BR0204588A - Derivados de n-alquil-adamantil-triazinil-benzamida - Google Patents
Derivados de n-alquil-adamantil-triazinil-benzamidaInfo
- Publication number
- BR0204588A BR0204588A BR0204588-5A BR0204588A BR0204588A BR 0204588 A BR0204588 A BR 0204588A BR 0204588 A BR0204588 A BR 0204588A BR 0204588 A BR0204588 A BR 0204588A
- Authority
- BR
- Brazil
- Prior art keywords
- benzamide derivatives
- triazinyl
- alkyl
- alkyl adamantyl
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P17/16—Emollients or protectives, e.g. against radiation
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
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- Surgery (AREA)
Abstract
"DERIVADOS DE N-ALQUIL-ADAMANTILTRIAZINIL-BENZAMIDA". A presente invenção refere-se com novos derivados de N-alquil-adamantil-triazinil-benzamida de fórmula I e com processos para a sua preparação, com intermediários proveitosos na sua preparação, com as composições farmacêuticas que os contêm, e com a sua utilização em terapia. Os compostos ativos da presente invenção são úteis no tratamento da inflamação, osteoartrite, artrite reumatóide, câncer, reperfusão ou isquemia na apoplexia ou ataque cardíaco, doenças auto-imunes e outros distúrbios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33689201P | 2001-11-12 | 2001-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0204588A true BR0204588A (pt) | 2003-09-16 |
Family
ID=23318138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0204588-5A BR0204588A (pt) | 2001-11-12 | 2002-11-07 | Derivados de n-alquil-adamantil-triazinil-benzamida |
Country Status (10)
Country | Link |
---|---|
US (1) | US6927219B2 (pt) |
EP (1) | EP1310493B1 (pt) |
JP (1) | JP4001542B2 (pt) |
AT (1) | ATE302196T1 (pt) |
BR (1) | BR0204588A (pt) |
CA (1) | CA2411544C (pt) |
DE (1) | DE60205564T2 (pt) |
ES (1) | ES2244733T3 (pt) |
MX (1) | MXPA02009783A (pt) |
WO (1) | WO2003042190A1 (pt) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020182646A1 (en) * | 2001-04-30 | 2002-12-05 | Ke Huazhu | Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
ATE365798T1 (de) * | 2003-04-17 | 2007-07-15 | Affectis Pharmaceuticals Ag | Mittel und verfahren zur diagnose und behandlung affektiver störungen |
ES2396565T3 (es) * | 2003-05-12 | 2013-02-22 | Pah Usa 15 Llc | Inhibidores benzamida del receptor P2X7 |
US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
WO2004105797A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
JP2007501270A (ja) * | 2003-05-29 | 2007-01-25 | アストラゼネカ・アクチエボラーグ | P2X7受容体アンタゴニストおよび腫瘍壊死因子αを含む医薬組成物 |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
ITMI20040255A1 (it) * | 2004-02-17 | 2004-05-17 | Univ Degli Studi Milano | Sostanze ad attivita' antiangiogenica |
AU2005229331B2 (en) | 2004-03-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
JPWO2005107804A1 (ja) * | 2004-05-06 | 2008-03-21 | 小野薬品工業株式会社 | 呼吸器疾患治療剤 |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
AU2005258911A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
CN101031305A (zh) * | 2004-09-29 | 2007-09-05 | 兴和株式会社 | 类风湿性关节炎的预防和/或治疗药物 |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
WO2006083214A1 (en) * | 2005-02-02 | 2006-08-10 | Astrazeneca Ab | Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor |
EP1864663A1 (en) * | 2005-03-29 | 2007-12-12 | Kowa Co., Ltd. | Preventive and/or therapeutic agent for rheumatoid arthritis |
US20080207577A1 (en) * | 2005-07-11 | 2008-08-28 | Astrazeneca Ab | Combination I |
WO2007008157A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 2 |
WO2007025900A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
JP4850911B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
CA2620129C (en) * | 2005-09-01 | 2014-12-23 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
WO2007049732A1 (ja) * | 2005-10-28 | 2007-05-03 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療法 |
JPWO2008001499A1 (ja) * | 2006-06-29 | 2009-11-26 | 興和株式会社 | 関節リウマチの予防及び/又は治療薬 |
MX2009010059A (es) | 2007-03-22 | 2009-10-12 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias. |
WO2009019503A2 (en) * | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | P2x7 antagonists for use in the treatment of mood disorders |
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2002
- 2002-09-30 WO PCT/IB2002/004043 patent/WO2003042190A1/en not_active Application Discontinuation
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- 2002-11-07 DE DE60205564T patent/DE60205564T2/de not_active Expired - Lifetime
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JP2003183263A (ja) | 2003-07-03 |
WO2003042190A1 (en) | 2003-05-22 |
CA2411544C (en) | 2008-10-07 |
MXPA02009783A (es) | 2003-05-21 |
EP1310493A1 (en) | 2003-05-14 |
ES2244733T3 (es) | 2005-12-16 |
ATE302196T1 (de) | 2005-09-15 |
DE60205564T2 (de) | 2006-06-01 |
JP4001542B2 (ja) | 2007-10-31 |
US20030144293A1 (en) | 2003-07-31 |
DE60205564D1 (de) | 2005-09-22 |
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