09-15 | 2022-04-01 | 데메알엑스, 인크. | 노르이보가인 염 무용매화물 |
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| IN2014CN04160A (pt) | 2011-12-08 | 2015-07-17 | Demerx Inc | |
| CA2855994A1 (en) | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
| AU2013239995A1 (en) | 2012-03-27 | 2014-11-06 | Albany Medical College | Blocking of cue-induced drug reinstatement |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
-
2011
- 2011-03-24 EP EP11159572.4A patent/EP2481740B1/en active Active
-
2012
- 2012-01-23 UA UAA201310100A patent/UA111186C2/uk unknown
- 2012-01-23 RU RU2013139382/04A patent/RU2592698C2/ru not_active IP Right Cessation
- 2012-01-23 CA CA2825298A patent/CA2825298C/en active Active
- 2012-01-23 WO PCT/US2012/022255 patent/WO2012103028A2/en active Application Filing
- 2012-01-23 BR BR112013018875A patent/BR112013018875A2/pt not_active IP Right Cessation
- 2012-01-23 KR KR1020197021252A patent/KR102076464B1/ko active IP Right Grant
- 2012-01-23 US US13/496,185 patent/US8859764B2/en active Active
- 2012-01-23 KR KR1020137022370A patent/KR20140022000A/ko not_active Application Discontinuation
- 2012-01-23 JP JP2013551265A patent/JP6093310B2/ja active Active
- 2012-01-23 MX MX2013008572A patent/MX2013008572A/es unknown
- 2012-01-23 SG SG2013056130A patent/SG192099A1/en unknown
- 2012-01-23 AU AU2012209332A patent/AU2012209332B2/en not_active Ceased
-
2013
- 2013-07-22 IL IL227593A patent/IL227593A/en not_active IP Right Cessation
- 2013-08-21 ZA ZA2013/06316A patent/ZA201306316B/en unknown
-
2014
- 2014-10-14 US US14/514,307 patent/US9403817B2/en active Active
-
2016
- 2016-11-02 JP JP2016214906A patent/JP2017061492A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ614366A (en) | 2015-11-27 |
| WO2012103028A2 (en) | 2012-08-02 |
| US9403817B2 (en) | 2016-08-02 |
| SG192099A1 (en) | 2013-08-30 |
| KR20140022000A (ko) | 2014-02-21 |
| KR20190089228A (ko) | 2019-07-30 |
| CA2825298C (en) | 2020-03-31 |
| RU2592698C2 (ru) | 2016-07-27 |
| AU2012209332A8 (en) | 2013-09-12 |
| JP2014503584A (ja) | 2014-02-13 |
| AU2012209332B2 (en) | 2017-03-02 |
| WO2012103028A3 (en) | 2012-12-06 |
| US20150133655A1 (en) | 2015-05-14 |
| JP2017061492A (ja) | 2017-03-30 |
| EP2481740B1 (en) | 2015-11-04 |
| US20130303756A1 (en) | 2013-11-14 |
| ZA201306316B (en) | 2014-04-30 |
| RU2013139382A (ru) | 2015-03-10 |
| EP2481740A1 (en) | 2012-08-01 |
| US8859764B2 (en) | 2014-10-14 |
| MX2013008572A (es) | 2013-09-26 |
| CA2825298A1 (en) | 2012-08-02 |
| IL227593A (en) | 2016-11-30 |
| KR102076464B1 (ko) | 2020-02-11 |
| IL227593A0 (en) | 2013-09-30 |
| UA111186C2 (uk) | 2016-04-11 |
| JP6093310B2 (ja) | 2017-03-08 |
| AU2012209332A1 (en) | 2013-09-05 |
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