BR0107662A - Antagonistas do fator de liberação de corticotropina - Google Patents
Antagonistas do fator de liberação de corticotropinaInfo
- Publication number
- BR0107662A BR0107662A BR0107662-0A BR0107662A BR0107662A BR 0107662 A BR0107662 A BR 0107662A BR 0107662 A BR0107662 A BR 0107662A BR 0107662 A BR0107662 A BR 0107662A
- Authority
- BR
- Brazil
- Prior art keywords
- corticotropin releasing
- releasing factor
- factor antagonists
- disorders
- antagonists
- Prior art date
Links
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D213/63—One oxygen atom
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- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Abstract
"ANTAGONISTAS DO FATOR DE LIBERAçãO DE CORTICOTROPINA". A invenção refere-se a antagonistas do fator de libertação de corticotropina (CRF) tendo a fórmula (I), (II) ou (III) em que as linhas a tracejado, A, B, Y, Z, G, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 16~ e R~ 17 são como definidas na descrição e processos para a sua preparação. Estes compostos, e seus sais farmaceuticamente aceitáveis são úteis no tratamento de distúrbios que incluem distúrbios do CNS e distúrbios relacionados com o estresse.
Applications Claiming Priority (2)
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US17661100P | 2000-01-18 | 2000-01-18 | |
PCT/IB2001/000004 WO2001053263A1 (en) | 2000-01-18 | 2001-01-05 | Corticotropin releasing factor antagonists |
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BR0107662A true BR0107662A (pt) | 2002-11-19 |
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BR0107662-0A BR0107662A (pt) | 2000-01-18 | 2001-01-05 | Antagonistas do fator de liberação de corticotropina |
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US (1) | US6833378B2 (pt) |
EP (1) | EP1263732A1 (pt) |
JP (1) | JP2003520272A (pt) |
KR (1) | KR20020063934A (pt) |
CN (1) | CN1395566A (pt) |
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AU (1) | AU779995B2 (pt) |
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BR (1) | BR0107662A (pt) |
CA (1) | CA2397633A1 (pt) |
CO (1) | CO5271658A1 (pt) |
CR (1) | CR6698A (pt) |
CZ (1) | CZ20022390A3 (pt) |
EA (2) | EA200200688A1 (pt) |
EE (1) | EE200200400A (pt) |
GT (1) | GT200100007A (pt) |
HN (1) | HN2001000006A (pt) |
HR (1) | HRP20020599A2 (pt) |
HU (1) | HUP0204272A3 (pt) |
IL (1) | IL150632A0 (pt) |
IS (1) | IS6445A (pt) |
MA (1) | MA26864A1 (pt) |
MX (1) | MXPA02007047A (pt) |
NO (1) | NO20023424L (pt) |
OA (1) | OA12157A (pt) |
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PL (1) | PL357589A1 (pt) |
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UY (1) | UY26544A1 (pt) |
WO (1) | WO2001053263A1 (pt) |
YU (1) | YU54402A (pt) |
ZA (1) | ZA200205660B (pt) |
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2001
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- 2001-01-05 EA EA200200688A patent/EA200200688A1/ru unknown
- 2001-01-05 CA CA002397633A patent/CA2397633A1/en not_active Abandoned
- 2001-01-05 AP APAP/P/2002/002583A patent/AP2002002583A0/en unknown
- 2001-01-05 CN CN01803846A patent/CN1395566A/zh active Pending
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- 2001-01-05 KR KR1020027009229A patent/KR20020063934A/ko not_active Application Discontinuation
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