BG61059B2 - Аналози на дономицина - Google Patents

Аналози на дономицина Download PDF

Info

Publication number: BG61059B2
Authority: BG; Bulgaria
Prior art keywords: donosaminylc; demethoxidonomycinone; sepimers; epimers; compounds
Prior art date: 1974-06-12

Application number

BG098211A

Other languages

Bulgarian (bg)

English (en)

Inventor

Bianca Patelli

Luigi Bernardi

Federico Arcamone

Aurelio Marco

Original Assignee

Farmitalia Carlo Erba S.R.L.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-12

Filing date

1993-11-11

Publication date

1996-09-30

1993-11-11 Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.

1996-09-30 Publication of BG61059B2 publication Critical patent/BG61059B2/bg

Links

STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 claims abstract description 3
150000001875 compounds Chemical class 0.000 claims description 22
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
229910052801 chlorine Inorganic materials 0.000 claims description 4
239000000460 chlorine Substances 0.000 claims description 3
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 2
125000001309 chloro group Chemical group Cl* 0.000 claims description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
239000003054 catalyst Substances 0.000 claims 1
YMMTXWRRJUTBEI-LYTHVRBOSA-N epimer a Chemical compound O=C1NC2=NC=CC=C2[C@@]1(CC1=C2)CC1=CC=C2NC(=O)CN1C(C=CC=C2NC(=O)C3)=C2C3C1 YMMTXWRRJUTBEI-LYTHVRBOSA-N 0.000 claims 1
239000003960 organic solvent Substances 0.000 claims 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
230000000144 pharmacologic effect Effects 0.000 abstract description 3
238000002360 preparation method Methods 0.000 abstract description 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 25
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
229940009456 adriamycin Drugs 0.000 description 13
206010028980 Neoplasm Diseases 0.000 description 11
210000004027 cell Anatomy 0.000 description 9
239000000203 mixture Substances 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000000741 silica gel Substances 0.000 description 6
229910002027 silica gel Inorganic materials 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
241000699670 Mus sp. Species 0.000 description 4
230000004083 survival effect Effects 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
238000002513 implantation Methods 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
239000002904 solvent Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
229940045799 anthracyclines and related substance Drugs 0.000 description 2
230000000259 anti-tumor effect Effects 0.000 description 2
238000003556 assay Methods 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000011712 cell development Effects 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
208000032839 leukemia Diseases 0.000 description 2
239000002808 molecular sieve Substances 0.000 description 2
230000001613 neoplastic effect Effects 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
238000003756 stirring Methods 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
206010003445 Ascites Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
241000713862 Moloney murine sarcoma virus Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
208000006268 Sarcoma 180 Diseases 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
244000309466 calf Species 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003480 eluent Substances 0.000 description 1
210000002257 embryonic structure Anatomy 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
NGYIMTKLQULBOO-UHFFFAOYSA-L mercury dibromide Chemical compound Br[Hg]Br NGYIMTKLQULBOO-UHFFFAOYSA-L 0.000 description 1
229910000474 mercury oxide Inorganic materials 0.000 description 1
UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
230000005748 tumor development Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

BG098211A 1974-06-12 1993-11-11 Аналози на дономицина BG61059B2 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2608374A GB1467383A (en)	1974-06-12	1974-06-12	Daunomycin analogues

Publications (1)

Publication Number	Publication Date
BG61059B2 true BG61059B2 (bg)	1996-09-30

Family

ID=10238087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG098211A BG61059B2 (bg)	1974-06-12	1993-11-11	Аналози на дономицина

Country Status (17)

Country	Link
US (1)	US4046878A (ru)
JP (1)	JPS5840557B2 (ru)
AT (1)	AT337363B (ru)
BE (1)	BE830090A (ru)
BG (1)	BG61059B2 (ru)
CH (1)	CH611317A5 (ru)
DE (2)	DE2525633A1 (ru)
DK (1)	DK147304C (ru)
ES (1)	ES438431A1 (ru)
FR (1)	FR2274629A1 (ru)
GB (1)	GB1467383A (ru)
HK (1)	HK982A (ru)
MY (1)	MY103666A (ru)
NL (1)	NL173272C (ru)
SE (1)	SE423633B (ru)
SU (1)	SU645588A3 (ru)
ZA (1)	ZA753722B (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1506200A (en) *	1975-04-30	1978-04-05	Farmaceutici Italia	Glycosides
GB1509875A (en) *	1976-06-14	1978-05-04	Farmaceutici Italia	Optically active anthracyclinones and anthracycline glycosides
US4161480A (en) *	1978-06-05	1979-07-17	G. D. Searle & Co.	Intermediates for the synthesis of 4-demethoxydaunorubicin
US4201773A (en) *	1978-07-26	1980-05-06	The United States Of America As Represented By The Department Of Health, Education And Welfare	7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IL55431A (en) *	1978-08-24	1982-07-30	Yeda Res & Dev	Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) *	1979-03-17	1980-09-19	Erba Farmitalia	Antitumorglycosiden.
JPS5673039A (en) *	1979-08-20	1981-06-17	Hoffmann La Roche	Naphthacene derivative
CA1154013A (en) *	1979-09-01	1983-09-20	Alberto Bargiotti	Antitumor glycosides, their preparation, use and compositions thereof
DE3100968A1 (de) *	1980-01-16	1982-01-14	Farmitalia Carlo Erba S.p.A., 20159 Milano	Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4348388A (en) *	1980-04-02	1982-09-07	G.D. Searle & Co.	11-Amino-11-deoxydaunorubicin and analogs
ZA814722B (en) *	1980-07-18	1982-07-28	Hoffmann La Roche	Novel anthracycline glycosides
GB8317037D0 (en) *	1983-06-23	1983-07-27	Erba Farmitalia	6-deoxyanthracyclines
US5138042A (en) *	1981-05-28	1992-08-11	Farmitalia Carlo Erba S.P.A.	6-deoxyanthracyclines
IT1210476B (it) *	1981-05-28	1989-09-14	Erba Farmitalia	Antracicline.
US4563444A (en) *	1982-05-26	1986-01-07	Farmitalia Carlo Erba S.P.A.	Anthracycline glycosides, use and compositions containing same
US4604381A (en) *	1982-07-16	1986-08-05	Farmitalia Carlo Erba S.P.A.	4-demethoxy-13-dihydrodaunorubicin and use thereof
US4562177A (en) *	1982-08-17	1985-12-31	The Ohio State University Research Foundation	3'-Amino-2' halo-anthracycline antibiotics
US4564674A (en) *	1983-10-31	1986-01-14	Sagami Chemical Research Center	Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) *	1983-11-25	1985-01-29	G. D. Searle & Co.	Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4537882A (en) *	1984-05-10	1985-08-27	Ohio State University	4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
US4697005A (en) *	1985-03-20	1987-09-29	Ohio State University Research Foundation	1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
US5124317A (en) *	1985-08-02	1992-06-23	Farmitalia Carlo Erba S.P.A.	Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
JPS63191263U (ru) *	1987-05-29	1988-12-09
GB2212154B (en) *	1987-11-10	1991-03-27	Erba Carlo Spa	New 4-demethoxy anthracycline derivatives
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) *	1988-07-29	1988-09-01	Erba Carlo Spa	Novel 4-substituted anthracyclinones & process for their preparation
CA2131372C (en) *	1992-03-02	1998-07-14	Kevin Koch	Sugar derivatives of macrolides
WO2004033666A2 (en) *	2002-10-11	2004-04-22	Board Of Regents, The University Of Texas System	Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
AU2006207321B2 (en)	2005-01-21	2012-09-06	Astex Therapeutics Limited	Pharmaceutical compounds
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044045A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
CL2009002208A1 (es) *	2008-12-23	2010-10-29	Gilead Pharmasset Llc	Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
KR20110104074A (ko) *	2008-12-23	2011-09-21	파마셋 인코포레이티드	퓨린 뉴클레오시드의 합성
SG172359A1 (en)	2008-12-23	2011-07-28	Pharmasset Inc	Nucleoside phosphoramidates
MX357972B (es)	2009-11-13	2018-08-01	Amgen Inc	Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
KR101715981B1 (ko)	2010-03-31	2017-03-13	길리애드 파마셋 엘엘씨	뉴클레오사이드 포스포르아미데이트
CA2815154A1 (en)	2010-08-06	2012-02-09	U3 Pharma Gmbh	Use of her3 binding agents in prostate treatment
DE102011113652A1 (de)	2011-09-19	2013-03-21	Heraeus Precious Metals Gmbh & Co. Kg	Kristallisierung von Idarubicinhydrochlorid
WO2013051994A1 (en)	2011-10-03	2013-04-11	Moreinx Ab	Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
US9907846B2 (en)	2013-04-01	2018-03-06	Mx Adjuvac Ab	Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
EP3669890A1 (en)	2018-12-18	2020-06-24	Croda International PLC	Filamentous nanoparticles having vaccine adjuvant effect

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3427300A (en) *	1965-11-12	1969-02-11	Merck & Co Inc	Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
US3803124A (en) *	1968-04-12	1974-04-09	Farmaceutici It Soc	Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) *	1968-05-14	1972-08-22	Farmaceutici Italia	Dihydrodaunomycin antibiotic and derivatives thereof

1974
- 1974-06-12 GB GB2608374A patent/GB1467383A/en not_active Expired
1975
- 1975-05-22 US US05/579,901 patent/US4046878A/en not_active Expired - Lifetime
- 1975-06-06 NL NLAANVRAGE7506745,A patent/NL173272C/xx not_active IP Right Cessation
- 1975-06-09 DE DE19752525633 patent/DE2525633A1/de active Granted
- 1975-06-09 AT AT437375A patent/AT337363B/de not_active IP Right Cessation
- 1975-06-09 DK DK256875A patent/DK147304C/da not_active IP Right Cessation
- 1975-06-09 DE DE1993175027 patent/DE19375027I2/de active Active
- 1975-06-09 FR FR7517881A patent/FR2274629A1/fr active Granted
- 1975-06-09 SE SE7506589A patent/SE423633B/xx not_active IP Right Cessation
- 1975-06-10 SU SU752141338A patent/SU645588A3/ru active
- 1975-06-10 JP JP50069250A patent/JPS5840557B2/ja not_active Expired
- 1975-06-10 ZA ZA00753722A patent/ZA753722B/xx unknown
- 1975-06-11 CH CH756375A patent/CH611317A5/xx not_active IP Right Cessation
- 1975-06-11 ES ES438431A patent/ES438431A1/es not_active Expired
- 1975-06-11 BE BE157205A patent/BE830090A/xx not_active IP Right Cessation
1982
- 1982-01-14 HK HK9/82A patent/HK982A/xx unknown
1988
- 1988-12-22 MY MYPI88001506A patent/MY103666A/en unknown
1993
- 1993-11-11 BG BG098211A patent/BG61059B2/bg unknown

Also Published As

Publication number	Publication date
FR2274629A1 (fr)	1976-01-09
DE2525633B2 (ru)	1979-03-01
SU645588A3 (ru)	1979-01-30
JPS5840557B2 (ja)	1983-09-06
NL7506745A (nl)	1975-12-16
BE830090A (fr)	1975-12-11
HK982A (en)	1982-01-22
ES438431A1 (es)	1977-02-01
DE19375027I2 (de)	2002-06-13
NL173272C (nl)	1984-01-02
SE423633B (sv)	1982-05-17
GB1467383A (en)	1977-03-16
DK147304B (da)	1984-06-12
ZA753722B (en)	1976-09-29
JPS518260A (ru)	1976-01-23
NL173272B (nl)	1983-08-01
SE7506589L (sv)	1975-12-15
US4046878A (en)	1977-09-06
DE2525633C3 (ru)	1979-10-18
CH611317A5 (ru)	1979-05-31
ATA437375A (de)	1976-10-15
DK147304C (da)	1984-12-17
AT337363B (de)	1977-06-27
DE2525633A1 (de)	1976-01-02
DK256875A (da)	1975-12-13
MY103666A (en)	1993-08-28
FR2274629B1 (ru)	1980-01-11
AU8197975A (en)	1976-12-16

Publication	Publication Date	Title
BG61059B2 (bg)	1996-09-30	Аналози на дономицина
CA1041488A (en)	1978-10-31	Process for the preparation of analogues of daunomycin
US4960790A (en)	1990-10-02	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
DK146626B (da)	1983-11-21	Analogifremgangsmaade til fremstilling af 4'-deoxydaunomycin
EP3505526B1 (en)	2024-05-15	Myricetin derivative and preparing method thereof, and application of same for treating colitis, preventing and treating colitis tumorigenesis, and treating colorectal cancer
JPS6169784A (ja)	1986-04-10	ペンタエリトリトール誘導体を配位子として有するシス―白金錯体およびそれらの製法
CN1950376A (zh)	2007-04-18	莪术醇衍生物、含该衍生物的组合物及所述衍生物的制药用途
US5091521A (en)	1992-02-25	Cis-platinum complexes, a process for the preparation thereof, and pharmaceuticals containing these compounds
DK146542B (da)	1983-10-31	Analogifremgangsmaade til fremstilling af daunosaminylanthracyclioner
US4031211A (en)	1977-06-21	Adriamycin esters, their preparation and use
JPH01308267A (ja)	1989-12-12	新規なアリステロマイシン／アデノシン誘導体類
US4188377A (en)	1980-02-12	Carminomycin derivatives, their preparation and use
CN107286220B (zh)	2020-10-23	1,2,4-三氮唑偶联的二氢杨梅素衍生物及其制备方法和应用
SU575031A3 (ru)	1977-09-30	Способ получени конденсированных трициклических производных имидазола или их солей
KR102640022B1 (ko)	2024-02-27	시클로부탄 디카르복실산 백금 착체, 그의 중간체, 그의 제조방법, 의약 조성물 및 사용
US4191755A (en)	1980-03-04	Novel daunomycin derivatives, their aglycones and the use thereof
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