BR112013008700B8 - Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante - Google Patents

Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante

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Publication number
BR112013008700B8
BR112013008700B8 BR112013008700A BR112013008700A BR112013008700B8 BR 112013008700 B8 BR112013008700 B8 BR 112013008700B8 BR 112013008700 A BR112013008700 A BR 112013008700A BR 112013008700 A BR112013008700 A BR 112013008700A BR 112013008700 B8 BR112013008700 B8 BR 112013008700B8
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self
replicating rna
rna molecule
molecule
composition
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BR112013008700A
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English (en)
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BR112013008700A2 (pt
BR112013008700B1 (pt
Inventor
Lilja Anders
Loomis Rebecca
Franti Michael
Mason Peter
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Novartis Ag
Glaxosmithkline Biologicals Sa
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Application filed by Novartis Ag, Glaxosmithkline Biologicals Sa filed Critical Novartis Ag
Publication of BR112013008700A2 publication Critical patent/BR112013008700A2/pt
Publication of BR112013008700B1 publication Critical patent/BR112013008700B1/pt
Publication of BR112013008700B8 publication Critical patent/BR112013008700B8/pt

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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C12N15/09—Recombinant DNA-technology
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    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Epidemiology (AREA)
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  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

PLATAFORMAS DE LIBERAÇÃO DE ANTÍGENO Essa revelação fornece plataformas para a liberação de proteínas de herpesvírus às célula, particularmente proteínas que formam complexos in vivo. Em algumas modalidades, essas proteínas e os complexos que formam despertam anticorpos neutralizantes potentes. Dessa forma, a apresentação de proteínas de herpesvírus usando as plataformas reveladas permite a geração de respostas imunes amplas e potentes úteis para o desenvolvimento de vacinas,
BR112013008700A 2010-10-11 2011-10-11 Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante BR112013008700B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39196010P 2010-10-11 2010-10-11
US61/391,960 2010-10-11
PCT/US2011/055834 WO2012051211A2 (en) 2010-10-11 2011-10-11 Antigen delivery platforms

Publications (3)

Publication Number Publication Date
BR112013008700A2 BR112013008700A2 (pt) 2016-06-21
BR112013008700B1 BR112013008700B1 (pt) 2021-03-02
BR112013008700B8 true BR112013008700B8 (pt) 2022-10-04

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BR112013008700A BR112013008700B8 (pt) 2010-10-11 2011-10-11 Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante

Country Status (15)

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US (4) US20140030292A1 (pt)
EP (4) EP4098325A1 (pt)
JP (3) JP2013544504A (pt)
KR (2) KR102162111B1 (pt)
CN (1) CN103269713B (pt)
AU (2) AU2011316707A1 (pt)
BR (1) BR112013008700B8 (pt)
CA (1) CA2814386C (pt)
CL (1) CL2013000984A1 (pt)
ES (2) ES2716243T3 (pt)
MX (1) MX363307B (pt)
RU (1) RU2597974C2 (pt)
TR (1) TR201903651T4 (pt)
WO (1) WO2012051211A2 (pt)
ZA (1) ZA201302548B (pt)

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