BR0307515A - Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão - Google Patents
Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressãoInfo
- Publication number
- BR0307515A BR0307515A BR0307515-0A BR0307515A BR0307515A BR 0307515 A BR0307515 A BR 0307515A BR 0307515 A BR0307515 A BR 0307515A BR 0307515 A BR0307515 A BR 0307515A
- Authority
- BR
- Brazil
- Prior art keywords
- pressure nozzles
- amorphous drug
- solid amorphous
- dried solid
- drug dispersions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"MéTODO PARA FABRICAR DISPERSõES DE DROGAS AMORFAS SóLIDAS SECAS POR ASPERSãO HOMOGêNEAS USANDO BICOS DE PRESSãO". A presente invenção refere-se a dispersões amorfas sólidas homogêneas de drogas em polímeros potenciadores de concentração que são formadas em desejáveis tamanhos de partícula maiores com finas mínimas usando um atomizador e condições de processo capazes de produzir gotículas tendo um diâmetro de pelo menos 50 microns e um D~ 10~ de pelo menos 10 microns.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35398602P | 2002-02-01 | 2002-02-01 | |
PCT/IB2003/000120 WO2003063821A2 (en) | 2002-02-01 | 2003-01-20 | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0307515A true BR0307515A (pt) | 2004-12-07 |
Family
ID=27663274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0307515-0A BR0307515A (pt) | 2002-02-01 | 2003-01-20 | Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão |
Country Status (20)
Country | Link |
---|---|
US (1) | US7780988B2 (pt) |
EP (1) | EP1469830A2 (pt) |
JP (1) | JP2005523260A (pt) |
KR (1) | KR100758045B1 (pt) |
CN (1) | CN1787808A (pt) |
AR (1) | AR038369A1 (pt) |
AU (1) | AU2003239463B2 (pt) |
BR (1) | BR0307515A (pt) |
CA (1) | CA2474958A1 (pt) |
GT (1) | GT200300024A (pt) |
MX (1) | MXPA04007435A (pt) |
PA (1) | PA8565401A1 (pt) |
PE (1) | PE20030804A1 (pt) |
PL (1) | PL371593A1 (pt) |
RS (1) | RS67304A (pt) |
RU (1) | RU2288703C2 (pt) |
TW (1) | TW200404576A (pt) |
UY (1) | UY27645A1 (pt) |
WO (1) | WO2003063821A2 (pt) |
ZA (1) | ZA200405971B (pt) |
Families Citing this family (59)
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DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
KR100758045B1 (ko) | 2002-02-01 | 2007-09-11 | 화이자 프로덕츠 인크. | 압력 노즐을 이용하여 균질한 분무 건조된 비결정질 고체약물 분산제를 제조하는 방법 |
CN1309370C (zh) | 2002-02-01 | 2007-04-11 | 辉瑞产品公司 | 使用改进的喷雾干燥设备制备均匀喷雾干燥的固体非晶形药物分散体的方法 |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
KR20060123772A (ko) | 2004-06-01 | 2006-12-04 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 약물의 비결정형의 제조 방법 |
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JP2007519757A (ja) | 2004-12-01 | 2007-07-19 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ピメクロリマスの調製方法 |
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ME01305B (me) * | 2006-06-06 | 2012-04-30 | Tibotec Pharm Ltd | Proces za pripremanje raspršivanjem osušenih formulacija tmc125 |
EP2043610B1 (en) | 2006-07-21 | 2015-07-01 | Bend Research, Inc. | Drying of drug-containing particles |
US8613946B2 (en) | 2006-12-21 | 2013-12-24 | Isp Investment Inc. | Carotenoids of enhanced bioavailability |
EP2125938A2 (en) | 2007-01-26 | 2009-12-02 | Isp Investments Inc. | Formulation process method to produce spray dried products |
WO2008137134A2 (en) | 2007-05-01 | 2008-11-13 | Teva Pharmaceuticals Usa, Inc. | Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide |
US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
AU2010210422A1 (en) | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
EP2821400B1 (en) | 2009-03-20 | 2017-09-27 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
ES2873502T3 (es) | 2009-03-27 | 2021-11-03 | Bend Res Inc | Proceso de secado por pulverización |
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US8557995B2 (en) | 2010-06-09 | 2013-10-15 | Abbvie Inc. | Solid dispersions containing kinase inhibitors |
CN103037843A (zh) * | 2010-06-23 | 2013-04-10 | 麦它波莱克斯股份有限公司 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
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US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
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CN103694903B (zh) * | 2013-12-02 | 2015-07-01 | 南通瑞普埃尔生物工程有限公司 | 一种瞬干胶粘剂及其制备方法 |
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AU2015292212B2 (en) | 2014-07-25 | 2019-03-14 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
US10406127B2 (en) | 2014-07-25 | 2019-09-10 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
AU2015330923B2 (en) | 2014-10-07 | 2020-03-12 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
EP3212169B1 (en) | 2014-10-31 | 2021-01-13 | Bend Research, Inc. | Process for forming active domains dispersed in a matrix |
MD3226843T2 (ro) | 2014-12-05 | 2021-10-31 | Aragon Pharmaceuticals Inc | Compoziții anticancer |
MA41107A (fr) * | 2014-12-05 | 2017-10-10 | Aragon Pharmaceuticals Inc | Compositions anti-cancéreuses |
RU2585023C1 (ru) * | 2014-12-18 | 2016-05-27 | Общество с ограниченной ответственностью "Нанолек" | Способ гранулирования |
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US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
DE19613691A1 (de) * | 1996-04-05 | 1997-10-09 | Boehringer Ingelheim Int | Arzneimittel für die Behandlung von Tumorerkrankungen |
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DK0901786T3 (da) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Faste farmaceutiske dispersioner med foröget biotilgængelighed |
US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
DE60042352D1 (de) | 1999-02-10 | 2009-07-23 | Pfizer Prod Inc | Osmotisches System zur Verabreichung von Wirkstoffen, die feste amorphe Dispersionen enthalten |
ES2307482T3 (es) | 1999-02-10 | 2008-12-01 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas. |
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US20010053778A1 (en) | 2000-03-16 | 2001-12-20 | Hoover Dennis J. | Pharmaceutical compositions of glycogen phosphorylase inhibitors |
AR028253A1 (es) * | 2000-03-16 | 2003-04-30 | Pfizer Prod Inc | Inhibidores de la glucogeno fosforilasa |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
CN1309370C (zh) * | 2002-02-01 | 2007-04-11 | 辉瑞产品公司 | 使用改进的喷雾干燥设备制备均匀喷雾干燥的固体非晶形药物分散体的方法 |
KR100758045B1 (ko) | 2002-02-01 | 2007-09-11 | 화이자 프로덕츠 인크. | 압력 노즐을 이용하여 균질한 분무 건조된 비결정질 고체약물 분산제를 제조하는 방법 |
-
2003
- 2003-01-20 KR KR1020047011807A patent/KR100758045B1/ko not_active IP Right Cessation
- 2003-01-20 RS YU67304A patent/RS67304A/sr unknown
- 2003-01-20 AU AU2003239463A patent/AU2003239463B2/en not_active Ceased
- 2003-01-20 EP EP20030700071 patent/EP1469830A2/en not_active Withdrawn
- 2003-01-20 CN CNA038047640A patent/CN1787808A/zh active Pending
- 2003-01-20 BR BR0307515-0A patent/BR0307515A/pt not_active IP Right Cessation
- 2003-01-20 MX MXPA04007435A patent/MXPA04007435A/es active IP Right Grant
- 2003-01-20 PL PL03371593A patent/PL371593A1/xx not_active Application Discontinuation
- 2003-01-20 RU RU2004123639/04A patent/RU2288703C2/ru not_active IP Right Cessation
- 2003-01-20 JP JP2003563515A patent/JP2005523260A/ja active Pending
- 2003-01-20 CA CA002474958A patent/CA2474958A1/en not_active Abandoned
- 2003-01-20 WO PCT/IB2003/000120 patent/WO2003063821A2/en active Application Filing
- 2003-01-24 US US10/351,568 patent/US7780988B2/en active Active
- 2003-01-28 TW TW092101817A patent/TW200404576A/zh unknown
- 2003-01-29 PE PE2003000096A patent/PE20030804A1/es not_active Application Discontinuation
- 2003-01-30 GT GT200300024A patent/GT200300024A/es unknown
- 2003-01-30 AR ARP030100268A patent/AR038369A1/es unknown
- 2003-01-31 UY UY27645A patent/UY27645A1/es not_active Application Discontinuation
- 2003-02-03 PA PA20038565401A patent/PA8565401A1/es unknown
-
2004
- 2004-07-27 ZA ZA200405971A patent/ZA200405971B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20030185893A1 (en) | 2003-10-02 |
RU2004123639A (ru) | 2005-04-20 |
GT200300024A (es) | 2003-09-22 |
US7780988B2 (en) | 2010-08-24 |
KR20040083491A (ko) | 2004-10-02 |
PE20030804A1 (es) | 2003-09-19 |
JP2005523260A (ja) | 2005-08-04 |
PA8565401A1 (es) | 2003-12-10 |
WO2003063821A2 (en) | 2003-08-07 |
WO2003063821A3 (en) | 2003-11-13 |
RS67304A (en) | 2006-10-27 |
ZA200405971B (en) | 2006-05-31 |
UY27645A1 (es) | 2003-09-30 |
RU2288703C2 (ru) | 2006-12-10 |
AU2003239463B2 (en) | 2007-10-18 |
KR100758045B1 (ko) | 2007-09-11 |
PL371593A1 (en) | 2005-06-27 |
MXPA04007435A (es) | 2004-10-11 |
TW200404576A (en) | 2004-04-01 |
AR038369A1 (es) | 2005-01-12 |
CA2474958A1 (en) | 2003-08-07 |
EP1469830A2 (en) | 2004-10-27 |
CN1787808A (zh) | 2006-06-14 |
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