UA112795C2 - Біциклічні піразинонові похідні - Google Patents

Біциклічні піразинонові похідні

Info

Publication number
UA112795C2
UA112795C2 UAA201411566A UAA201411566A UA112795C2 UA 112795 C2 UA112795 C2 UA 112795C2 UA A201411566 A UAA201411566 A UA A201411566A UA A201411566 A UAA201411566 A UA A201411566A UA 112795 C2 UA112795 C2 UA 112795C2
Authority
UA
Ukraine
Prior art keywords
pyrazinone derivatives
bicyclic
bicyclic pyrazinone
derivatives
tankirase
Prior art date
Application number
UAA201411566A
Other languages
English (en)
Inventor
Дітер Дорш
Ханс-Петер Бухшталлер
Жерар Муане
Ансгар Вегенер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013911&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA112795(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of UA112795C2 publication Critical patent/UA112795C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Сполуки формули І, Iв якій R, X і Υ мають значення, зазначені в п. 1, є інгібіторами танкірази і можуть застосовуватися, серед іншого, для лікування захворювань, таких як злоякісне новоутворення, серцево-судинні захворювання, ураження центральної нервової системи та різні форми запалення.
UAA201411566A 2012-03-28 2013-03-19 Біциклічні піразинонові похідні UA112795C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12002215 2012-03-28
PCT/EP2013/000827 WO2013143663A1 (en) 2012-03-28 2013-03-19 Bicyclic pyrazinone derivatives

Publications (1)

Publication Number Publication Date
UA112795C2 true UA112795C2 (uk) 2016-10-25

Family

ID=48013911

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201411566A UA112795C2 (uk) 2012-03-28 2013-03-19 Біциклічні піразинонові похідні

Country Status (32)

Country Link
US (1) US9120805B2 (uk)
EP (1) EP2831077B1 (uk)
JP (1) JP6096879B2 (uk)
KR (1) KR102070567B1 (uk)
CN (1) CN104169284B (uk)
AR (1) AR090496A1 (uk)
AU (1) AU2013242492B2 (uk)
CA (1) CA2868620C (uk)
CL (1) CL2014002557A1 (uk)
CO (1) CO7111292A2 (uk)
DK (1) DK2831077T3 (uk)
EA (1) EA027416B1 (uk)
EC (1) ECSP14024526A (uk)
ES (1) ES2585044T3 (uk)
HK (1) HK1203961A1 (uk)
HR (1) HRP20160908T1 (uk)
HU (1) HUE030067T2 (uk)
IL (1) IL234713A (uk)
MX (1) MX351149B (uk)
MY (1) MY172308A (uk)
NZ (1) NZ630489A (uk)
PE (1) PE20142186A1 (uk)
PH (1) PH12014501829A1 (uk)
PL (1) PL2831077T3 (uk)
PT (1) PT2831077T (uk)
RS (1) RS54997B1 (uk)
SG (1) SG11201405750YA (uk)
SI (1) SI2831077T1 (uk)
TW (1) TWI576346B (uk)
UA (1) UA112795C2 (uk)
WO (1) WO2013143663A1 (uk)
ZA (1) ZA201407828B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2611504T3 (es) 2012-03-07 2017-05-09 Institute Of Cancer Research: Royal Cancer Hospital (The) Compuestos de isoquinolin-1-ona 3-aril-5-sustituida y sus usos terapéuticos
AU2013242492B2 (en) 2012-03-28 2016-12-15 Merck Patent Gmbh Bicyclic pyrazinone derivatives
MX2014012477A (es) * 2012-06-20 2014-12-10 Hoffmann La Roche Inhibidores pirrolopirazona de tanquirasa.
NO3044221T3 (uk) 2013-09-11 2018-07-21
CN105829317B (zh) * 2013-12-23 2019-03-29 默克专利股份公司 咪唑并吡嗪酮衍生物
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
KR101739003B1 (ko) * 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
PL3227297T3 (pl) * 2014-12-05 2021-10-25 Array Biopharma, Inc. 4,6 podstawione-pyrazolo[1,5-a]pirazyny jako inhibitory kinaz janusowych
MX2018001871A (es) 2015-08-17 2018-05-28 Lupin Ltd Derivados de heteroarilo como inhibidores de parp.
JP6505956B2 (ja) 2016-02-24 2019-04-24 ファイザー・インク ＪＡＫ阻害剤としてのピラゾロ［１，５−ａ］ピラジン−４−イル誘導体
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
AU2019270142A1 (en) * 2018-05-17 2020-11-12 Bayer Aktiengesellschaft Substituted dihydropyrazolo pyrazine carboxamide derivatives

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
ES2194181T3 (es) 1996-02-13 2003-11-16 Astrazeneca Ab Derivados de quinazolina como inhibidores de vegf.
DK0885198T3 (da) 1996-03-05 2002-03-25 Astrazeneca Ab 4-Anilinoquinazolinderivater
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
SE9702706D0 (sv) 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
WO2001092224A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
AU6623201A (en) 2000-07-07 2002-02-05 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
AU2007266840B2 (en) * 2006-05-31 2012-09-20 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrrolo[1,2-A]pyrazin-1(2H)-one and pyrrolo[1,2-D][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase(PARP)
WO2008082887A2 (en) * 2006-12-28 2008-07-10 Abbott Laboratories Inhibitors of poly(adp-ribose)polymerase
EP2134691B1 (en) 2007-03-08 2012-01-25 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp and tank inhibitors
DE102007032349A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
WO2009130231A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists
WO2009130232A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors
JP5579724B2 (ja) 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
CA2787714C (en) 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
CN102933584A (zh) * 2010-04-16 2013-02-13 Abbvie公司 激酶的吡咯并吡嗪酮抑制剂
CN102229611B (zh) * 2011-04-26 2012-12-12 山东大学 2,6-二芳基吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其应用
AU2013242492B2 (en) 2012-03-28 2016-12-15 Merck Patent Gmbh Bicyclic pyrazinone derivatives
MX2014012477A (es) * 2012-06-20 2014-12-10 Hoffmann La Roche Inhibidores pirrolopirazona de tanquirasa.

Also Published As

Publication number Publication date
AU2013242492B2 (en) 2016-12-15
ES2585044T3 (es) 2016-10-03
CA2868620C (en) 2020-02-25
DK2831077T3 (en) 2016-08-15
AU2013242492A1 (en) 2014-11-13
IL234713A (en) 2016-09-29
PE20142186A1 (es) 2014-12-29
PT2831077T (pt) 2016-08-12
PH12014501829B1 (en) 2014-11-10
CL2014002557A1 (es) 2014-12-19
KR102070567B1 (ko) 2020-01-29
SI2831077T1 (sl) 2016-09-30
HK1203961A1 (en) 2015-11-06
PL2831077T3 (pl) 2016-10-31
RS54997B1 (sr) 2016-11-30
CN104169284B (zh) 2017-03-29
EA027416B1 (ru) 2017-07-31
EP2831077B1 (en) 2016-04-27
ZA201407828B (en) 2015-12-23
CA2868620A1 (en) 2013-10-03
MX2014011420A (es) 2014-11-25
WO2013143663A1 (en) 2013-10-03
NZ630489A (en) 2016-04-29
EA201401062A1 (ru) 2015-04-30
HRP20160908T1 (hr) 2016-09-23
PH12014501829A1 (en) 2014-11-10
MY172308A (en) 2019-11-21
AR090496A1 (es) 2014-11-19
JP2015511609A (ja) 2015-04-20
TWI576346B (zh) 2017-04-01
KR20140140099A (ko) 2014-12-08
MX351149B (es) 2017-10-04
ECSP14024526A (es) 2015-09-30
CN104169284A (zh) 2014-11-26
US9120805B2 (en) 2015-09-01
US20150057264A1 (en) 2015-02-26
EP2831077A1 (en) 2015-02-04
HUE030067T2 (en) 2017-04-28
CO7111292A2 (es) 2014-11-10
TW201343650A (zh) 2013-11-01
SG11201405750YA (en) 2014-10-30
JP6096879B2 (ja) 2017-03-15

Similar Documents

Publication Publication Date Title
UA112795C2 (uk) Біциклічні піразинонові похідні
CY1122266T1 (el) Ενωσεις 3-αμινοκυκλοαλκυλιου ως ror-gamma-t αναστολεις και χρησεις αυτων
CY1120866T1 (el) Παρεμποδιστες dna-pk
EA201401212A1 (ru) Производные пирролотриазинона
TR201901886T4 (tr) DNA-PK inhibitörleri.
UA111075C2 (uk) Триазолопіридинові сполуки як інгібітори кінази рім
MX362939B (es) Derivados de (aza-)isoquinolinona.
EA201291143A1 (ru) Пиразолилхиназолиновые ингибиторы киназы
EA201400879A1 (ru) Производные тетрагидрохиназолинона в качестве ингибиторов tank и parp
MX362215B (es) Derivados 2-aminopirido-[4,3-d]pirimidin-5-ona y su uso como inhibidores de wee-1.
MX362855B (es) Derivados de quinazolinona como inhidores poli (adp-ribosa) polimerasa (parp).
EA201691032A1 (ru) Производные изохромена в качестве ингибиторов фосфоинозитид-3-киназ
EA201500298A1 (ru) Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы
EA201301301A1 (ru) Производные тиазола
EA201590183A1 (ru) Производные азаиндола, выступающие в качестве ингибиторов pi3k
MX359656B (es) Derivados de oxoquinazolinil-butanamida.
MX2016008042A (es) Derivados de imidazopirazinona.
MX2016001134A (es) Derivados 1,3-disustituidos de ciclopentano.
EA201290744A1 (ru) Имидазо[1,2-b][1,2,4]триазины в качестве c-met ингибиторов
MX2016001536A (es) Derivados de urea de piperidinas.
EA201590656A1 (ru) Азаиндолины
EA201491026A1 (ru) Производные 3-фенилизохинолин-1(2h)-она в качестве ингибиторов parp-1
MX369393B (es) Derivados de ftalazina.
MX2016001934A (es) Derivados de ciclopentilamina 3-sustituidos.
MY159995A (en) Pyrimidinyl indole compounds