MX9806069A - Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos. - Google Patents
Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos.Info
- Publication number
- MX9806069A MX9806069A MX9806069A MX9806069A MX9806069A MX 9806069 A MX9806069 A MX 9806069A MX 9806069 A MX9806069 A MX 9806069A MX 9806069 A MX9806069 A MX 9806069A MX 9806069 A MX9806069 A MX 9806069A
- Authority
- MX
- Mexico
- Prior art keywords
- amino acids
- cyclic amino
- substituted cyclic
- novel substituted
- pharmaceutical agents
- Prior art date
Links
- -1 cyclic amino acids Chemical class 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Novedosos amino ácidos cíclicos substituidos de la formula (I) se presentan y son utiles como agentes en el tratamiento de epilepsia, ataques de mareos, hipoquinesia, desordenes craneales, desordenes neurodegenerativos, depresion, ansiedad, pánico, dolor y desordenes neuropatologicos. Procesos para la preparacion e intermediarios utiles en la preparacion también se presentan.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1343296P | 1996-03-14 | 1996-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9806069A true MX9806069A (es) | 1998-11-30 |
Family
ID=21759938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9806069A MX9806069A (es) | 1996-03-14 | 1998-07-28 | Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos. |
Country Status (29)
Country | Link |
---|---|
US (1) | US6103932A (es) |
EP (1) | EP0888286B1 (es) |
JP (1) | JP2000506861A (es) |
KR (1) | KR100512506B1 (es) |
AT (1) | ATE207878T1 (es) |
AU (1) | AU734173B2 (es) |
BG (1) | BG63662B1 (es) |
BR (1) | BR9708200A (es) |
CA (1) | CA2244912C (es) |
CZ (1) | CZ293759B6 (es) |
DE (1) | DE69707842T2 (es) |
DK (2) | DK0888285T3 (es) |
EA (1) | EA002765B1 (es) |
EE (1) | EE9800309A (es) |
ES (1) | ES2167717T3 (es) |
GE (1) | GEP20012413B (es) |
HU (1) | HU224720B1 (es) |
IL (1) | IL125544A (es) |
IS (1) | IS1990B (es) |
MX (1) | MX9806069A (es) |
NO (1) | NO984205L (es) |
NZ (1) | NZ331143A (es) |
PL (1) | PL185991B1 (es) |
PT (1) | PT888286E (es) |
SK (1) | SK283295B6 (es) |
TR (1) | TR199801807T2 (es) |
UA (1) | UA49011C2 (es) |
WO (1) | WO1997033858A1 (es) |
ZA (1) | ZA972200B (es) |
Families Citing this family (62)
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US6001876A (en) | 1996-07-24 | 1999-12-14 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
BR9813284B1 (pt) * | 1997-10-27 | 2012-08-21 | aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica. | |
DE19751062A1 (de) | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
BR9814286A (pt) * | 1997-12-16 | 2000-10-03 | Warner Lambert Co | Derivados de 1-substituìdo-1-aminometil-cicloalcano (=análogos de gabapentina), sua preparação e seu uso no tratamento de distúrbios neurológicos |
KR20010071777A (ko) | 1998-07-09 | 2001-07-31 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Gaba 유사체 및 카페인을 포함하는 조성물 |
EP1031350A1 (en) * | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
CA2361647A1 (en) * | 1999-12-08 | 2001-06-14 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy |
JP2003528148A (ja) * | 2000-03-28 | 2003-09-24 | デロレンゾ、ロバート・ジェイ | 損傷に際して神経細胞中に形成される新規カルシウム損傷電流の阻害は神経細胞死を抑制する |
GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
DE10048715A1 (de) * | 2000-09-30 | 2004-05-19 | Grünenthal GmbH | Verwendung von Aminosäure zur Behandlung von Schmerz |
WO2002032376A2 (en) | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
EP1343805A4 (en) * | 2000-10-06 | 2005-07-20 | Xenoport Inc | COMPOUNDS DERIVED FROM GALLENIC ACIDS FOR THE PROVISION OF CONTINUING SYSTEMIC CONCENTRATIONS OF MEDICINAL PRODUCTS AFTER ORAL ADMINISTRATION |
US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
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US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
ES2380287T3 (es) * | 2001-06-11 | 2012-05-10 | Xenoport, Inc. | Profármacos de análogos de GABA, composiciones y sus usos |
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US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
EP1412324A4 (en) * | 2001-06-11 | 2004-09-29 | Xenoport Inc | AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS |
CN1642547A (zh) * | 2002-01-16 | 2005-07-20 | 恩多制药公司 | 治疗中枢神经***障碍的药物组合物和方法 |
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WO2003080588A1 (en) | 2002-03-20 | 2003-10-02 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
US20050153928A1 (en) * | 2002-05-07 | 2005-07-14 | Holick Michael F. | Conjugates comprising a central nervous system-active drug linked to glucuronic acid or glucosamine through an amide bond and uses thereof |
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CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
BR0316572A (pt) | 2002-12-13 | 2005-10-04 | Warner Lambert Co | Ligando alfa-2-delta para o tratamento de sintomas do trato variáveis inferior, utilização e produto deste |
GB0301143D0 (en) * | 2003-01-17 | 2003-02-19 | Amedis Pharm Ltd | Compounds and their use |
JP2006522146A (ja) * | 2003-03-31 | 2006-09-28 | ゼノポート,インコーポレイティド | Gaba類似体のプロドラッグを使用するのぼせの治療または予防 |
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ATE449633T1 (de) | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
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PT1691811E (pt) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
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CA2570255A1 (en) * | 2004-03-17 | 2005-09-22 | Hikal Limited | 4-t-butylgabapentin and its synthesis |
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SI2125021T1 (sl) | 2006-12-22 | 2011-09-30 | Recordati Ireland Ltd | Kombinirano zdravljenje bolezni spodnjega urinarnega trakta z alfa2delta ligandi in NSAR |
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CA2706575C (en) | 2008-01-25 | 2015-07-14 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
US7872046B2 (en) | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
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AU2009302241B2 (en) * | 2008-10-08 | 2015-10-29 | Xgene Pharmaceutical Inc. | GABA conjugates and methods of use thereof |
US8168756B2 (en) | 2008-10-24 | 2012-05-01 | Ark Diagnostics, Inc. | Levetiracetam immunoassays |
US9192681B2 (en) | 2009-02-24 | 2015-11-24 | Nektar Therapeutics | Oligomer-amino acid conjugates |
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US20110124705A1 (en) * | 2009-11-24 | 2011-05-26 | Xenoport, Inc. | Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
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-
1997
- 1997-02-18 EP EP97908655A patent/EP0888286B1/en not_active Expired - Lifetime
- 1997-02-18 TR TR1998/01807T patent/TR199801807T2/xx unknown
- 1997-02-18 PL PL97328816A patent/PL185991B1/pl not_active IP Right Cessation
- 1997-02-18 AU AU20511/97A patent/AU734173B2/en not_active Ceased
- 1997-02-18 BR BR9708200A patent/BR9708200A/pt not_active Application Discontinuation
- 1997-02-18 UA UA98105386A patent/UA49011C2/uk unknown
- 1997-02-18 CZ CZ19982863A patent/CZ293759B6/cs not_active IP Right Cessation
- 1997-02-18 SK SK1238-98A patent/SK283295B6/sk unknown
- 1997-02-18 JP JP9532601A patent/JP2000506861A/ja not_active Ceased
- 1997-02-18 HU HU9902136A patent/HU224720B1/hu not_active IP Right Cessation
- 1997-02-18 KR KR10-1998-0707229A patent/KR100512506B1/ko not_active IP Right Cessation
- 1997-02-18 US US09/068,874 patent/US6103932A/en not_active Expired - Fee Related
- 1997-02-18 DK DK97906630T patent/DK0888285T3/da active
- 1997-02-18 GE GEAP19974526A patent/GEP20012413B/en unknown
- 1997-02-18 ES ES97908655T patent/ES2167717T3/es not_active Expired - Lifetime
- 1997-02-18 NZ NZ331143A patent/NZ331143A/en unknown
- 1997-02-18 CA CA002244912A patent/CA2244912C/en not_active Expired - Fee Related
- 1997-02-18 EE EE9800309A patent/EE9800309A/xx unknown
- 1997-02-18 EA EA199800798A patent/EA002765B1/ru unknown
- 1997-02-18 WO PCT/US1997/002295 patent/WO1997033858A1/en active IP Right Grant
- 1997-02-18 DE DE69707842T patent/DE69707842T2/de not_active Expired - Fee Related
- 1997-02-18 DK DK97908655T patent/DK0888286T3/da active
- 1997-02-18 PT PT97908655T patent/PT888286E/pt unknown
- 1997-02-18 IL IL12554497A patent/IL125544A/en not_active IP Right Cessation
- 1997-02-18 AT AT97908655T patent/ATE207878T1/de not_active IP Right Cessation
- 1997-03-13 ZA ZA9702200A patent/ZA972200B/xx unknown
-
1998
- 1998-07-28 MX MX9806069A patent/MX9806069A/es active IP Right Grant
- 1998-08-10 IS IS4819A patent/IS1990B/is unknown
- 1998-08-28 BG BG102733A patent/BG63662B1/bg unknown
- 1998-09-11 NO NO984205A patent/NO984205L/no not_active Application Discontinuation
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