BR0014515A - Derivados de propil tienoisoxazolil- e tienilpirrazolil-fenóxi substituìdos úteis como antagonistas de d4 - Google Patents

Derivados de propil tienoisoxazolil- e tienilpirrazolil-fenóxi substituìdos úteis como antagonistas de d4

Info

Publication number
BR0014515A
BR0014515A BR0014515-7A BR0014515A BR0014515A BR 0014515 A BR0014515 A BR 0014515A BR 0014515 A BR0014515 A BR 0014515A BR 0014515 A BR0014515 A BR 0014515A
Authority
BR
Brazil
Prior art keywords
derivatives useful
disorder
thienoisoxazolyl
thienylpyrazolyl
antagonists
Prior art date
Application number
BR0014515-7A
Other languages
English (en)
Inventor
David M Fink
Brian S Freed
Nicholas J Hrib
Raymond W Kosley Jr
George E Lee
Gregory H Merriman
Barbara S Rauckman
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BR0014515A publication Critical patent/BR0014515A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE PROPIL TIENOISOXAZOLIL- E TIENILPIRRAZOLIL-FENóXI SUBSTUTUìDOS úTEIS COMO ANTAGO-NISTAS DE D~ 4~". Os compostos são de classe dos derivados de propil substituído com tienoisoxazolil- e tienilpirrazolil- fenóxi, úteis como antagonistas D~ 4~. OS ditos compostos são úteis no tratamento de condições médicas mediadas pela inibição do receptor D~ 4~. Tais condições compreendem, por exemplo, desordem de hiperatividade da deficit de atenção, desordens de compulsão obsessiva, psicose, abuso de substâncias, dependência de substâncias, mal de Parkinson, Parkinsonismo, disquenésia tardia, síndrome de Grilles de La Tourette, desordem da condução e desordem de provocação oposicional. Um aspecto adicional da presente invenção é o de prover uma composição farmacêutica, intermediários e um processo de preparação das ditas classes de compostos.
BR0014515-7A 1999-09-14 2000-09-13 Derivados de propil tienoisoxazolil- e tienilpirrazolil-fenóxi substituìdos úteis como antagonistas de d4 BR0014515A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39608199A 1999-09-14 1999-09-14
PCT/US2000/024962 WO2001019833A1 (en) 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists

Publications (1)

Publication Number Publication Date
BR0014515A true BR0014515A (pt) 2002-06-25

Family

ID=23565772

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014515-7A BR0014515A (pt) 1999-09-14 2000-09-13 Derivados de propil tienoisoxazolil- e tienilpirrazolil-fenóxi substituìdos úteis como antagonistas de d4

Country Status (26)

Country Link
EP (1) EP1216250B1 (pt)
JP (1) JP4847662B2 (pt)
KR (1) KR20020027647A (pt)
AR (1) AR032134A1 (pt)
AT (1) ATE254621T1 (pt)
AU (1) AU7577400A (pt)
BR (1) BR0014515A (pt)
CA (1) CA2383340C (pt)
CY (1) CY1101692T1 (pt)
CZ (1) CZ2002897A3 (pt)
DE (1) DE60006699T2 (pt)
DK (1) DK1216250T3 (pt)
EA (1) EA200200355A1 (pt)
EE (1) EE200200135A (pt)
ES (1) ES2209995T3 (pt)
HR (1) HRP20020220A2 (pt)
HU (1) HUP0203526A3 (pt)
IL (1) IL148623A0 (pt)
MX (1) MXPA02002695A (pt)
NO (1) NO20021251L (pt)
PL (1) PL354515A1 (pt)
PT (1) PT1216250E (pt)
SK (1) SK3512002A3 (pt)
TW (1) TW530060B (pt)
WO (1) WO2001019833A1 (pt)
ZA (1) ZA200201762B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
CA2438318A1 (en) * 2001-02-16 2002-08-29 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
EP1380576B1 (en) 2001-04-16 2009-11-25 Eisai R&D Management Co., Ltd. 1h-indazole compounds inhibiting jnk
KR20040020457A (ko) * 2002-08-30 2004-03-09 주식회사 대웅 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
WO2004069818A1 (en) * 2003-01-17 2004-08-19 Cv Therapeutics Inc. Substituted heterocyclic compounds useful in the treatment of cardiovascular diseases
JP2007297321A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd アリール２−メチルグリシジルエーテル類の製造法
JP2007297330A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd ２−メチルグリシジル誘導体の製造法
US9365555B2 (en) 2012-12-21 2016-06-14 Epizyme, Inc. PRMT5 inhibitors and uses thereof
DK2935222T3 (en) 2012-12-21 2019-01-07 Epizyme Inc PRMT5 INHIBITORS AND APPLICATIONS THEREOF
JP2016505597A (ja) 2012-12-21 2016-02-25 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
WO2015200680A2 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP2017530940A (ja) 2014-08-04 2017-10-19 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
PT1054885E (pt) * 1998-02-09 2007-10-03 Duphar Int Res Derivativos de benzisoxazole tendo uma actividade d4-antagonista

Also Published As

Publication number Publication date
HUP0203526A3 (en) 2004-12-28
HUP0203526A2 (hu) 2003-01-28
KR20020027647A (ko) 2002-04-13
HRP20020220A2 (en) 2004-02-29
JP2003509432A (ja) 2003-03-11
ATE254621T1 (de) 2003-12-15
PL354515A1 (en) 2004-01-26
TW530060B (en) 2003-05-01
CA2383340C (en) 2010-06-15
DK1216250T3 (da) 2004-02-23
AU7577400A (en) 2001-04-17
CA2383340A1 (en) 2001-03-22
CY1101692T1 (el) 2010-07-28
CZ2002897A3 (cs) 2002-07-17
ZA200201762B (en) 2003-08-27
DE60006699D1 (en) 2003-12-24
EE200200135A (et) 2003-04-15
MXPA02002695A (es) 2002-07-30
SK3512002A3 (en) 2003-03-04
NO20021251L (no) 2002-05-10
IL148623A0 (en) 2002-09-12
PT1216250E (pt) 2004-04-30
WO2001019833A1 (en) 2001-03-22
ES2209995T3 (es) 2004-07-01
JP4847662B2 (ja) 2011-12-28
DE60006699T2 (de) 2004-09-30
AR032134A1 (es) 2003-10-29
EP1216250A1 (en) 2002-06-26
EP1216250B1 (en) 2003-11-19
EA200200355A1 (ru) 2002-10-31
NO20021251D0 (no) 2002-03-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.