ES2183376T3 - Uso de lbp para el tratamiento de la septicemia. - Google Patents
Uso de lbp para el tratamiento de la septicemia.Info
- Publication number
- ES2183376T3 ES2183376T3 ES98928139T ES98928139T ES2183376T3 ES 2183376 T3 ES2183376 T3 ES 2183376T3 ES 98928139 T ES98928139 T ES 98928139T ES 98928139 T ES98928139 T ES 98928139T ES 2183376 T3 ES2183376 T3 ES 2183376T3
- Authority
- ES
- Spain
- Prior art keywords
- lbp
- septicemia
- treatment
- therapeutic agent
- mutants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Abstract
La invención se refiere a agentes terapéuticos para tratamiento de la septicemia, su preparación y empleo, con aplicaciones en la industria farmacéutica y en medicina. Estos agentes terapéuticos contienen como elemento esencial la proteína de unión a lipopolisacárido (LBP). La invención también se refiere a proteínas variantes, mutantes e híbridos de la LBP. Se emplea también la murina o LBP de conejo además de la LBP humana.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19729810A DE19729810C2 (de) | 1997-07-11 | 1997-07-11 | Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183376T3 true ES2183376T3 (es) | 2003-03-16 |
Family
ID=7835437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98928139T Expired - Lifetime ES2183376T3 (es) | 1997-07-11 | 1998-04-04 | Uso de lbp para el tratamiento de la septicemia. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6949512B1 (es) |
EP (1) | EP0999849B1 (es) |
JP (1) | JP2001509488A (es) |
AT (1) | ATE223227T1 (es) |
DE (2) | DE19729810C2 (es) |
DK (1) | DK0999849T3 (es) |
ES (1) | ES2183376T3 (es) |
PT (1) | PT999849E (es) |
WO (1) | WO1999002178A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2108372A1 (en) * | 2008-04-09 | 2009-10-14 | Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften | Novel antimicrobial peptides |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0760849A1 (en) * | 1993-04-30 | 1997-03-12 | Incyte Pharmaceuticals, Inc. | Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof |
JPH08503490A (ja) * | 1993-08-18 | 1996-04-16 | モルフォシス・ゲゼルシャフト・フュア・プロタインオプティミールング・ミット・ベシュレンクテル・ハフツング | リポ多糖結合性および中和能のあるペプチド |
WO1995008560A1 (en) * | 1993-09-24 | 1995-03-30 | Centocor, Inc. | Novel peptides useful for inhibiting binding of lipopolysaccharides (lps) by lipopolysaccharide binding protein (lbp) |
US5837810A (en) * | 1994-03-15 | 1998-11-17 | The Scripps Research Institute | Polypeptides of lipopolysaccharide binding protein |
US5990082A (en) * | 1997-10-22 | 1999-11-23 | Xoma Corporation | Uses of lipopolysaccharide binding protein |
-
1997
- 1997-07-11 DE DE19729810A patent/DE19729810C2/de not_active Expired - Fee Related
-
1998
- 1998-04-04 DK DK98928139T patent/DK0999849T3/da active
- 1998-04-04 DE DE59805440T patent/DE59805440D1/de not_active Expired - Lifetime
- 1998-04-04 ES ES98928139T patent/ES2183376T3/es not_active Expired - Lifetime
- 1998-04-04 WO PCT/DE1998/000964 patent/WO1999002178A1/de active IP Right Grant
- 1998-04-04 JP JP2000501768A patent/JP2001509488A/ja active Pending
- 1998-04-04 PT PT98928139T patent/PT999849E/pt unknown
- 1998-04-04 EP EP98928139A patent/EP0999849B1/de not_active Expired - Lifetime
- 1998-04-04 AT AT98928139T patent/ATE223227T1/de not_active IP Right Cessation
-
2000
- 2000-01-13 US US09/484,121 patent/US6949512B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE19729810C2 (de) | 2000-01-13 |
EP0999849A1 (de) | 2000-05-17 |
EP0999849B1 (de) | 2002-09-04 |
JP2001509488A (ja) | 2001-07-24 |
ATE223227T1 (de) | 2002-09-15 |
DK0999849T3 (da) | 2003-01-06 |
PT999849E (pt) | 2003-01-31 |
DE59805440D1 (de) | 2002-10-10 |
WO1999002178A1 (de) | 1999-01-21 |
DE19729810A1 (de) | 1999-01-14 |
US6949512B1 (en) | 2005-09-27 |
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