BG63662B1 - Нови субституирани циклични аминокиселини като фармацевтични средства - Google Patents
Нови субституирани циклични аминокиселини като фармацевтични средства Download PDFInfo
- Publication number
- BG63662B1 BG63662B1 BG102733A BG10273398A BG63662B1 BG 63662 B1 BG63662 B1 BG 63662B1 BG 102733 A BG102733 A BG 102733A BG 10273398 A BG10273398 A BG 10273398A BG 63662 B1 BG63662 B1 BG 63662B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- acetic acid
- cyclohexyl
- compound
- aminomethyl
- Prior art date
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- -1 cyclic amino acids Chemical class 0.000 title claims abstract description 22
- 150000001875 compounds Chemical class 0.000 claims abstract description 52
- 238000000034 method Methods 0.000 claims abstract description 20
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- 206010015037 epilepsy Diseases 0.000 claims abstract description 7
- 230000036407 pain Effects 0.000 claims abstract description 7
- 230000002981 neuropathic effect Effects 0.000 claims abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 9
- ZMQXNOCRKMCKKX-UHFFFAOYSA-N 2-[1-(aminomethyl)-4-methylcyclohexyl]acetic acid Chemical compound CC1CCC(CN)(CC(O)=O)CC1 ZMQXNOCRKMCKKX-UHFFFAOYSA-N 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- UOPIILYKLVDKTK-UHFFFAOYSA-N 2-[1-(aminomethyl)-3-methylcyclohexyl]acetic acid Chemical compound CC1CCCC(CN)(CC(O)=O)C1 UOPIILYKLVDKTK-UHFFFAOYSA-N 0.000 claims description 6
- 206010010904 Convulsion Diseases 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
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- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
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- 125000001424 substituent group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 208000006083 Hypokinesia Diseases 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 230000003483 hypokinetic effect Effects 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
- WGIBTIBNUDBDKS-UHFFFAOYSA-N 2-[1-(aminomethyl)-3,3,5,5-tetramethylcyclohexyl]acetic acid Chemical compound CC1(C)CC(C)(C)CC(CN)(CC(O)=O)C1 WGIBTIBNUDBDKS-UHFFFAOYSA-N 0.000 claims description 2
- SDDWVDGIHSCXOM-UHFFFAOYSA-N 2-[1-(aminomethyl)-4-tert-butylcyclohexyl]acetic acid Chemical compound CC(C)(C)C1CCC(CN)(CC(O)=O)CC1 SDDWVDGIHSCXOM-UHFFFAOYSA-N 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- FDOZSFMPSARACP-UHFFFAOYSA-N methyl 2-[1-(aminomethyl)-3-methylcyclohexyl]acetate;hydrochloride Chemical compound Cl.COC(=O)CC1(CN)CCCC(C)C1 FDOZSFMPSARACP-UHFFFAOYSA-N 0.000 claims description 2
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- WJGAPUXHSQQWQF-UHFFFAOYSA-N acetic acid;hydrochloride Chemical compound Cl.CC(O)=O WJGAPUXHSQQWQF-UHFFFAOYSA-N 0.000 claims 1
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 52
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1343296P | 1996-03-14 | 1996-03-14 | |
| PCT/US1997/002295 WO1997033858A1 (en) | 1996-03-14 | 1997-02-18 | Novel substituted cyclic amino acids as pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102733A BG102733A (en) | 1999-04-30 |
| BG63662B1 true BG63662B1 (bg) | 2002-08-30 |
Family
ID=21759938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102733A BG63662B1 (bg) | 1996-03-14 | 1998-08-28 | Нови субституирани циклични аминокиселини като фармацевтични средства |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6103932A (pl) |
| EP (1) | EP0888286B1 (pl) |
| JP (1) | JP2000506861A (pl) |
| KR (1) | KR100512506B1 (pl) |
| AT (1) | ATE207878T1 (pl) |
| AU (1) | AU734173B2 (pl) |
| BG (1) | BG63662B1 (pl) |
| BR (1) | BR9708200A (pl) |
| CA (1) | CA2244912C (pl) |
| CZ (1) | CZ293759B6 (pl) |
| DE (1) | DE69707842T2 (pl) |
| DK (2) | DK0888285T3 (pl) |
| EA (1) | EA002765B1 (pl) |
| EE (1) | EE9800309A (pl) |
| ES (1) | ES2167717T3 (pl) |
| GE (1) | GEP20012413B (pl) |
| HU (1) | HU224720B1 (pl) |
| IL (1) | IL125544A (pl) |
| IS (1) | IS1990B (pl) |
| MX (1) | MX9806069A (pl) |
| NO (1) | NO984205L (pl) |
| NZ (1) | NZ331143A (pl) |
| PL (1) | PL185991B1 (pl) |
| PT (1) | PT888286E (pl) |
| SK (1) | SK283295B6 (pl) |
| TR (1) | TR199801807T2 (pl) |
| UA (1) | UA49011C2 (pl) |
| WO (1) | WO1997033858A1 (pl) |
| ZA (1) | ZA972200B (pl) |
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-
1997
- 1997-02-18 PT PT97908655T patent/PT888286E/pt unknown
- 1997-02-18 CA CA002244912A patent/CA2244912C/en not_active Expired - Fee Related
- 1997-02-18 GE GEAP19974526A patent/GEP20012413B/en unknown
- 1997-02-18 EA EA199800798A patent/EA002765B1/ru unknown
- 1997-02-18 TR TR1998/01807T patent/TR199801807T2/xx unknown
- 1997-02-18 HU HU9902136A patent/HU224720B1/hu not_active IP Right Cessation
- 1997-02-18 SK SK1238-98A patent/SK283295B6/sk unknown
- 1997-02-18 KR KR10-1998-0707229A patent/KR100512506B1/ko not_active IP Right Cessation
- 1997-02-18 IL IL12554497A patent/IL125544A/en not_active IP Right Cessation
- 1997-02-18 JP JP9532601A patent/JP2000506861A/ja not_active Ceased
- 1997-02-18 DK DK97906630T patent/DK0888285T3/da active
- 1997-02-18 AT AT97908655T patent/ATE207878T1/de not_active IP Right Cessation
- 1997-02-18 UA UA98105386A patent/UA49011C2/uk unknown
- 1997-02-18 US US09/068,874 patent/US6103932A/en not_active Expired - Fee Related
- 1997-02-18 BR BR9708200A patent/BR9708200A/pt not_active Application Discontinuation
- 1997-02-18 CZ CZ19982863A patent/CZ293759B6/cs not_active IP Right Cessation
- 1997-02-18 DK DK97908655T patent/DK0888286T3/da active
- 1997-02-18 PL PL97328816A patent/PL185991B1/pl not_active IP Right Cessation
- 1997-02-18 NZ NZ331143A patent/NZ331143A/en unknown
- 1997-02-18 ES ES97908655T patent/ES2167717T3/es not_active Expired - Lifetime
- 1997-02-18 EP EP97908655A patent/EP0888286B1/en not_active Expired - Lifetime
- 1997-02-18 WO PCT/US1997/002295 patent/WO1997033858A1/en active IP Right Grant
- 1997-02-18 AU AU20511/97A patent/AU734173B2/en not_active Ceased
- 1997-02-18 DE DE69707842T patent/DE69707842T2/de not_active Expired - Fee Related
- 1997-02-18 EE EE9800309A patent/EE9800309A/xx unknown
- 1997-03-13 ZA ZA9702200A patent/ZA972200B/xx unknown
-
1998
- 1998-07-28 MX MX9806069A patent/MX9806069A/es active IP Right Grant
- 1998-08-10 IS IS4819A patent/IS1990B/is unknown
- 1998-08-28 BG BG102733A patent/BG63662B1/bg unknown
- 1998-09-11 NO NO984205A patent/NO984205L/no not_active Application Discontinuation
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