BR0104779A - Taxanos substituìdos com carbonato c10 comoagentes antitumor - Google Patents

Taxanos substituìdos com carbonato c10 comoagentes antitumor

Info

Publication number
BR0104779A
BR0104779A BR0104779-5A BR0104779A BR0104779A BR 0104779 A BR0104779 A BR 0104779A BR 0104779 A BR0104779 A BR 0104779A BR 0104779 A BR0104779 A BR 0104779A
Authority
BR
Brazil
Prior art keywords
taxanes
replaced
carbonate
antitumor agents
agents
Prior art date
Application number
BR0104779-5A
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of BR0104779A publication Critical patent/BR0104779A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)

Abstract

Patente de Invenção: "TAXANOS SUBSTITUìDOS COMCARBONATO C10 COMO AGENTES ANTITUMOR". Taxanostendo um substituinte de carbonato em C(10), um, substituinte dehidróxi em C(7), e uma faixa de C(2), C(9), C(14), e substituintes decadeia lateral.
BR0104779-5A 2000-02-02 2001-02-02 Taxanos substituìdos com carbonato c10 comoagentes antitumor BR0104779A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17968400P 2000-02-02 2000-02-02
PCT/US2001/003588 WO2001057031A1 (en) 2000-02-02 2001-02-02 C10 carbonate substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
BR0104779A true BR0104779A (pt) 2001-12-26

Family

ID=22657547

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104779-5A BR0104779A (pt) 2000-02-02 2001-02-02 Taxanos substituìdos com carbonato c10 comoagentes antitumor

Country Status (25)

Country Link
US (3) US6660866B2 (pt)
EP (1) EP1165550A1 (pt)
JP (1) JP2003522171A (pt)
KR (1) KR20010111582A (pt)
CN (1) CN1186340C (pt)
AU (1) AU782028B2 (pt)
BG (1) BG65298B1 (pt)
BR (1) BR0104779A (pt)
CA (1) CA2368151A1 (pt)
CZ (1) CZ20013405A3 (pt)
GE (1) GEP20043239B (pt)
HK (1) HK1053472A1 (pt)
HU (1) HUP0200759A3 (pt)
IL (1) IL145636A0 (pt)
MX (1) MXPA01009902A (pt)
NO (1) NO20014753L (pt)
NZ (1) NZ514074A (pt)
PL (1) PL350028A1 (pt)
RO (1) RO121269B1 (pt)
RU (1) RU2264400C2 (pt)
SK (1) SK13632001A3 (pt)
TR (1) TR200102855T1 (pt)
UA (1) UA75038C2 (pt)
WO (1) WO2001057031A1 (pt)
ZA (2) ZA200108058B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1186340C (zh) 2000-02-02 2005-01-26 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷
AU776122B2 (en) * 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CZ20013498A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxanové formulace mající zlepąenou rozpustnost
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
WO2009145981A1 (en) * 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
EP0552041B1 (en) 1992-01-15 2000-08-30 E.R. Squibb & Sons, Inc. Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
DE4241664C2 (de) 1992-12-04 1995-04-06 Borus Spezialverfahren Elektronisches Lebensdetektionssystem
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
EP0982301B1 (en) 1993-06-11 2003-09-10 PHARMACIA & UPJOHN COMPANY Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
CA2162759A1 (en) 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5801191A (en) 1995-06-01 1998-09-01 Biophysica Foundation Taxoids
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
FR2742751B1 (fr) 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
JP2000510470A (ja) 1996-05-06 2000-08-15 フロリダ・ステイト・ユニバーシティ １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
JPH1045583A (ja) 1996-05-14 1998-02-17 Tanabe Seiyaku Co Ltd 医薬組成物
CN1097044C (zh) 1996-07-15 2002-12-25 亚库尔特株式会社总社 紫杉烷衍生物以及含有该衍生物的药物
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JP2003026673A (ja) 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
WO2001057013A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
CN1186340C (zh) * 2000-02-02 2005-01-26 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷

Also Published As

Publication number Publication date
UA75038C2 (en) 2006-03-15
AU3330101A (en) 2001-08-14
HK1053472A1 (en) 2003-10-24
CN1429225A (zh) 2003-07-09
US7056946B2 (en) 2006-06-06
PL350028A1 (en) 2002-10-21
CZ20013405A3 (cs) 2002-03-13
ZA200108058B (en) 2003-12-01
RU2264400C2 (ru) 2005-11-20
AU782028B2 (en) 2005-06-30
JP2003522171A (ja) 2003-07-22
NZ514074A (en) 2004-03-26
BG105964A (en) 2002-08-30
HUP0200759A3 (en) 2002-10-28
US6660866B2 (en) 2003-12-09
US20060111401A1 (en) 2006-05-25
CA2368151A1 (en) 2001-08-09
SK13632001A3 (sk) 2002-06-04
MXPA01009902A (es) 2003-07-28
TR200102855T1 (tr) 2002-06-21
GEP20043239B (en) 2004-05-25
US20030114493A1 (en) 2003-06-19
ZA200108054B (en) 2003-12-01
US20040122055A1 (en) 2004-06-24
CN1186340C (zh) 2005-01-26
US7256213B2 (en) 2007-08-14
BG65298B1 (bg) 2007-12-28
WO2001057031A1 (en) 2001-08-09
KR20010111582A (ko) 2001-12-19
EP1165550A1 (en) 2002-01-02
HUP0200759A2 (hu) 2002-07-29
IL145636A0 (en) 2002-06-30
NO20014753L (no) 2001-11-29
NO20014753D0 (no) 2001-10-01
RO121269B1 (ro) 2007-02-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A., 9A., 10A. E 11A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.