BR0213377A - mìmico de peptìdeo semelhante ao glucagon 1 humano e seu uso no tratamento de diabetes e condições relacionadas - Google Patents
mìmico de peptìdeo semelhante ao glucagon 1 humano e seu uso no tratamento de diabetes e condições relacionadasInfo
- Publication number
- BR0213377A BR0213377A BRPI0213377-6A BR0213377A BR0213377A BR 0213377 A BR0213377 A BR 0213377A BR 0213377 A BR0213377 A BR 0213377A BR 0213377 A BR0213377 A BR 0213377A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- human glucagon
- diabetes
- treatment
- glp
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MìMICO DE PEPTìDEO SEMELHANTE AO GLUCAGON 1 HUMANO E SEU USO NO TRATAMENTO DE DIABETES E CONDIçõES RELACIONADAS". A presente invenção proporciona novos mímicos peptídicos de peptídeo semelhante ao glucagon 1 (GLP-1) humano, que imitam a atividade biológica do peptídeo GLP-1 nativo e, assim, são úteis para o tratamento ou a prevenção de doenças ou distúrbios associados com a atividade do GLP. Além disso, a presente invenção proporciona novos peptídeos quimicamente modificados que não somente estimulam a secreção de insulina em diabéticos do tipo II, como também produzem outras respostas insulinotrópicas benéficas. Estes mímicos peptídicos de GLP-1 sintéticos exibem estabilidade aumentada à clivagem proteolítica, tornando-os candidatos terapêuticos ideais para a administração oral ou parenteral.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34201501P | 2001-10-18 | 2001-10-18 | |
PCT/US2002/033386 WO2003033671A2 (en) | 2001-10-18 | 2002-10-18 | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213377A true BR0213377A (pt) | 2006-05-23 |
Family
ID=23339970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0213377-6A BR0213377A (pt) | 2001-10-18 | 2002-10-18 | mìmico de peptìdeo semelhante ao glucagon 1 humano e seu uso no tratamento de diabetes e condições relacionadas |
Country Status (21)
Country | Link |
---|---|
US (3) | US7238670B2 (pt) |
EP (1) | EP1572892A4 (pt) |
JP (1) | JP2005514337A (pt) |
KR (1) | KR20040054729A (pt) |
CN (1) | CN1630709A (pt) |
AU (1) | AU2002348469B2 (pt) |
BR (1) | BR0213377A (pt) |
CA (1) | CA2463908A1 (pt) |
GE (1) | GEP20063908B (pt) |
HR (1) | HRP20040343A2 (pt) |
HU (1) | HUP0700151A2 (pt) |
IL (1) | IL160917A0 (pt) |
IS (1) | IS7185A (pt) |
MX (1) | MXPA04003553A (pt) |
NO (1) | NO20041203L (pt) |
NZ (1) | NZ531788A (pt) |
PL (1) | PL377687A1 (pt) |
RU (1) | RU2353625C2 (pt) |
WO (1) | WO2003033671A2 (pt) |
YU (1) | YU31004A (pt) |
ZA (1) | ZA200402846B (pt) |
Families Citing this family (88)
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IL160917A0 (en) * | 2001-10-18 | 2004-08-31 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
WO2004022083A1 (en) * | 2002-09-04 | 2004-03-18 | Dsm Ip Assets B.V. | A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
US7530968B2 (en) | 2003-04-23 | 2009-05-12 | Valeritas, Inc. | Hydraulically actuated pump for long duration medicament administration |
CA2545034C (en) | 2003-11-20 | 2013-03-05 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
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- 2002-10-18 IL IL16091702A patent/IL160917A0/xx unknown
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WO2003033671A3 (en) | 2005-12-29 |
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YU31004A (sh) | 2006-08-17 |
NO20041203L (no) | 2004-06-10 |
EP1572892A2 (en) | 2005-09-14 |
EP1572892A4 (en) | 2007-08-22 |
KR20040054729A (ko) | 2004-06-25 |
NZ531788A (en) | 2008-01-31 |
MXPA04003553A (es) | 2004-07-22 |
US7238670B2 (en) | 2007-07-03 |
JP2005514337A (ja) | 2005-05-19 |
PL377687A1 (pl) | 2006-02-06 |
IL160917A0 (en) | 2004-08-31 |
IS7185A (is) | 2004-03-16 |
RU2353625C2 (ru) | 2009-04-27 |
HRP20040343A2 (en) | 2005-08-31 |
WO2003033671A2 (en) | 2003-04-24 |
RU2004114836A (ru) | 2005-04-10 |
CN1630709A (zh) | 2005-06-22 |
AU2002348469B2 (en) | 2008-03-13 |
US20030195157A1 (en) | 2003-10-16 |
GEP20063908B (en) | 2006-08-25 |
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