DK0804200T3 - Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr - Google Patents
Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyrInfo
- Publication number
- DK0804200T3 DK0804200T3 DK95927295T DK95927295T DK0804200T3 DK 0804200 T3 DK0804200 T3 DK 0804200T3 DK 95927295 T DK95927295 T DK 95927295T DK 95927295 T DK95927295 T DK 95927295T DK 0804200 T3 DK0804200 T3 DK 0804200T3
- Authority
- DK
- Denmark
- Prior art keywords
- noribogain
- mammals
- derivatives
- treatment
- chemical dependence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28018794A | 1994-07-25 | 1994-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0804200T3 true DK0804200T3 (da) | 2006-09-11 |
Family
ID=23072046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95927295T DK0804200T3 (da) | 1994-07-25 | 1995-07-25 | Anvendelse af noribogain-derivater til behandling af kemisk afhængighed hos pattedyr |
Country Status (11)
Country | Link |
---|---|
US (1) | US6348456B1 (da) |
EP (1) | EP0804200B1 (da) |
AT (1) | ATE324897T1 (da) |
AU (1) | AU4613296A (da) |
DE (1) | DE69534975T2 (da) |
DK (1) | DK0804200T3 (da) |
ES (1) | ES2264562T3 (da) |
IL (1) | IL114726A (da) |
MX (1) | MX9701430A (da) |
PT (1) | PT804200E (da) |
WO (1) | WO1996003127A1 (da) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
ATE265213T1 (de) * | 1997-09-04 | 2004-05-15 | Novoneuron Inc | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
AU2003200404B2 (en) * | 1997-09-04 | 2006-06-29 | Demerx, Inc. | Noribogaine in the treatment of pain and drug addiction |
BR0106261A (pt) * | 2001-12-26 | 2003-09-02 | Fundacao Oswaldo Cruz | Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids |
US20030153552A1 (en) * | 2002-02-14 | 2003-08-14 | Mash Deborah C. | Method of treating chemical dependency in mammals and a composition therefor |
GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
RU2586296C2 (ru) * | 2010-07-23 | 2016-06-10 | Демеркс, Инк. | Композиции норибогаина |
AU2012202509B2 (en) * | 2010-07-23 | 2014-02-13 | Demerx, Inc. | Noribogaine compositions |
EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
CA2845007C (en) | 2011-09-15 | 2020-09-29 | Demerx, Inc. | Ansolvate or crystalline polymorph noribogaine salts |
EP2788355A4 (en) | 2011-12-08 | 2015-10-21 | Demerx Inc | STEREOSELECTIVE TOTAL SYNTHESIS OF NORIBOGAIN |
EP2788003A4 (en) * | 2011-12-09 | 2015-05-27 | Demerx Inc | PHOSPHATESTER OF NORIBOGAIN |
WO2013085849A2 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Sulfate esters of noribogaine |
US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
WO2013112163A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
CA2942638A1 (en) * | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
EP3096794A2 (en) * | 2014-01-24 | 2016-11-30 | DemeRx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US9345711B2 (en) | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
KR20160124829A (ko) * | 2014-02-18 | 2016-10-28 | 데메알엑스, 인크. | 노르이보가인 및 관련된 화합물을 이용하는 치료 방법 |
JP2017509612A (ja) | 2014-02-18 | 2017-04-06 | デメルクス,インコーポレイテッド | 薬物中毒の急性および長期間での治療方法。 |
US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
WO2016086194A1 (en) | 2014-11-26 | 2016-06-02 | Demerx, Inc. | Methods and compositions for potentiating the action of opioid analgesics using iboga alkaloids |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
CN114206349A (zh) | 2019-04-17 | 2022-03-18 | 指南针探路者有限公司 | 治疗神经认知障碍、慢性疼痛及减轻炎症的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3516989A (en) * | 1967-10-02 | 1970-06-23 | American Home Prod | Intermediates for total synthesis of iboga alkaloids and means of preparation |
US4499096A (en) * | 1983-11-18 | 1985-02-12 | Lotsof Howard S | Rapid method for interrupting the narcotic addiction syndrome |
US4587243A (en) * | 1985-07-15 | 1986-05-06 | Lotsof Howard S | Rapid method for interrupting the ***e and amphetamine abuse syndrome |
US5152994A (en) * | 1990-05-31 | 1992-10-06 | Lotsof Howard S | Rapid method for interrupting or attenuating poly-drug dependency syndromes |
US5591738A (en) * | 1994-10-14 | 1997-01-07 | Nda International, Inc. | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof |
-
1995
- 1995-07-25 AT AT95927295T patent/ATE324897T1/de not_active IP Right Cessation
- 1995-07-25 PT PT95927295T patent/PT804200E/pt unknown
- 1995-07-25 DK DK95927295T patent/DK0804200T3/da active
- 1995-07-25 ES ES95927295T patent/ES2264562T3/es not_active Expired - Lifetime
- 1995-07-25 WO PCT/US1995/009136 patent/WO1996003127A1/en active IP Right Grant
- 1995-07-25 AU AU46132/96A patent/AU4613296A/en not_active Abandoned
- 1995-07-25 DE DE69534975T patent/DE69534975T2/de not_active Expired - Lifetime
- 1995-07-25 EP EP95927295A patent/EP0804200B1/en not_active Expired - Lifetime
- 1995-07-25 IL IL11472695A patent/IL114726A/en not_active IP Right Cessation
- 1995-07-25 MX MX9701430A patent/MX9701430A/es not_active IP Right Cessation
-
1996
- 1996-10-08 US US08/727,123 patent/US6348456B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2264562T3 (es) | 2007-01-01 |
US6348456B1 (en) | 2002-02-19 |
DE69534975D1 (de) | 2006-06-08 |
PT804200E (pt) | 2006-09-29 |
IL114726A (en) | 2002-04-21 |
WO1996003127A1 (en) | 1996-02-08 |
ATE324897T1 (de) | 2006-06-15 |
DE69534975T2 (de) | 2007-01-11 |
EP0804200A4 (en) | 1999-06-23 |
EP0804200B1 (en) | 2006-05-03 |
AU4613296A (en) | 1996-04-19 |
EP0804200A1 (en) | 1997-11-05 |
IL114726A0 (en) | 1995-11-27 |
MX9701430A (es) | 1997-12-31 |
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