BR0104353A - Taxanos heterosubstituìdos com acetato c7 como agentes antitumor - Google Patents

Taxanos heterosubstituìdos com acetato c7 como agentes antitumor

Info

Publication number
BR0104353A
BR0104353A BR0104353-6A BR0104353A BR0104353A BR 0104353 A BR0104353 A BR 0104353A BR 0104353 A BR0104353 A BR 0104353A BR 0104353 A BR0104353 A BR 0104353A
Authority
BR
Brazil
Prior art keywords
taxanes
heterosubstituted
acetate
antitumor agents
agents
Prior art date
Application number
BR0104353-6A
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of BR0104353A publication Critical patent/BR0104353A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)

Abstract

Patente de Invenção: "TAXANOS HETEROSUBSTITUìDOS COM ACETATO C7 COMO AGENTES ANTITUMOR". Taxanos tendo um substituintes de acetato heterosubstituído em C(7), um substituinte de hidroxido em C(10), e uma faixa de C(2), C(9), C(14), e substituintes de cadeia lateral.
BR0104353-6A 2000-02-02 2001-02-02 Taxanos heterosubstituìdos com acetato c7 como agentes antitumor BR0104353A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967200P 2000-02-02 2000-02-02
PCT/US2001/003600 WO2001057029A1 (en) 2000-02-02 2001-02-02 C7 heterosubstituted acetate taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
BR0104353A true BR0104353A (pt) 2002-04-16

Family

ID=22657505

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104353-6A BR0104353A (pt) 2000-02-02 2001-02-02 Taxanos heterosubstituìdos com acetato c7 como agentes antitumor

Country Status (20)

Country Link
US (3) US6673833B2 (pt)
EP (1) EP1200424B1 (pt)
JP (1) JP2003522169A (pt)
KR (1) KR20010112393A (pt)
CN (1) CN1362957A (pt)
AT (1) ATE413397T1 (pt)
AU (1) AU776765B2 (pt)
BR (1) BR0104353A (pt)
CA (1) CA2368534A1 (pt)
CZ (1) CZ20013519A3 (pt)
DE (1) DE60136430D1 (pt)
HK (1) HK1047935A1 (pt)
HU (1) HUP0200651A3 (pt)
IL (1) IL145642A0 (pt)
MX (1) MXPA01009922A (pt)
NO (1) NO20014758L (pt)
NZ (1) NZ514411A (pt)
PL (1) PL350328A1 (pt)
WO (1) WO2001057029A1 (pt)
ZA (1) ZA200108063B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057029A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
US20040210289A1 (en) * 2002-03-04 2004-10-21 Xingwu Wang Novel nanomagnetic particles
KR20050032110A (ko) * 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
JP2007527432A (ja) * 2004-03-05 2007-09-27 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ７ラクチルオキシ置換タキサン
US20050249667A1 (en) * 2004-03-24 2005-11-10 Tuszynski Jack A Process for treating a biological organism
CN1712399B (zh) * 2004-06-24 2010-08-11 中国医学科学院药物研究所 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
EP3239139B1 (en) 2010-05-27 2020-10-28 Ningbo Combireg Pharmaceutical Technology Co. Ltd Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

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US4879929A (en) * 1988-06-06 1989-11-14 Roth Alfred C Tapper/threader assembly
US4950790A (en) * 1988-11-14 1990-08-21 Air Products And Chemicals, Inc. Volatile fluorinated β-ketoimines and associated metal complexes
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5243253A (en) * 1991-07-30 1993-09-07 Thomson Consumer Electronics, Inc. Color picture tube having shadow mask with improved tie bar grading
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
DE69333675T2 (de) 1992-01-15 2006-02-02 E.R. Squibb & Sons, Inc. Enzymatische Verfahren zur Trennung von Enantiomerengemischen von Verbindungen, die als Zwischenprodukte zur Herstellung von Taxanen nützlich sind
DE4302686C2 (de) * 1992-02-05 1994-12-15 Bierther Hans Dietmar Hochleistungsventil
FR2687150B1 (fr) 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
EP0689436B1 (en) * 1993-03-22 2003-11-26 Florida State University Taxanes not having an oxo group at c-9 and pharmaceutical compositions containing same
US5350253A (en) * 1993-03-24 1994-09-27 John Cunningham Method for supporting distribution means
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
JP3786462B2 (ja) 1996-03-07 2006-06-14 塩水港精糖株式会社 タキソイドの配糖化誘導体およびその製造方法
WO1997042181A1 (en) 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5780683A (en) * 1996-09-11 1998-07-14 Abb Lummus Global Inc. Cyclohexane oxidation
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
HU224589B1 (hu) * 1997-06-03 2005-11-28 Ensuiko Sugar Refining Co., Ltd. Taxoidszármazékok és eljárás előállításukra
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
BR0104358A (pt) 2000-02-02 2002-01-02 Univ Florida State Res Found Formulações de taxana tendo solubilidade aperfeiçoada
WO2001057029A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents

Also Published As

Publication number Publication date
AU3480401A (en) 2001-08-14
US20020065305A1 (en) 2002-05-30
JP2003522169A (ja) 2003-07-22
MXPA01009922A (es) 2003-07-14
CZ20013519A3 (cs) 2002-04-17
IL145642A0 (en) 2002-06-30
PL350328A1 (en) 2002-12-02
ZA200108063B (en) 2003-12-01
US7183312B2 (en) 2007-02-27
AU776765B2 (en) 2004-09-23
WO2001057029A1 (en) 2001-08-09
NZ514411A (en) 2005-02-25
HUP0200651A3 (en) 2002-10-28
CN1362957A (zh) 2002-08-07
EP1200424B1 (en) 2008-11-05
US6861446B2 (en) 2005-03-01
ATE413397T1 (de) 2008-11-15
NO20014758D0 (no) 2001-10-01
KR20010112393A (ko) 2001-12-20
HUP0200651A2 (hu) 2002-07-29
HK1047935A1 (zh) 2003-03-14
CA2368534A1 (en) 2001-08-09
DE60136430D1 (de) 2008-12-18
US6673833B2 (en) 2004-01-06
NO20014758L (no) 2001-11-29
US20040087547A1 (en) 2004-05-06
US20050143446A1 (en) 2005-06-30
EP1200424A1 (en) 2002-05-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A., 9A., 10A. E 11A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.